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Cortisol regulates eel (Anguilla anguilla) aquaporin 3 (AQP3) mRNA expression levels in gill

Research output: Contribution to journalArticle

Author(s)

C. P. Cutler, C. Phillips, N. Hazon, G. Cramb

School/Research organisations

Abstract

Previous studies in eel (Anguilla anguilla) gill have shown that the expression of the aquaporin 3 (AQP3) water and small solute channel is dramatically decreased (mRNA abundance decreased by up to 97%) when these euryhaline fish are acclimated from freshwater (FW) to seawater (SW). However, AQP3 mRNA expression levels in the intestine following SW-acclimation do not change. The SW-acclimating corticosteroid hormone, cortisol has previously been shown to regulate the expression of aquaporins (particularly AQP1) in eel osmoregulatory tissues in a tissue-specific and isoform-specific fashion. AQP1 is up-regulated in intestine and oesophagus, but down-regulated in kidney, following SW-acclimation in these fish. This study extends knowledge of the regulation of aquaporin expression by cortisol in the eel and shows that elevated levels of this hormone down-regulate AQP3 mRNA expression in the gill in a similar manner to SW-acclimation. However, the smaller magnitude of the changes in branchial AQP3 expression induced by cortisol-infusion (around a 60% decrease), in comparison to those occurring following SW-acclimation, suggest that other factors must also contribute to AQP3 down-regulation. In a similar fashion to the regulation of AQP1 by cortisol, changes in AQP3 expression following hormone infusion appear to be tissue-specific, as little effect was seen on the level of AQP3 expression in the intestine. Again the apparent lack of change in intestinal AQP3 expression following cortisol-infusion mimicked the invariant level of intestinal AQP3 mRNA abundance following SW-acclimation. (c) 2007 Elsevier Inc. All rights reserved.

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Details

Original languageEnglish
Pages (from-to)310-313
Number of pages4
JournalGeneral and Comparative Endocrinology
Volume152
DOIs
StatePublished - Jun 2007

    Research areas

  • aquaporin 3, cortisol, gill, intestine, mRNA expression, EUROPEAN EEL, WATER CHANNELS, SEAWATER ACCLIMATION, NA,K-ATPASE, CHLORIDE, CELLS, FISH, RAT

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