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Do cnidarians have a ParaHox cluster? Analysis of synteny around a Nematostella homeobox gene cluster.

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Do cnidarians have a ParaHox cluster? Analysis of synteny around a Nematostella homeobox gene cluster. / Hui, J.H.L.; Holland, P.W.H.; Ferrier, David Ellard Keith.

In: Evolution and Development, Vol. 10, 11.2008, p. 725-730.

Research output: Contribution to journalArticle

Harvard

Hui, JHL, Holland, PWH & Ferrier, DEK 2008, 'Do cnidarians have a ParaHox cluster? Analysis of synteny around a Nematostella homeobox gene cluster.' Evolution and Development, vol. 10, pp. 725-730. https://doi.org/10.1111/j.1525-142X.2008.00286.x

APA

Hui, J. H. L., Holland, P. W. H., & Ferrier, D. E. K. (2008). Do cnidarians have a ParaHox cluster? Analysis of synteny around a Nematostella homeobox gene cluster. Evolution and Development, 10, 725-730. https://doi.org/10.1111/j.1525-142X.2008.00286.x

Vancouver

Hui JHL, Holland PWH, Ferrier DEK. Do cnidarians have a ParaHox cluster? Analysis of synteny around a Nematostella homeobox gene cluster. Evolution and Development. 2008 Nov;10:725-730. https://doi.org/10.1111/j.1525-142X.2008.00286.x

Author

Hui, J.H.L. ; Holland, P.W.H. ; Ferrier, David Ellard Keith. / Do cnidarians have a ParaHox cluster? Analysis of synteny around a Nematostella homeobox gene cluster. In: Evolution and Development. 2008 ; Vol. 10. pp. 725-730.

Bibtex - Download

@article{d1bb4ec0f06b417083fdcbfa3a6be37f,
title = "Do cnidarians have a ParaHox cluster? Analysis of synteny around a Nematostella homeobox gene cluster.",
abstract = "The Hox gene cluster is renowned for its role in developmental patterning of embryogenesis along the anterior-posterior axis of bilaterians. Its supposed evolutionary sister or paralog, the ParaHox cluster, is composed of Gsx, Xlox, and Cdx, and also has important roles in anterior-posterior development. There is a debate as to whether the cnidarians, as an outgroup to bilaterians, contain true Hox and ParaHox genes, or instead the Hox-like gene complement of cnidarians arose from independent duplications to those that generated the genes of the bilaterian Hox and ParaHox clusters. A recent whole genome analysis of the cnidarian Nematostella vectensis found conserved synteny between this cnidarian and vertebrates, including a region of synteny between the putative Hox cluster of N. vectensis and the Hox clusters of vertebrates. No syntenic region was identified around a potential cnidarian ParaHox cluster. Here we use different approaches to identify a genomic region in N. vectensis that is syntenic with the bilaterian ParaHox cluster. This proves that the duplication that gave rise to the Hox and ParaHox regions of bilaterians occurred before the origin of cnidarians, and the cnidarian N. vectensis has bona fide Hox and ParaHox loci.",
keywords = "SEA-ANEMONE, HOX GENES, EVOLUTION, PROTOHOX",
author = "J.H.L. Hui and P.W.H. Holland and Ferrier, {David Ellard Keith}",
year = "2008",
month = "11",
doi = "10.1111/j.1525-142X.2008.00286.x",
language = "English",
volume = "10",
pages = "725--730",
journal = "Evolution and Development",
issn = "1520-541X",
publisher = "John Wiley & Sons, Ltd (10.1111)",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Do cnidarians have a ParaHox cluster? Analysis of synteny around a Nematostella homeobox gene cluster.

AU - Hui, J.H.L.

AU - Holland, P.W.H.

AU - Ferrier, David Ellard Keith

PY - 2008/11

Y1 - 2008/11

N2 - The Hox gene cluster is renowned for its role in developmental patterning of embryogenesis along the anterior-posterior axis of bilaterians. Its supposed evolutionary sister or paralog, the ParaHox cluster, is composed of Gsx, Xlox, and Cdx, and also has important roles in anterior-posterior development. There is a debate as to whether the cnidarians, as an outgroup to bilaterians, contain true Hox and ParaHox genes, or instead the Hox-like gene complement of cnidarians arose from independent duplications to those that generated the genes of the bilaterian Hox and ParaHox clusters. A recent whole genome analysis of the cnidarian Nematostella vectensis found conserved synteny between this cnidarian and vertebrates, including a region of synteny between the putative Hox cluster of N. vectensis and the Hox clusters of vertebrates. No syntenic region was identified around a potential cnidarian ParaHox cluster. Here we use different approaches to identify a genomic region in N. vectensis that is syntenic with the bilaterian ParaHox cluster. This proves that the duplication that gave rise to the Hox and ParaHox regions of bilaterians occurred before the origin of cnidarians, and the cnidarian N. vectensis has bona fide Hox and ParaHox loci.

AB - The Hox gene cluster is renowned for its role in developmental patterning of embryogenesis along the anterior-posterior axis of bilaterians. Its supposed evolutionary sister or paralog, the ParaHox cluster, is composed of Gsx, Xlox, and Cdx, and also has important roles in anterior-posterior development. There is a debate as to whether the cnidarians, as an outgroup to bilaterians, contain true Hox and ParaHox genes, or instead the Hox-like gene complement of cnidarians arose from independent duplications to those that generated the genes of the bilaterian Hox and ParaHox clusters. A recent whole genome analysis of the cnidarian Nematostella vectensis found conserved synteny between this cnidarian and vertebrates, including a region of synteny between the putative Hox cluster of N. vectensis and the Hox clusters of vertebrates. No syntenic region was identified around a potential cnidarian ParaHox cluster. Here we use different approaches to identify a genomic region in N. vectensis that is syntenic with the bilaterian ParaHox cluster. This proves that the duplication that gave rise to the Hox and ParaHox regions of bilaterians occurred before the origin of cnidarians, and the cnidarian N. vectensis has bona fide Hox and ParaHox loci.

KW - SEA-ANEMONE

KW - HOX GENES

KW - EVOLUTION

KW - PROTOHOX

UR - http://www.scopus.com/inward/record.url?scp=55049140961&partnerID=8YFLogxK

U2 - 10.1111/j.1525-142X.2008.00286.x

DO - 10.1111/j.1525-142X.2008.00286.x

M3 - Article

VL - 10

SP - 725

EP - 730

JO - Evolution and Development

T2 - Evolution and Development

JF - Evolution and Development

SN - 1520-541X

ER -

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