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COVID-19 in Pregnancy in Scotland (COPS): protocol for an observational study using linked Scottish national data

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COVID-19 in Pregnancy in Scotland (COPS) : protocol for an observational study using linked Scottish national data. / Stock, Sarah; McAllister, David; Vasileiou, Eleftheria; Simpson, Colin R; Stagg, Helen R; Agrawal, Utkarsh; McCowan, Colin; Hopkins, Leanne; Donaghy, Jack; Ritchie, Lewis; Robertson, Chris; Sheikh, Aziz; Wood, Rachael.

In: BMJ Open, Vol. 10, No. 11, e042813, 26.11.2020.

Research output: Contribution to journalArticlepeer-review

Harvard

Stock, S, McAllister, D, Vasileiou, E, Simpson, CR, Stagg, HR, Agrawal, U, McCowan, C, Hopkins, L, Donaghy, J, Ritchie, L, Robertson, C, Sheikh, A & Wood, R 2020, 'COVID-19 in Pregnancy in Scotland (COPS): protocol for an observational study using linked Scottish national data', BMJ Open, vol. 10, no. 11, e042813. https://doi.org/10.1136/bmjopen-2020-042813

APA

Stock, S., McAllister, D., Vasileiou, E., Simpson, C. R., Stagg, H. R., Agrawal, U., McCowan, C., Hopkins, L., Donaghy, J., Ritchie, L., Robertson, C., Sheikh, A., & Wood, R. (2020). COVID-19 in Pregnancy in Scotland (COPS): protocol for an observational study using linked Scottish national data. BMJ Open, 10(11), [e042813]. https://doi.org/10.1136/bmjopen-2020-042813

Vancouver

Stock S, McAllister D, Vasileiou E, Simpson CR, Stagg HR, Agrawal U et al. COVID-19 in Pregnancy in Scotland (COPS): protocol for an observational study using linked Scottish national data. BMJ Open. 2020 Nov 26;10(11). e042813. https://doi.org/10.1136/bmjopen-2020-042813

Author

Stock, Sarah ; McAllister, David ; Vasileiou, Eleftheria ; Simpson, Colin R ; Stagg, Helen R ; Agrawal, Utkarsh ; McCowan, Colin ; Hopkins, Leanne ; Donaghy, Jack ; Ritchie, Lewis ; Robertson, Chris ; Sheikh, Aziz ; Wood, Rachael. / COVID-19 in Pregnancy in Scotland (COPS) : protocol for an observational study using linked Scottish national data. In: BMJ Open. 2020 ; Vol. 10, No. 11.

Bibtex - Download

@article{3ec5b37b399548b595feb57509adaf5e,
title = "COVID-19 in Pregnancy in Scotland (COPS): protocol for an observational study using linked Scottish national data",
abstract = "Introduction The effects of SARS-CoV-2 in pregnancy are not fully delineated. We will describe the incidence of COVID-19 in pregnancy at population level in Scotland, in a prospective cohort study using linked data. We will determine associations between COVID-19 and adverse pregnancy, neonatal and maternal outcomes and the proportion of confirmed cases of SARS-CoV-2 infection in neonates associated with maternal COVID-19.Methods and analysis Prospective cohort study using national linked data sets. We will include all women in Scotland, UK, who were pregnant on or became pregnant after, 1 March 2020 (the date of the first confirmed case of SARS-CoV-2 infection in Scotland) and all births in Scotland from 1 March 2020 onwards. Individual-level data will be extracted from data sets containing details of all livebirths, stillbirth, terminations of pregnancy and miscarriages and ectopic pregnancies treated in hospital or attending general practice. Records will be linked within the Early Pandemic Evaluation and Enhanced Surveillance of COVID-19 (EAVE II) platform, which includes primary care records, virology and serology results and details of COVID-19 Community Hubs and Assessment Centre contacts and deaths. We will perform analyses using definitions for confirmed, probable and possible COVID-19 and report serology results (where available). Outcomes will include congenital anomaly, miscarriage, stillbirth, termination of pregnancy, preterm birth, neonatal infection, severe maternal disease and maternal deaths. We will perform descriptive analyses and appropriate modelling, adjusting for demographic and pregnancy characteristics and the presence of comorbidities. The cohort will provide a platform for future studies of the effectiveness and safety of therapeutic interventions and immunisations for COVID-19 and their effects on childhood and developmental outcomes.Ethics and dissemination COVID-19 in Pregnancy in Scotland is a substudy of EAVE II(, which has approval from the National Research Ethics Service Committee. Findings will be reported to Scottish Government, Public Health Scotland and published in peer-reviewed journals.",
author = "Sarah Stock and David McAllister and Eleftheria Vasileiou and Simpson, {Colin R} and Stagg, {Helen R} and Utkarsh Agrawal and Colin McCowan and Leanne Hopkins and Jack Donaghy and Lewis Ritchie and Chris Robertson and Aziz Sheikh and Rachael Wood",
note = "Funding: EAVE II funded by the Medical Research Council (MR/R008345/1) with the support of BREATHE - The Health Data Research Hub for Respiratory Health [MC_PC_19004], which is funded through the UK Research and Innovation Industrial Strategy Challenge Fund and delivered through Health Data Research UK. Additional support has been provided through the Scottish Government DG Health and Social Care. COPS receive additional funding from Tommy{\textquoteright}s charity (1060508; SC039280). SJS is supported by Wellcome Trust (209560/Z/17/Z).",
year = "2020",
month = nov,
day = "26",
doi = "10.1136/bmjopen-2020-042813",
language = "English",
volume = "10",
journal = "BMJ Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group Ltd",
number = "11",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - COVID-19 in Pregnancy in Scotland (COPS)

