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Efficient singlet oxygen photogeneration by zinc porphyrin-dimers upon one- and two-photon excitation

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Leszek Mateusz Mazur , Thomas Roland, Stephanie Leroy-Lhez, Vincent Sol, Marek Samoc, Ifor David William Samuel, Katarzyna Matczyszyn

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The development of photodynamic therapy at depth requires photosensitizers which have both sufficient quantum yield for singlet oxygen generation and strong two photon absorption. Here we show that this can be achieved by conjugated linkage of zinc porphyrins to make dimers. We determined the quantum yield of generation of 1O2, φΔ , by measuring emission at 1270 nm using a near infra-red streak camera and found it to increase from 15% for a single porphyrin unit to 27 47% for the dimers with a conjugated linker. Then, we measured the spectra of two-photon absorption cross section, σ2, by a focus-tunable Z scan method, which allows for nondestructive investigation of light-sensitive materials. We observed a strong enhancement of the two photon absorption coefficient in the dimers, especially those with an alkyne linker. These results lead to an excellent figure of merit for two photon production of singlet oxygen (expressed by the product σ2xφΔ) in the porphyrin dimers, of around 3700 GM, which is very promising for applications involving treatment of deep tumors by photodynamic therapy.


Original languageEnglish
Pages (from-to)4271-4277
Number of pages7
JournalJournal of Physical Chemistry B
Issue number19
Early online date5 Mar 2019
Publication statusPublished - 16 May 2019

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