Skip to content

Research at St Andrews

Cyclic Peptides: From Bioorganic Synthesis to Applications: The Biosynthesis of Cyclic Peptides – RiPPs – an Overview

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cyclic peptides are increasingly employed as chemical tools in biology and drug discovery. They have gained a lot of interest as alternative sources of new drugs to traditional small molecules.
This book introduces cyclic peptides and provides a thorough overview of biosynthetic and fully synthetic approaches to their preparation. Following an introduction to cyclic peptides, biosynthetic and traditional chemical routes to cyclic peptides are reviewed. Due to their size, their synthesis is not trivial. Recent advances in the incorporation of novel structural units are presented in addition to how synthesis and biological methods can be combined. The chemical analysis of this molecular class is also discussed. Furthermore, chapters detail the progression of cyclic peptides as tools in biology and as potential drugs, providing a future vision of their importance.
In total, this book provides the reader with a comprehensive view of the state-of-the-art of cyclic peptides, from construction to possible clinical utility. This book will be an essential resource for students, researchers and scientists within industry in medicinal, bioorganic, natural product and analytical chemistry fields.
Close

Details

Original languageEnglish
Title of host publicationCyclic Peptides: From Bioorganic Synthesis to Applications
Publication statusPublished - 1 Dec 2017

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Insights into the mechanism of the cyanobactin heterocyclase enzyme

    Ge, Y., Czekster, C. M., Miller, O. K., Botting, C. H., Schwarz-Linek, U. & Naismith, J. H., 23 Apr 2019, In : Biochemistry. 58, 16, p. 2125-2132 8 p.

    Research output: Contribution to journalArticle

  2. Allosteric activation shifts the rate-limiting step in a short-form ATP phosphoribosyltransferase

    Fisher, G., Thomson, C. M., Stroek, R., Czekster, C. M., Hirschi, J. S. & da Silva, R. G., 24 Jul 2018, In : Biochemistry. 57, 29, p. 4357-4367

    Research output: Contribution to journalArticle

  3. Characterization of the fast and promiscuous macrocyclase from plant PCY1 enables the use of simple substrates

    Ludewig, H., Czekster, C. M., Oueis, E., Munday, E. S., Arshad, M., Synowsky, S. A., Bent, A. F. & Naismith, J. H., 16 Mar 2018, In : ACS Chemical Biology. 13, 3, p. 801–811

    Research output: Contribution to journalArticle

  4. Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates

    Melo Czekster, C., Ludewig, H., McMahon, S. A. & Naismith, J. H., 19 Oct 2017, In : Nature Communications. 8, 1045.

    Research output: Contribution to journalArticle

  5. The rhizoferrin biosynthetic gene in the fungal pathogen Rhizopus delemar is a novel member of the NIS gene family

    Carroll, C. S., Grieve, C. L., Murugathasan, I., Bennet, A. J., Melo Czekster, C., Lui, H., Naismith, J. & Moore, M. M., Aug 2017, In : International Journal of Biochemistry and Cell Biology. 89, p. 136-146 11 p.

    Research output: Contribution to journalArticle

ID: 251446915

Top