The A-site deficient perovskite: La_0.20Sr_0.25Ca_0.45TiO₃ (LSCT_A-) is a mixed ionic and electronic conductor (MIEC) which shows promising performance as a Solid Oxide Fuel Cell (SOFC) anode ‘backbone’ material, when impregnated with metallic and oxide-ion conducting electrocatalysts. Here, we present data on the complete ceramic processing and optimisation of the LSCT_A- ‘backbone’ microstructure, in order to improve current distribution throughout the anode. Through control of ink rheology, screen printing parameters and sintering protocol an advantageous LSCT_A- microstructural architecture was developed, exhibiting an ‘effective’ conductivity of 21 S cm^-1. Incorporation of this LSCT_A- anode microstructure into SOFC and impregnation with Ce_0.80Gd_0.20O_1.9 and either Ni, Ru, Rh, Pt or Pd resulted in promising initial performances during fuel cell testing in a fuel stream of 97% H₂:3% H2O. Area Specific Resistances of 0.41 Ω cm² and 0.39 Ω cm² were achieved with anodes containing Rh/CGO and Pd/CGO, respectively.