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Crosstalk between zinc and fatty acids in plasma

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Crosstalk between zinc and fatty acids in plasma. / Coverdale, James P. C.; Khazaipoul, Siavash; Arya, Swati; Stewart, Alan J.; Blindauer, Claudia A.

In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Vol. 1864, No. 4, 04.2019, p. 532-542.

Research output: Contribution to journalReview article

Harvard

Coverdale, JPC, Khazaipoul, S, Arya, S, Stewart, AJ & Blindauer, CA 2019, 'Crosstalk between zinc and fatty acids in plasma', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, vol. 1864, no. 4, pp. 532-542. https://doi.org/10.1016/j.bbalip.2018.09.007

APA

Coverdale, J. P. C., Khazaipoul, S., Arya, S., Stewart, A. J., & Blindauer, C. A. (2019). Crosstalk between zinc and fatty acids in plasma. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1864(4), 532-542. https://doi.org/10.1016/j.bbalip.2018.09.007

Vancouver

Coverdale JPC, Khazaipoul S, Arya S, Stewart AJ, Blindauer CA. Crosstalk between zinc and fatty acids in plasma. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2019 Apr;1864(4):532-542. https://doi.org/10.1016/j.bbalip.2018.09.007

Author

Coverdale, James P. C. ; Khazaipoul, Siavash ; Arya, Swati ; Stewart, Alan J. ; Blindauer, Claudia A. / Crosstalk between zinc and fatty acids in plasma. In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2019 ; Vol. 1864, No. 4. pp. 532-542.

Bibtex - Download

@article{b248a1efea7b414fbb9d2815e82b2185,
title = "Crosstalk between zinc and fatty acids in plasma",
abstract = "In mammalian blood plasma, serum albumin acts as a transport protein for free fatty acids, other lipids and hydrophobic molecules including neurodegenerative peptides, and essential metal ions such as zinc to allow their systemic distribution. Importantly, binding of these chemically extremely diverse entities is not independent, but linked allosterically. One particularly intriguing allosteric link exists between free fatty acid and zinc binding. Albumin thus mediates crosstalk between energy status/metabolism and organismal zinc handling. In recognition of the fact that even small changes in extracellular zinc concentration and speciation modulate the function of many cell types, the albumin-mediated impact of free fatty acid concentration on zinc distribution may be significant for both normal physiological processes including energy metabolism, insulin activity, heparin neutralisation, blood coagulation, and zinc signalling, and a range of disease states, including metabolic syndrome, cardiovascular disease, myocardial ischemia, diabetes, and thrombosis.",
keywords = "Zinc, Non-esterified fatty acids, Plasma, Serum, Albumin",
author = "Coverdale, {James P. C.} and Siavash Khazaipoul and Swati Arya and Stewart, {Alan J.} and Blindauer, {Claudia A}",
note = "This work was supported by the Leverhulme Trust (grant ref. RPG-2017-214), BBSRC (grant ref. BB/J006467/1) and the British Heart Foundation (grant refs. PG/15/9/31270 and FS/15/42/31556).",
year = "2019",
month = "4",
doi = "10.1016/j.bbalip.2018.09.007",
language = "English",
volume = "1864",
pages = "532--542",
journal = "Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids",
issn = "1388-1981",
publisher = "Elsevier",
number = "4",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Crosstalk between zinc and fatty acids in plasma

AU - Coverdale, James P. C.

AU - Khazaipoul, Siavash

AU - Arya, Swati

AU - Stewart, Alan J.

AU - Blindauer, Claudia A

N1 - This work was supported by the Leverhulme Trust (grant ref. RPG-2017-214), BBSRC (grant ref. BB/J006467/1) and the British Heart Foundation (grant refs. PG/15/9/31270 and FS/15/42/31556).

PY - 2019/4

Y1 - 2019/4

N2 - In mammalian blood plasma, serum albumin acts as a transport protein for free fatty acids, other lipids and hydrophobic molecules including neurodegenerative peptides, and essential metal ions such as zinc to allow their systemic distribution. Importantly, binding of these chemically extremely diverse entities is not independent, but linked allosterically. One particularly intriguing allosteric link exists between free fatty acid and zinc binding. Albumin thus mediates crosstalk between energy status/metabolism and organismal zinc handling. In recognition of the fact that even small changes in extracellular zinc concentration and speciation modulate the function of many cell types, the albumin-mediated impact of free fatty acid concentration on zinc distribution may be significant for both normal physiological processes including energy metabolism, insulin activity, heparin neutralisation, blood coagulation, and zinc signalling, and a range of disease states, including metabolic syndrome, cardiovascular disease, myocardial ischemia, diabetes, and thrombosis.

AB - In mammalian blood plasma, serum albumin acts as a transport protein for free fatty acids, other lipids and hydrophobic molecules including neurodegenerative peptides, and essential metal ions such as zinc to allow their systemic distribution. Importantly, binding of these chemically extremely diverse entities is not independent, but linked allosterically. One particularly intriguing allosteric link exists between free fatty acid and zinc binding. Albumin thus mediates crosstalk between energy status/metabolism and organismal zinc handling. In recognition of the fact that even small changes in extracellular zinc concentration and speciation modulate the function of many cell types, the albumin-mediated impact of free fatty acid concentration on zinc distribution may be significant for both normal physiological processes including energy metabolism, insulin activity, heparin neutralisation, blood coagulation, and zinc signalling, and a range of disease states, including metabolic syndrome, cardiovascular disease, myocardial ischemia, diabetes, and thrombosis.

KW - Zinc

KW - Non-esterified fatty acids

KW - Plasma

KW - Serum

KW - Albumin

U2 - 10.1016/j.bbalip.2018.09.007

DO - 10.1016/j.bbalip.2018.09.007

M3 - Review article

VL - 1864

SP - 532

EP - 542

JO - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

JF - Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

SN - 1388-1981

IS - 4

ER -

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