Skip to content

Research at St Andrews

Deformation-compensated averaging for clutter reduction in epiphotoacoustic imaging in vivo

Research output: Contribution to journalArticle

Author(s)

Michael Jaeger, David Harris-Birtill, Andreas Gertsch, Elizabeth O'Flynn, Jeffrey Bamber

School/Research organisations

Abstract

Photoacoustic imaging, based on ultrasound detected after laser irradiation, is an extension to diagnostic ultrasound for imaging the vasculature, blood oxygenation and the uptake of optical contrast media with promise for cancer diagnosis. For versatile scanning, the irradiation optics is preferably combined with the acoustic probe in an epi-style arrangement avoiding acoustically dense tissue in the acoustic propagation path from tissue irradiation to acoustic detection. Unfortunately epiphotoacoustic imaging suffers from strong clutter, arising from optical absorption in tissue outside the image plane, and from acoustic backscattering. This limits the imaging depth for useful photoacoustic image contrast to typically less than one centimeter. Deformation-compensated averaging (DCA), which takes advantage of clutter decorrelation induced by palpating the tissue with the imaging probe, has previously been proposed for clutter reduction. We demonstrate for the first time that DCA results in reduced clutter in real-time freehand clinical epiphotoacoustic imaging. For this purpose, combined photoacoustic and pulse-echo imaging at 10-Hz frame rate was implemented on a commercial scanner, allowing for ultrasound-based motion tracking inherently coregistered with photoacoustic frames. Results from the forearm and the neck confirm that contrast is improved and imaging depth increased by DCA.

Close

Details

Original languageEnglish
Pages (from-to)066007
JournalJournal of Biomedical Optics
Volume17
Issue number6
DOIs
Publication statusPublished - Jun 2012

    Research areas

  • Acoustics, Algorithms, Contrast Media, Diagnostic Imaging, Humans, Hypoxia, Image Processing, Computer-Assisted, Light, Motion, Neoplasms, Optics and Photonics, Pattern Recognition, Automated, Photoacoustic Techniques, Photochemistry, Scattering, Radiation, Time Factors, Ultrasonography, Journal Article, Research Support, Non-U.S. Gov't

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Smart Homes for elderly to promote their health and wellbeing

    Pirzada, P., Wilde, A. G. & Harris-Birtill, D. C. C., 16 Sep 2019. 1 p.

    Research output: Contribution to conferencePoster

  2. A comparison of level set models in image segmentation

    Rahmat, R. & Harris-Birtill, D., 6 Dec 2018, In : IET Image Processing. 12, 12, p. 2212-2221 11 p.

    Research output: Contribution to journalArticle

  3. ‘Multiplicity embarrasses the eye’: The digital mapping of literary Edinburgh

    Loxley, J., Alex, B., Anderson, M., Hinrichs, U., Grover, C., Harris-Birtill, D., Thomson, T., Quigley, A. & Oberlander, J., 1 Jan 2018, The Routledge Companion to Spatial History. Taylor and Francis, p. 604-628 25 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  4. Gold nanorod reshaping in vitro and in vivo using a continuous wave laser

    Harris-Birtill, D., Singh, M., Zhou, Y., Ruenraroengsak, P., Gallina, M. E., Hanna, G. B., Cass, A. E. G., Porter, A. E., Bamber, J. & Elson, D. S., 18 Oct 2017, In : PLoS ONE. 12, 10, 21 p., e0185990.

    Research output: Contribution to journalArticle

  5. SpeCam: sensing surface color and material with the front-facing camera of mobile device

    Yeo, H. S., Lee, J., Bianchi, A., Harris-Birtill, D. & Quigley, A. J., 4 Sep 2017, Proceedings of the 19th International Conference on Human-Computer Interaction with Mobile Devices and Services. New York, NY: ACM, 9 p. 25

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

Related by journal

  1. Effect of beta-carotene supplementation on African skin

    Coetzee, V. & Perrett, D. I., 13 Feb 2014, In : Journal of Biomedical Optics. 19, 2

    Research output: Contribution to journalArticle

  2. Fluorescence suppression using wavelength modulated Raman spectroscopy in fiber-probe-based tissue analysis

    Balagopal, B., Ashok, P. C., Mazilu, M., Riches, A. C., Herrington, C. S. & Dholakia, K., 9 Jul 2012, In : Journal of Biomedical Optics. 17, 7, 6 p., 077006.

    Research output: Contribution to journalArticle

  3. Tissue surface as the reference arm in Fourier domain optical coherence tomography

    Krstajic, N., Brown, C. T. A., Dholakia, K. & Giardini, M. E., Jul 2012, In : Journal of Biomedical Optics. 17, 7, 6 p., 071305.

    Research output: Contribution to journalArticle

ID: 250005975

Top