T2 - protocol for an observational study using linked Scottish national data

AU - Stock, Sarah

AU - McAllister, David

AU - Vasileiou, Eleftheria

AU - Simpson, Colin R

AU - Stagg, Helen R

AU - Agrawal, Utkarsh

AU - McCowan, Colin

AU - Hopkins, Leanne

AU - Donaghy, Jack

AU - Ritchie, Lewis

AU - Robertson, Chris

AU - Sheikh, Aziz

AU - Wood, Rachael

N1 - Funding: EAVE II funded by the Medical Research Council (MR/R008345/1) with the support of BREATHE - The Health Data Research Hub for Respiratory Health [MC_PC_19004], which is funded through the UK Research and Innovation Industrial Strategy Challenge Fund and delivered through Health Data Research UK. Additional support has been provided through the Scottish Government DG Health and Social Care. COPS receive additional funding from Tommy’s charity (1060508; SC039280). SJS is supported by Wellcome Trust (209560/Z/17/Z).

PY - 2020/11/26

Y1 - 2020/11/26

N2 - Introduction The effects of SARS-CoV-2 in pregnancy are not fully delineated. We will describe the incidence of COVID-19 in pregnancy at population level in Scotland, in a prospective cohort study using linked data. We will determine associations between COVID-19 and adverse pregnancy, neonatal and maternal outcomes and the proportion of confirmed cases of SARS-CoV-2 infection in neonates associated with maternal COVID-19.Methods and analysis Prospective cohort study using national linked data sets. We will include all women in Scotland, UK, who were pregnant on or became pregnant after, 1 March 2020 (the date of the first confirmed case of SARS-CoV-2 infection in Scotland) and all births in Scotland from 1 March 2020 onwards. Individual-level data will be extracted from data sets containing details of all livebirths, stillbirth, terminations of pregnancy and miscarriages and ectopic pregnancies treated in hospital or attending general practice. Records will be linked within the Early Pandemic Evaluation and Enhanced Surveillance of COVID-19 (EAVE II) platform, which includes primary care records, virology and serology results and details of COVID-19 Community Hubs and Assessment Centre contacts and deaths. We will perform analyses using definitions for confirmed, probable and possible COVID-19 and report serology results (where available). Outcomes will include congenital anomaly, miscarriage, stillbirth, termination of pregnancy, preterm birth, neonatal infection, severe maternal disease and maternal deaths. We will perform descriptive analyses and appropriate modelling, adjusting for demographic and pregnancy characteristics and the presence of comorbidities. The cohort will provide a platform for future studies of the effectiveness and safety of therapeutic interventions and immunisations for COVID-19 and their effects on childhood and developmental outcomes.Ethics and dissemination COVID-19 in Pregnancy in Scotland is a substudy of EAVE II(, which has approval from the National Research Ethics Service Committee. Findings will be reported to Scottish Government, Public Health Scotland and published in peer-reviewed journals.

AB - Introduction The effects of SARS-CoV-2 in pregnancy are not fully delineated. We will describe the incidence of COVID-19 in pregnancy at population level in Scotland, in a prospective cohort study using linked data. We will determine associations between COVID-19 and adverse pregnancy, neonatal and maternal outcomes and the proportion of confirmed cases of SARS-CoV-2 infection in neonates associated with maternal COVID-19.Methods and analysis Prospective cohort study using national linked data sets. We will include all women in Scotland, UK, who were pregnant on or became pregnant after, 1 March 2020 (the date of the first confirmed case of SARS-CoV-2 infection in Scotland) and all births in Scotland from 1 March 2020 onwards. Individual-level data will be extracted from data sets containing details of all livebirths, stillbirth, terminations of pregnancy and miscarriages and ectopic pregnancies treated in hospital or attending general practice. Records will be linked within the Early Pandemic Evaluation and Enhanced Surveillance of COVID-19 (EAVE II) platform, which includes primary care records, virology and serology results and details of COVID-19 Community Hubs and Assessment Centre contacts and deaths. We will perform analyses using definitions for confirmed, probable and possible COVID-19 and report serology results (where available). Outcomes will include congenital anomaly, miscarriage, stillbirth, termination of pregnancy, preterm birth, neonatal infection, severe maternal disease and maternal deaths. We will perform descriptive analyses and appropriate modelling, adjusting for demographic and pregnancy characteristics and the presence of comorbidities. The cohort will provide a platform for future studies of the effectiveness and safety of therapeutic interventions and immunisations for COVID-19 and their effects on childhood and developmental outcomes.Ethics and dissemination COVID-19 in Pregnancy in Scotland is a substudy of EAVE II(, which has approval from the National Research Ethics Service Committee. Findings will be reported to Scottish Government, Public Health Scotland and published in peer-reviewed journals.

U2 - 10.1136/bmjopen-2020-042813

DO - 10.1136/bmjopen-2020-042813

M3 - Article

VL - 10

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 11

M1 - e042813

ER -

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