Skip to content

Research at St Andrews

University > Research portal > Research publications > Diverse immune functions of hemocyanins

Diverse immune functions of hemocyanins

Research output: Contribution to journal › Article

DOI

Author(s)

Christopher J. Coates, Jacqueline Nairn

School/Research organisations

Abstract

Substantial evidence gathered recently has revealed the multiple functionalities of hemocyanin. Contrary to previous claims that this ancient protein is involved solely in oxygen transport within the hemolymph of invertebrates, hemocyanin and hemocyanin-derived peptides have been linked to key aspects of innate immunity, in particular, antiviral and phenoloxidase-like activities. Both phenoloxidase and hemocyanin belong to the family of type-3 copper proteins and share a high degree of sequence homology. While the importance of phenoloxidase in immunity and development is well characterised, the contribution of hemocyanin to biological defence systems within invertebrates is not recognised widely.

This review focusses on the conversion of hemocyanin into a phenoloxidase-like enzyme and the array of hemocyanin-derived immune responses documented to date.
Close
More...

Details

Original languageEnglish
Pages (from-to)43-55
JournalDevelopmental and Comparative Immunology
Volume45
Issue number1
DOIs
Publication statusPublished - Jul 2014

    Research areas

  • Multifunctional, Hemocyanin, Phenoloxidase, Microbicidal, Innate Immunity, Hemoglobin

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Isolation, identification and characterisation of ballan wrasse Labrus bergylta plasma pigment

    Clark, W., Leclercq, E., Migaud, H., Nairn, J. & Davie, A., Oct 2016, In : Journal of Fish Biology. 89, 4, p. 2070-2084 15 p.

    Research output: Contribution to journal › Article

  2. Mushroom tyrosinase: a model system to combine experimental investigation of enzyme-catalyzed reactions, data handling using R, and enzyme-inhibitor structural studies

    Nairn, R., Cresswell, W. & Nairn, J., Sep 2015, In : Biochemistry and Molecular Biology Education . 43, 5, p. 370-376

    Research output: Contribution to journal › Article

  3. Subject Benchmark Statement:Biosciences

    Nairn, J., 2015, QAA for Higher Education.

    Research output: Book/Report › Commissioned report

  4. A putative link between phagocytosis-induced apoptosis and hemocyanin-derived phenoloxidase activation

    Coates, C. J., Whalley, T., Wyman, M. & Nairn, J., Nov 2013, In : Apoptosis. 18, 11, p. 1319-1331 13 p.

    Research output: Contribution to journal › Article

  5. Hemocyanin-derived phenoloxidase activity: A contributing factor to hyperpigmentation in Nephrops norvegicus

    Coates, C. J. & Nairn, J., 15 Sep 2013, In : Food Chemistry. 140, 1-2, p. 361-369 9 p.

    Research output: Contribution to journal › Article

Related by journal

  1. Unusual tissue distribution of carcinin, an antibacterial crustin, in the crab, Carcinus maenas, reveals its multi-functionality

    Suleiman, S., Smith, V. J. & Dyrynda, E. A., Nov 2017, In : Developmental and Comparative Immunology. 76, p. 274-284

    Research output: Contribution to journal › Article

  2. Isolation and in vitro characterisation of prohaemocytes from the spider crab, Hyas araneus (L.)

    Roulston, C. & Smith, V. J., May 2011, In : Developmental and Comparative Immunology. 35, 5, p. 537-544

    Research output: Contribution to journal › Article

  3. Possible role of phosphatidylserine-hemocyanin interaction in the innate immune response of Limulus polyphemus

    Coates, C. J., Kelly, S. M. & Nairn, J., Feb 2011, In : Developmental and Comparative Immunology. 35, 2, p. 155-163 9 p.

    Research output: Contribution to journal › Article

  4. Expression of antimicrobial peptides from Hyas araneus hemocytes following bacterial challenge in vitro

    Sperstad, S., Smith, V. J. & Stensvag, K., 2010, In : Developmental and Comparative Immunology. 34, p. 618–624

    Research output: Contribution to journal › Article

Related by journal

  1. Developmental and Comparative Immunology (Journal)

    Val Smith (Member of editorial board)
    2012 → 2018

    Activity: Publication peer-review and editorial work types › Peer review of manuscripts

  2. Developmental and Comparative Immunology (Journal)

    Val Smith (Member of editorial board)
    2008 → 2015

    Activity: Publication peer-review and editorial work types › Peer review of manuscripts

ID: 108819741

Top