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Efficient synthesis of novel chalcogen-containing derivatives of DNA nucleobases

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Abstract

The formation of a library of chalcogen-containing DNA nucleobase derivatives is presented. Reacting easily accessible 9-(2-bromoethyl)adenine with chalcogen-containing nucleophilic reagents led to a series of novel heteroatom derivatives incorporating S, Se and Te atoms prepared in satisfactory yields. Two representative X-ray structures are reported
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Original languageEnglish
Pages (from-to)1792-1798
JournalTetrahedron
Volume71
Issue number12
Early online date7 Feb 2015
DOIs
Publication statusPublished - 25 Mar 2015

    Research areas

  • DNA nucleobases, 9-(2-Bromoethyl)adenine, Adenine derivatives, Chalcogens, Woollins’ reagent

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