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Development of inositol-based antagonists for the D-myo-inositol 1,4,5-trisphosphate receptor

Research output: Contribution to journalArticlepeer-review

DOI

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Development of inositol-based antagonists for the D-myo-inositol 1,4,5-trisphosphate receptor. / Keddie, Neil S.; Ye, Yulin; Aslam, Tashfeen; Luyten, Tomas; Bello, Davide; Garnham, Clive; Bultynck, Geert; Galione, Antony; Conway, Stuart J.

In: Chemical Communications, Vol. 47, No. 1, 2011, p. 242-244.

Research output: Contribution to journalArticlepeer-review

Harvard

Keddie, NS, Ye, Y, Aslam, T, Luyten, T, Bello, D, Garnham, C, Bultynck, G, Galione, A & Conway, SJ 2011, 'Development of inositol-based antagonists for the D-myo-inositol 1,4,5-trisphosphate receptor', Chemical Communications, vol. 47, no. 1, pp. 242-244. https://doi.org/10.1039/c0cc03003a

APA

Keddie, N. S., Ye, Y., Aslam, T., Luyten, T., Bello, D., Garnham, C., Bultynck, G., Galione, A., & Conway, S. J. (2011). Development of inositol-based antagonists for the D-myo-inositol 1,4,5-trisphosphate receptor. Chemical Communications, 47(1), 242-244. https://doi.org/10.1039/c0cc03003a

Vancouver

Keddie NS, Ye Y, Aslam T, Luyten T, Bello D, Garnham C et al. Development of inositol-based antagonists for the D-myo-inositol 1,4,5-trisphosphate receptor. Chemical Communications. 2011;47(1):242-244. https://doi.org/10.1039/c0cc03003a

Author

Keddie, Neil S. ; Ye, Yulin ; Aslam, Tashfeen ; Luyten, Tomas ; Bello, Davide ; Garnham, Clive ; Bultynck, Geert ; Galione, Antony ; Conway, Stuart J. / Development of inositol-based antagonists for the D-myo-inositol 1,4,5-trisphosphate receptor. In: Chemical Communications. 2011 ; Vol. 47, No. 1. pp. 242-244.

Bibtex - Download

@article{38e9759ee25940eda886727ab9656239,
title = "Development of inositol-based antagonists for the D-myo-inositol 1,4,5-trisphosphate receptor",
abstract = "The syntheses of four D-myo-inositol 1,4,5-trisphosphate (InsP(3)) derivatives, incorporating phosphate bioisosteres at the 5-position, are reported. The methyl phosphate ester and sulfate derivatives retain InsP(3) receptor (InsP(3)R) agonist activity; the compounds that possess a methylphosphonate or a carboxymethyl moiety are InsP(3)R antagonists.",
keywords = "2-AMINOETHOXYDIPHENYL BORATE 2-APB, CALCIUM-RELEASE, MYOINOSITOL 1,4,5-TRISPHOSPHATE, 5-PHOSPHONATE ANALOGS, PARTIAL AGONISTS, CA2+ RELEASE, DERIVATIVES, PATHWAY, BINDING, NAADP",
author = "Keddie, {Neil S.} and Yulin Ye and Tashfeen Aslam and Tomas Luyten and Davide Bello and Clive Garnham and Geert Bultynck and Antony Galione and Conway, {Stuart J.}",
year = "2011",
doi = "10.1039/c0cc03003a",
language = "English",
volume = "47",
pages = "242--244",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "1",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Development of inositol-based antagonists for the D-myo-inositol 1,4,5-trisphosphate receptor

AU - Keddie, Neil S.

AU - Ye, Yulin

AU - Aslam, Tashfeen

AU - Luyten, Tomas

AU - Bello, Davide

AU - Garnham, Clive

AU - Bultynck, Geert

AU - Galione, Antony

AU - Conway, Stuart J.

PY - 2011

Y1 - 2011

N2 - The syntheses of four D-myo-inositol 1,4,5-trisphosphate (InsP(3)) derivatives, incorporating phosphate bioisosteres at the 5-position, are reported. The methyl phosphate ester and sulfate derivatives retain InsP(3) receptor (InsP(3)R) agonist activity; the compounds that possess a methylphosphonate or a carboxymethyl moiety are InsP(3)R antagonists.

AB - The syntheses of four D-myo-inositol 1,4,5-trisphosphate (InsP(3)) derivatives, incorporating phosphate bioisosteres at the 5-position, are reported. The methyl phosphate ester and sulfate derivatives retain InsP(3) receptor (InsP(3)R) agonist activity; the compounds that possess a methylphosphonate or a carboxymethyl moiety are InsP(3)R antagonists.

KW - 2-AMINOETHOXYDIPHENYL BORATE 2-APB

KW - CALCIUM-RELEASE

KW - MYOINOSITOL 1,4,5-TRISPHOSPHATE

KW - 5-PHOSPHONATE ANALOGS

KW - PARTIAL AGONISTS

KW - CA2+ RELEASE

KW - DERIVATIVES

KW - PATHWAY

KW - BINDING

KW - NAADP

U2 - 10.1039/c0cc03003a

DO - 10.1039/c0cc03003a

M3 - Article

VL - 47

SP - 242

EP - 244

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 1

ER -

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