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Differential regulation of ParaHox genes by retinoic acid in the invertebrate chordate amphioxus (Branchiostoma floridae).

Research output: Contribution to journalArticle

Standard

Differential regulation of ParaHox genes by retinoic acid in the invertebrate chordate amphioxus (Branchiostoma floridae). / Osborne, PW; Benoit, G; Laudet, V; Schubert, M; Ferrier, David Ellard Keith.

In: Developmental Biology, Vol. 327, 01.03.2009, p. 252-262.

Research output: Contribution to journalArticle

Harvard

Osborne, PW, Benoit, G, Laudet, V, Schubert, M & Ferrier, DEK 2009, 'Differential regulation of ParaHox genes by retinoic acid in the invertebrate chordate amphioxus (Branchiostoma floridae).' Developmental Biology, vol. 327, pp. 252-262. https://doi.org/doi:10.1016/j.ydbio.2008.11.027

APA

Osborne, PW., Benoit, G., Laudet, V., Schubert, M., & Ferrier, D. E. K. (2009). Differential regulation of ParaHox genes by retinoic acid in the invertebrate chordate amphioxus (Branchiostoma floridae). Developmental Biology, 327, 252-262. https://doi.org/doi:10.1016/j.ydbio.2008.11.027

Vancouver

Osborne PW, Benoit G, Laudet V, Schubert M, Ferrier DEK. Differential regulation of ParaHox genes by retinoic acid in the invertebrate chordate amphioxus (Branchiostoma floridae). Developmental Biology. 2009 Mar 1;327:252-262. https://doi.org/doi:10.1016/j.ydbio.2008.11.027

Author

Osborne, PW ; Benoit, G ; Laudet, V ; Schubert, M ; Ferrier, David Ellard Keith. / Differential regulation of ParaHox genes by retinoic acid in the invertebrate chordate amphioxus (Branchiostoma floridae). In: Developmental Biology. 2009 ; Vol. 327. pp. 252-262.

Bibtex - Download

@article{ad89f2989bdd4a588226c826ec8c30d0,
title = "Differential regulation of ParaHox genes by retinoic acid in the invertebrate chordate amphioxus (Branchiostoma floridae).",
abstract = "The ParaHox cluster is the evolutionary sister to the Hox cluster. Like the Hox cluster, the ParaHox cluster displays spatial and temporal regulation of the component genes along the anterior/posterior axis in a manner that correlates with the gene positions within the cluster (a feature called collinearity). The ParaHox cluster is however a simpler system to study because it is composed of only three genes. We provide a detailed analysis of the amphioxus ParaHox cluster and, for the first time in a single species, examine the regulation of the cluster in response to a single developmental signalling molecule, retinoic acid (RA). Embryos treated with either RA or RA antagonist display altered ParaHox gene expression: AmphiGsx expression shifts in the neural tube, and the endodermal boundary between AmphiXlox and AmphiCdx shifts its anterior/posterior position. We identified several putative retinoic acid response elements and in vitro assays suggest some may participate in RA regulation of the ParaHox genes. By comparison to vertebrate ParaHox gene regulation we explore the evolutionary implications. This work highlights how insights into the regulation and evolution of more complex vertebrate arrangements can be obtained through studies of a simpler, Unduplicated amphioxus gene cluster. (C) 2008 Elsevier Inc. All rights reserved.",
keywords = "Amphioxus, Retinoic acid, Gsx, Xlox, Cdx, ParaHox, Gene regulation, Evolution, Endoderm patterning, EMBRYONIC STEM-CELLS, HOX GENES, SEGMENTAL EXPRESSION, SIGNALING PATHWAY, NUCLEAR RECEPTORS, NERVOUS-SYSTEM, NEURAL CREST, IN-VIVO, CLUSTER, MOUSE",
author = "PW Osborne and G Benoit and V Laudet and M Schubert and Ferrier, {David Ellard Keith}",
year = "2009",
month = "3",
day = "1",
doi = "doi:10.1016/j.ydbio.2008.11.027",
language = "English",
volume = "327",
pages = "252--262",
journal = "Developmental Biology",
issn = "0012-1606",
publisher = "Academic Press Inc.",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Differential regulation of ParaHox genes by retinoic acid in the invertebrate chordate amphioxus (Branchiostoma floridae).

