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Degradation of the chemotherapy drug 5-fluorouracil on medical-grade silver surfaces

Research output: Contribution to journalArticlepeer-review

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Degradation of the chemotherapy drug 5-fluorouracil on medical-grade silver surfaces. / Risinggård, Helene Kjær; Cooil, Simon; Mazzola, Federico; Hu, Di; Kjærvik, Marit; Østli, Elise Ramleth; Patil, Nilesh; Preobrajenski, Alexei; Evans, D. Andrew; Breiby, Dag W.; Trinh, Thuat T.; Wells, Justin W.

In: Applied Surface Science, Vol. 435, 30.03.2018, p. 1213-1219.

Research output: Contribution to journalArticlepeer-review

Harvard

Risinggård, HK, Cooil, S, Mazzola, F, Hu, D, Kjærvik, M, Østli, ER, Patil, N, Preobrajenski, A, Evans, DA, Breiby, DW, Trinh, TT & Wells, JW 2018, 'Degradation of the chemotherapy drug 5-fluorouracil on medical-grade silver surfaces', Applied Surface Science, vol. 435, pp. 1213-1219. https://doi.org/10.1016/j.apsusc.2017.11.221

APA

Risinggård, H. K., Cooil, S., Mazzola, F., Hu, D., Kjærvik, M., Østli, E. R., Patil, N., Preobrajenski, A., Evans, D. A., Breiby, D. W., Trinh, T. T., & Wells, J. W. (2018). Degradation of the chemotherapy drug 5-fluorouracil on medical-grade silver surfaces. Applied Surface Science, 435, 1213-1219. https://doi.org/10.1016/j.apsusc.2017.11.221

Vancouver

Risinggård HK, Cooil S, Mazzola F, Hu D, Kjærvik M, Østli ER et al. Degradation of the chemotherapy drug 5-fluorouracil on medical-grade silver surfaces. Applied Surface Science. 2018 Mar 30;435:1213-1219. https://doi.org/10.1016/j.apsusc.2017.11.221

Author

Risinggård, Helene Kjær ; Cooil, Simon ; Mazzola, Federico ; Hu, Di ; Kjærvik, Marit ; Østli, Elise Ramleth ; Patil, Nilesh ; Preobrajenski, Alexei ; Evans, D. Andrew ; Breiby, Dag W. ; Trinh, Thuat T. ; Wells, Justin W. / Degradation of the chemotherapy drug 5-fluorouracil on medical-grade silver surfaces. In: Applied Surface Science. 2018 ; Vol. 435. pp. 1213-1219.

Bibtex - Download

@article{6041851e84db448db5a839840d69b8e0,
title = "Degradation of the chemotherapy drug 5-fluorouracil on medical-grade silver surfaces",
abstract = "The degradation of the chemotherapy drug 5-Fluorouracil by a non-pristine metal surfaces is studied. Using Density Functional Theory, X-ray Photoelectron Spectroscopy and X-ray Absorption Spectroscopy we show that the drug is entirely degraded by medical-grade silver surfaces, already at body temperature, and that all of the fluorine has left the molecule, presumably as HF. Remarkably, this degradation is even more severe than that reported previously for 5-Fluorouracil on a pristine monocrystalline silver surface (in which case 80% of the drug reacted at body temperature) Mazzola et al. (2015).We conclude that the observed reaction is due to a reaction pathway, driven by H to F attraction between molecules on the surface, which results in the direct formation of HF; a pathway which is favoured when competing pathways involving reactive Ag surface sites are made unavailable by environmental contamination. Our measurements indicate that realistically cleaned, non-pristine silver alloys, which are typically used in medical applications, can result in severe degradation of 5-Fluorouracil, with the release of HF – a finding which may have important implications for the handling of chemotherapy drugs.",
keywords = "Surface science, Chemotherapy, DFT, Photoemission, Fluorouracil, Silver",
author = "Risingg{\aa}rd, {Helene Kj{\ae}r} and Simon Cooil and Federico Mazzola and Di Hu and Marit Kj{\ae}rvik and {\O}stli, {Elise Ramleth} and Nilesh Patil and Alexei Preobrajenski and Evans, {D. Andrew} and Breiby, {Dag W.} and Trinh, {Thuat T.} and Wells, {Justin W.}",
note = "This research was supported in part with computational resources at NTNU provided by NOTUR (project nn9331k). NP and DWB acknowledge The Research Council of Norway for the financial support through M-ERA.NET project RADESOL under the European Union's seventh framework programme (FP/2007-2013), grant agreement no. 234648/O70.",
year = "2018",
month = mar,
day = "30",
doi = "10.1016/j.apsusc.2017.11.221",
language = "English",
volume = "435",
pages = "1213--1219",
journal = "Applied Surface Science",
issn = "0169-4332",
publisher = "Elsevier",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Degradation of the chemotherapy drug 5-fluorouracil on medical-grade silver surfaces

