Skip to content

Research at St Andrews

Crosstalk between zinc and fatty acids in plasma

Research output: Contribution to journalReview article

Abstract

In mammalian blood plasma, serum albumin acts as a transport protein for free fatty acids, other lipids and hydrophobic molecules including neurodegenerative peptides, and essential metal ions such as zinc to allow their systemic distribution. Importantly, binding of these chemically extremely diverse entities is not independent, but linked allosterically. One particularly intriguing allosteric link exists between free fatty acid and zinc binding. Albumin thus mediates crosstalk between energy status/metabolism and organismal zinc handling. In recognition of the fact that even small changes in extracellular zinc concentration and speciation modulate the function of many cell types, the albumin-mediated impact of free fatty acid concentration on zinc distribution may be significant for both normal physiological processes including energy metabolism, insulin activity, heparin neutralisation, blood coagulation, and zinc signalling, and a range of disease states, including metabolic syndrome, cardiovascular disease, myocardial ischemia, diabetes, and thrombosis.
Close

Details

Original languageEnglish
Pages (from-to)532-542
Number of pages11
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume1864
Issue number4
Early online date25 Sep 2018
DOIs
Publication statusPublished - Apr 2019

    Research areas

  • Zinc, Non-esterified fatty acids, Plasma, Serum, Albumin

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. On the origin of proteins in human drusen: the meet, greet and stick hypothesis

    Bergen, A. A., Arya, S., Koster, C., Pilgrim, M. G., Wiatrek-Moumoulidis, D., van der Spek, P., Hauck, S. M., Boon, C. J. F., Emri, E., Stewart, A. J. & Lengyel, I., May 2019, In : Progress in Retinal and Eye Research. 70, p. 55-84 30 p.

    Research output: Contribution to journalArticle

  2. Ischemia-modified albumin: crosstalk between fatty acid and cobalt binding

    Coverdale, J. P. C., Katundu, K. G. H., Sobczak, A. I. S., Arya, S., Blindauer, C. A. & Stewart, A. J., Aug 2018, In : Prostaglandins, Leukotrienes and Essential Fatty Acids. 135, p. 147-157 11 p.

    Research output: Contribution to journalReview article

  3. Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration

    Arya, S., Emri, E., Synowsky, S. A., Shirran, S. L., Barzegar-Befroei, N., Peto, T., Botting, C. H., Lengyel, I. & Stewart, A. J., Jul 2018, In : Experimental Eye Research. 172, p. 21-29 9 p.

    Research output: Contribution to journalArticle

  4. A metalloproteomic analysis of interactions between plasma proteins and zinc: elevated fatty acid levels affect zinc distribution

    Coverdale, J. P. C., Barnett, J. P., Adamu, A. H., Griffiths, E. J., Stewart, A. J. & Blindauer, C. A., 12 Sep 2019, (Accepted/In press) In : Metallomics.

    Research output: Contribution to journalArticle

Related by journal

  1. Natural ligand binding and transfer from liver fatty acid binding protein (LFABP) to membranes

    De Geronimo, E., Hagan, R. M., Wilton, D. C. & Corsico, B., Sep 2010, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1801, 9, p. 1082-1089 8 p.

    Research output: Contribution to journalArticle

ID: 255949100