AU - Osborne, PW

AU - Benoit, G

AU - Laudet, V

AU - Schubert, M

AU - Ferrier, David Ellard Keith

PY - 2009/3/1

Y1 - 2009/3/1

N2 - The ParaHox cluster is the evolutionary sister to the Hox cluster. Like the Hox cluster, the ParaHox cluster displays spatial and temporal regulation of the component genes along the anterior/posterior axis in a manner that correlates with the gene positions within the cluster (a feature called collinearity). The ParaHox cluster is however a simpler system to study because it is composed of only three genes. We provide a detailed analysis of the amphioxus ParaHox cluster and, for the first time in a single species, examine the regulation of the cluster in response to a single developmental signalling molecule, retinoic acid (RA). Embryos treated with either RA or RA antagonist display altered ParaHox gene expression: AmphiGsx expression shifts in the neural tube, and the endodermal boundary between AmphiXlox and AmphiCdx shifts its anterior/posterior position. We identified several putative retinoic acid response elements and in vitro assays suggest some may participate in RA regulation of the ParaHox genes. By comparison to vertebrate ParaHox gene regulation we explore the evolutionary implications. This work highlights how insights into the regulation and evolution of more complex vertebrate arrangements can be obtained through studies of a simpler, Unduplicated amphioxus gene cluster. (C) 2008 Elsevier Inc. All rights reserved.

AB - The ParaHox cluster is the evolutionary sister to the Hox cluster. Like the Hox cluster, the ParaHox cluster displays spatial and temporal regulation of the component genes along the anterior/posterior axis in a manner that correlates with the gene positions within the cluster (a feature called collinearity). The ParaHox cluster is however a simpler system to study because it is composed of only three genes. We provide a detailed analysis of the amphioxus ParaHox cluster and, for the first time in a single species, examine the regulation of the cluster in response to a single developmental signalling molecule, retinoic acid (RA). Embryos treated with either RA or RA antagonist display altered ParaHox gene expression: AmphiGsx expression shifts in the neural tube, and the endodermal boundary between AmphiXlox and AmphiCdx shifts its anterior/posterior position. We identified several putative retinoic acid response elements and in vitro assays suggest some may participate in RA regulation of the ParaHox genes. By comparison to vertebrate ParaHox gene regulation we explore the evolutionary implications. This work highlights how insights into the regulation and evolution of more complex vertebrate arrangements can be obtained through studies of a simpler, Unduplicated amphioxus gene cluster. (C) 2008 Elsevier Inc. All rights reserved.

KW - Amphioxus

KW - Retinoic acid

KW - Gsx

KW - Xlox

KW - Cdx

KW - ParaHox

KW - Gene regulation

KW - Evolution

KW - Endoderm patterning

KW - EMBRYONIC STEM-CELLS

KW - HOX GENES

KW - SEGMENTAL EXPRESSION

KW - SIGNALING PATHWAY

KW - NUCLEAR RECEPTORS

KW - NERVOUS-SYSTEM

KW - NEURAL CREST

KW - IN-VIVO

KW - CLUSTER

KW - MOUSE

UR - http://www.scopus.com/inward/record.url?scp=59849112932&partnerID=8YFLogxK

U2 - doi:10.1016/j.ydbio.2008.11.027

DO - doi:10.1016/j.ydbio.2008.11.027

M3 - Article

VL - 327

SP - 252

EP - 262

JO - Developmental Biology

T2 - Developmental Biology

JF - Developmental Biology

SN - 0012-1606

ER -

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ID: 436064