AU - Risinggård, Helene Kjær

AU - Cooil, Simon

AU - Mazzola, Federico

AU - Hu, Di

AU - Kjærvik, Marit

AU - Østli, Elise Ramleth

AU - Patil, Nilesh

AU - Preobrajenski, Alexei

AU - Evans, D. Andrew

AU - Breiby, Dag W.

AU - Trinh, Thuat T.

AU - Wells, Justin W.

N1 - This research was supported in part with computational resources at NTNU provided by NOTUR (project nn9331k). NP and DWB acknowledge The Research Council of Norway for the financial support through M-ERA.NET project RADESOL under the European Union's seventh framework programme (FP/2007-2013), grant agreement no. 234648/O70.

PY - 2018/3/30

Y1 - 2018/3/30

N2 - The degradation of the chemotherapy drug 5-Fluorouracil by a non-pristine metal surfaces is studied. Using Density Functional Theory, X-ray Photoelectron Spectroscopy and X-ray Absorption Spectroscopy we show that the drug is entirely degraded by medical-grade silver surfaces, already at body temperature, and that all of the fluorine has left the molecule, presumably as HF. Remarkably, this degradation is even more severe than that reported previously for 5-Fluorouracil on a pristine monocrystalline silver surface (in which case 80% of the drug reacted at body temperature) Mazzola et al. (2015).We conclude that the observed reaction is due to a reaction pathway, driven by H to F attraction between molecules on the surface, which results in the direct formation of HF; a pathway which is favoured when competing pathways involving reactive Ag surface sites are made unavailable by environmental contamination. Our measurements indicate that realistically cleaned, non-pristine silver alloys, which are typically used in medical applications, can result in severe degradation of 5-Fluorouracil, with the release of HF – a finding which may have important implications for the handling of chemotherapy drugs.

AB - The degradation of the chemotherapy drug 5-Fluorouracil by a non-pristine metal surfaces is studied. Using Density Functional Theory, X-ray Photoelectron Spectroscopy and X-ray Absorption Spectroscopy we show that the drug is entirely degraded by medical-grade silver surfaces, already at body temperature, and that all of the fluorine has left the molecule, presumably as HF. Remarkably, this degradation is even more severe than that reported previously for 5-Fluorouracil on a pristine monocrystalline silver surface (in which case 80% of the drug reacted at body temperature) Mazzola et al. (2015).We conclude that the observed reaction is due to a reaction pathway, driven by H to F attraction between molecules on the surface, which results in the direct formation of HF; a pathway which is favoured when competing pathways involving reactive Ag surface sites are made unavailable by environmental contamination. Our measurements indicate that realistically cleaned, non-pristine silver alloys, which are typically used in medical applications, can result in severe degradation of 5-Fluorouracil, with the release of HF – a finding which may have important implications for the handling of chemotherapy drugs.

KW - Surface science

KW - Chemotherapy

KW - DFT

KW - Photoemission

KW - Fluorouracil

KW - Silver

U2 - 10.1016/j.apsusc.2017.11.221

DO - 10.1016/j.apsusc.2017.11.221

M3 - Article

VL - 435

SP - 1213

EP - 1219

JO - Applied Surface Science

JF - Applied Surface Science

SN - 0169-4332

ER -

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