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Research at St Andrews

Computational modelling and simulation of cancer growth and migration within a 3D heterogeneous tissue: the effects of fibre and vascular structure

Research output: Contribution to journalArticle

Open Access Status

  • Embargoed (until 17/12/20)

Author(s)

Cicely K. Macnamara, Alfonso Caiazzo, Ignacio Ramis-Conde, Mark Andrew Joseph Chaplain

School/Research organisations

Abstract

The term cancer covers a multitude of bodily diseases, broadly categorised by having cells which do not behave normally. Since cancer cells can arise from any type of cell in the body, cancers can grow in or around any tissue or organ making the disease highly complex. Our research is focused on understanding the specific mechanisms that occur in the tumour microenvironment via mathematical and computational modeling. We present a 3D individual-based model which allows one to simulate the behaviour of, and spatio-temporal interactions between, cells, extracellular matrix fibres and blood vessels. Each agent (a single cell, for example) is fully realised within the model and interactions are primarily governed by mechanical forces between elements. However, as well as the mechanical interactions we also consider chemical interactions, for example, by coupling the code to a finite element solver to model the diffusion of oxygen from blood vessels to cells. The current state of the art of the model allows us to simulate tumour growth around an arbitrary blood-vessel network or along the striations of fibrous tissue.
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Details

Original languageEnglish
Article number101067
JournalJournal of Computational Science
VolumeIn press
Early online date17 Dec 2019
DOIs
Publication statusE-pub ahead of print - 17 Dec 2019

    Research areas

  • Cancer modelling, Individual-based model, Cell-matrix interaction, Vasculature, Finite element method

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