Skip to content

Research at St Andrews

Erythritol attenuates postprandial blood glucose by inhibiting α-glucosidase

Research output: Contribution to journalArticle

Author(s)

Huaixiu Wen, Bowen Tang, Alan J. Stewart, Yanduo Tao, Yun Shao, Yulei Cui, Huilan Yue, Jinjin Pei, Zenggen Liu, Lijuan Mei, Ruitao Yu, Lei Jiang

School/Research organisations

Abstract

Diabetes mellitus (DM) is a serious metabolic disorder where impaired postprandial blood glucose regulation often leads to severe health complications. The natural chemical, erythritol is a C4 polyol approved by FDA for use as a sweetener. Here we examined a potential role for erythritol in the control of postprandial blood glucose levels in DM. An anti-postprandial hyperglycemia effect upon erythritol administration (500 mg kg-1) was demonstrated in alloxan-induced DM model mice by monitoring changes in blood glucose after intragastric administration of drugs and starch. We also found that erythritol most likely exerts its anti-postprandial hyperglycemic activities by inhibiting α-glucosidase in a competitive manner. This was supported by enzyme activity assays and molecular modelling experiments. In the latter experiments it was possible to successful dock erythritol into the catalytic pocket of α-glucosidase, with the resultant interaction likely to be driven by electrostatic interactions involving Asp 215, Asp69 and Arg446 residues. This study suggests that erythritol may not only serve as a glucose substitute but may also be a useful agent in the treatment of diabetes mellitus to help manage postprandial blood glucose levels.
Close

Details

Original languageEnglish
Pages (from-to)1401-1407
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume66
Issue number6
Early online date23 Jan 2018
DOIs
Publication statusPublished - 14 Feb 2018

    Research areas

  • Diabetes mellitus, Postprandial blood glucose, Erythritol, α-glucosidase

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. A metalloproteomic analysis of interactions between plasma proteins and zinc: elevated fatty acid levels affect zinc distribution

    Coverdale, J. P. C., Barnett, J. P., Adamu, A. H., Griffiths, E. J., Stewart, A. J. & Blindauer, C. A., 12 Sep 2019, (Accepted/In press) In : Metallomics.

    Research output: Contribution to journalArticle

  2. Plasma non-esterified fatty acids contribute to increased coagulability in type-2 diabetes through altered plasma zinc speciation

    Sobczak, A. I. S., Katundu, K. G. H., Phoenix, F. A., Khazaipoul, S., Yu, R., Lampiao, F., Stefanowicz, F., Blindauer, C. A., Pitt, S. J., Smith, T. K., Ajjan, R. A. & Stewart, A. J., 28 Aug 2019, In : biorxiv. 38 p.

    Research output: Contribution to journalArticle

  3. Changes in plasma free fatty acids associated with type-2 diabetes

    Sobczak, A. I. S., Blindauer, C. A. & Stewart, A. J., 28 Aug 2019, In : Nutrients. 11, 9, 42 p., 2022.

    Research output: Contribution to journalReview article

  4. Sub-micromolar pulse dipolar EPR spectroscopy reveals increasing CuII-labelling of double-histidine motifs with lower temperature

    Wort, J. L., Ackermann, K., Giannoulis, A., Stewart, A. J., Norman, D. G. & Bode, B. E., 19 Aug 2019, In : Angewandte Chemie - International Edition. 58, 34, p. 11681-11685 5 p.

    Research output: Contribution to journalArticle

  5. Sub-micromolar pulse dipolar EPR spectroscopy reveals increasing CuII-labelling of double-histidine motifs with lower temperature

    Wort, J., Ackermann, K., Giannoulis, A., Stewart, A. J., Norman, D. & Bode, B. E., 19 Aug 2019, In : Angewandte Chemie. 131, 34, p. 11807-11811 6 p.

    Research output: Contribution to journalArticle

Related by journal

  1. Biochemical and structural factors contributing to seasonal variation in the texture of farmed halibut (Hippoglossus hippoglossus L.) flesh.

    Johnston, I. A., Solberg, C., Sirnes, E. & Johnston, I. A., 11 Jul 2007, In : Journal of Agricultural and Food Chemistry. 55, p. 5803-5808 6 p.

    Research output: Contribution to journalArticle

  2. An international quality assurance scheme for the quantitation of daidzein and genistein in food, urine and plasma

    Key, P. E., Finglas, P. M., Coldham, N., Botting, N., Oldfield, M. F. & Wood, R., May 2006, In : Journal of Agricultural and Food Chemistry. 96, p. 261-272 12 p.

    Research output: Contribution to journalArticle

ID: 252180879