Skip to content

Research at St Andrews

Differentiating the functional contributions of resting connectivity networks to memory decision-making: fMRI support for multi-stage control processes

Research output: Contribution to journalArticle

DOI

Open Access permissions

Open

Author(s)

Ravi Dev Mill, Ian Cavin, Akira Robert O'Connor

School/Research organisations

Abstract

Neural substrates of memory control are engaged when participants encounter unexpected mnemonic stimuli (e.g., a new word when told to expect an old word). The present fMRI study (n = 18) employed the likelihood cueing recognition task to elucidate the role of functional connectivity (fcMRI) networks in supporting memory control processes engaged by these unexpected events. Conventional task-evoked BOLD analyses recovered a memory control network similar to that previously reported, comprising medial prefrontal, lateral prefrontal, and inferior parietal regions. These were split by their differential affiliation to distinct fcMRI networks (“conflict detection” and “confirmatory retrieval” networks). Subsequent ROI analyses clarified the functional significance of this connectivity differentiation, with “conflict” network-affiliated regions specifically sensitive to cue strength, but not to response confidence, and “retrieval” network-affiliated regions showing the opposite pattern. BOLD time course analyses corroborated the segregation of memory control regions into “early” conflict detection and “late” retrieval analysis, with both processes underlying the allocation of memory control. Response specificity and time course findings were generalized beyond task-recruited ROIs to clusters within the large-scale fcMRI networks, suggesting that this connectivity architecture could underlie efficient processing of distinct processes within cognitive tasks. The findings raise important parallels between prevailing theories of memory and cognitive control.
Close

Details

Original languageEnglish
Pages (from-to)1617-1632
JournalJournal of Cognitive Neuroscience
Volume27
Issue number8
Early online date24 Mar 2015
DOIs
StatePublished - 29 Jun 2015

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Déjà vu experiences in anxiety

    Wells, C., O'Connor, A. R. & Moulin, C. 1 Nov 2018 In : Memory. In press

    Research output: Contribution to journalArticle

  2. fMRI evidence supporting the role of memory conflict in the déjà vu experience

    Urquhart, J. A., Sivakumaran, M. H., Macfarlane, J. A. & O'Connor, A. R. 20 Sep 2018 In : Memory. Latest Articles

    Research output: Contribution to journalArticle

  3. How accurate are runners’ prospective predictions of their race times?

    Liverakos, K., McIntosh, K., Moulin, C. & O'Connor, A. R. 1 Aug 2018 In : PLoS One. 13, 8, 24 p., e0200744

    Research output: Contribution to journalArticle

  4. The discrimination ratio derived from novel object recognition tasks as a measure of recognition memory sensitivity, not bias

    Sivakumaran, M. H., MacKenzie, A. K., Callan, I. R., Ainge, J. A. & O'Connor, A. R. 1 Aug 2018 In : Scientific Reports. 8, 11579

    Research output: Contribution to journalArticle

  5. Constructing and model-fitting receiver operator characteristics using continuous data

    Urquhart, J. A. & O'Connor, A. R. 20 Apr 2018 In : PsyArxiv.

    Research output: Contribution to journalArticle

Related by journal

  1. Role of oculoproprioception in coding the locus of attention

    Odoj, B. & Balslev, D. Mar 2016 In : Journal of Cognitive Neuroscience. 28, 3, p. 517-528

    Research output: Contribution to journalArticle

  2. Abnormal center-periphery gradient in spatial attention in simultanagnosia

    Balslev, D., Odoj, B., Rennig, J. & Karnath, H-O. 4 Jun 2014 In : Journal of Cognitive Neuroscience. p. 1-11 11 p.

    Research output: Contribution to journalArticle

  3. Short-term motor training, but not observational training, alters neurocognitive mechanisms of action processing in infancy

    Gerson, S., Bekkering, H. & Hunnius, S. 2014 In : Journal of Cognitive Neuroscience. In press

    Research output: Contribution to journalArticle

  4. Visual sensitivity shifts with perceived eye position

    Odoj, B. & Balslev, D. 2013 In : Journal of Cognitive Neuroscience. 25, 7, p. 1180-1189 10 p.

    Research output: Contribution to journalArticle

ID: 172789992