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Context-dependent associations between heterozygosity and immune variation in a wild carnivore Evolutionary ecology and behaviour

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Context-dependent associations between heterozygosity and immune variation in a wild carnivore Evolutionary ecology and behaviour. / Brock, P.M.; Goodman, S.J.; Hall, Ailsa Jane; Cruz, M.; Acevedo-Whitehouse, K.

In: BMC Evolutionary Biology, Vol. 15, No. 1, 04.11.2015.

Research output: Contribution to journalArticle

Harvard

Brock, PM, Goodman, SJ, Hall, AJ, Cruz, M & Acevedo-Whitehouse, K 2015, 'Context-dependent associations between heterozygosity and immune variation in a wild carnivore Evolutionary ecology and behaviour' BMC Evolutionary Biology, vol. 15, no. 1. https://doi.org/10.1186/s12862-015-0519-6

APA

Brock, P. M., Goodman, S. J., Hall, A. J., Cruz, M., & Acevedo-Whitehouse, K. (2015). Context-dependent associations between heterozygosity and immune variation in a wild carnivore Evolutionary ecology and behaviour. BMC Evolutionary Biology, 15(1). https://doi.org/10.1186/s12862-015-0519-6

Vancouver

Brock PM, Goodman SJ, Hall AJ, Cruz M, Acevedo-Whitehouse K. Context-dependent associations between heterozygosity and immune variation in a wild carnivore Evolutionary ecology and behaviour. BMC Evolutionary Biology. 2015 Nov 4;15(1). https://doi.org/10.1186/s12862-015-0519-6

Author

Brock, P.M. ; Goodman, S.J. ; Hall, Ailsa Jane ; Cruz, M. ; Acevedo-Whitehouse, K. / Context-dependent associations between heterozygosity and immune variation in a wild carnivore Evolutionary ecology and behaviour. In: BMC Evolutionary Biology. 2015 ; Vol. 15, No. 1.

Bibtex - Download

@article{d943fe374eb74e9ca361f8a674af2e59,
title = "Context-dependent associations between heterozygosity and immune variation in a wild carnivore Evolutionary ecology and behaviour",
abstract = "Background: A multitude of correlations between heterozygosity and fitness proxies associated with disease have been reported from wild populations, but the genetic basis of these associations is unresolved. We used a longitudinal dataset on wild Galapagos sea lions (Zalophus wollebaeki) to develop a relatively new perspective on this problem, by testing for associations between heterozygosity and immune variation across age classes and between ecological contexts. Results: Homozygosity by locus was negatively correlated with serum immunoglobulin G production in pups (0-3 months of age), suggesting that reduced genetic diversity has a detrimental influence on the early development of immune defence in the Galapagos sea lion. In addition, homozygosity by locus was positively correlated with total circulating leukocyte concentration in juveniles (6-24 months of age), but only in a colony subject to the anthropogenic environmental impacts of development, pollution and introduced species, which suggests that reduced genetic diversity influences mature immune system activity in circumstances of high antigen exposure. Conclusions: These findings demonstrate the environmental context-dependency of the phenotypic expression of immune variation, which is implicit in the theory of ecoimmunology, but which has been rarely demonstrated in the wild. They also indicate that heterozygosity may be linked to the maintenance of heterogeneity in mammalian immune system development and response to infection, adding to the body of evidence on the nature of the mechanistic link between heterozygosity and fitness.",
author = "P.M. Brock and S.J. Goodman and Hall, {Ailsa Jane} and M. Cruz and K. Acevedo-Whitehouse",
year = "2015",
month = "11",
day = "4",
doi = "10.1186/s12862-015-0519-6",
language = "English",
volume = "15",
journal = "BMC Evolutionary Biology",
issn = "1471-2148",
publisher = "BioMed Central",
number = "1",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Context-dependent associations between heterozygosity and immune variation in a wild carnivore Evolutionary ecology and behaviour

AU - Brock, P.M.

AU - Goodman, S.J.

AU - Hall, Ailsa Jane

AU - Cruz, M.

AU - Acevedo-Whitehouse, K.

PY - 2015/11/4

Y1 - 2015/11/4

N2 - Background: A multitude of correlations between heterozygosity and fitness proxies associated with disease have been reported from wild populations, but the genetic basis of these associations is unresolved. We used a longitudinal dataset on wild Galapagos sea lions (Zalophus wollebaeki) to develop a relatively new perspective on this problem, by testing for associations between heterozygosity and immune variation across age classes and between ecological contexts. Results: Homozygosity by locus was negatively correlated with serum immunoglobulin G production in pups (0-3 months of age), suggesting that reduced genetic diversity has a detrimental influence on the early development of immune defence in the Galapagos sea lion. In addition, homozygosity by locus was positively correlated with total circulating leukocyte concentration in juveniles (6-24 months of age), but only in a colony subject to the anthropogenic environmental impacts of development, pollution and introduced species, which suggests that reduced genetic diversity influences mature immune system activity in circumstances of high antigen exposure. Conclusions: These findings demonstrate the environmental context-dependency of the phenotypic expression of immune variation, which is implicit in the theory of ecoimmunology, but which has been rarely demonstrated in the wild. They also indicate that heterozygosity may be linked to the maintenance of heterogeneity in mammalian immune system development and response to infection, adding to the body of evidence on the nature of the mechanistic link between heterozygosity and fitness.

AB - Background: A multitude of correlations between heterozygosity and fitness proxies associated with disease have been reported from wild populations, but the genetic basis of these associations is unresolved. We used a longitudinal dataset on wild Galapagos sea lions (Zalophus wollebaeki) to develop a relatively new perspective on this problem, by testing for associations between heterozygosity and immune variation across age classes and between ecological contexts. Results: Homozygosity by locus was negatively correlated with serum immunoglobulin G production in pups (0-3 months of age), suggesting that reduced genetic diversity has a detrimental influence on the early development of immune defence in the Galapagos sea lion. In addition, homozygosity by locus was positively correlated with total circulating leukocyte concentration in juveniles (6-24 months of age), but only in a colony subject to the anthropogenic environmental impacts of development, pollution and introduced species, which suggests that reduced genetic diversity influences mature immune system activity in circumstances of high antigen exposure. Conclusions: These findings demonstrate the environmental context-dependency of the phenotypic expression of immune variation, which is implicit in the theory of ecoimmunology, but which has been rarely demonstrated in the wild. They also indicate that heterozygosity may be linked to the maintenance of heterogeneity in mammalian immune system development and response to infection, adding to the body of evidence on the nature of the mechanistic link between heterozygosity and fitness.

UR - http://www.biomedcentral.com/1471-2148/15/242/additional

U2 - 10.1186/s12862-015-0519-6

DO - 10.1186/s12862-015-0519-6

M3 - Article

VL - 15

JO - BMC Evolutionary Biology

T2 - BMC Evolutionary Biology

JF - BMC Evolutionary Biology

SN - 1471-2148

IS - 1

ER -

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ID: 234010997