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Establishing the psychometric underpinning of cognition measures for clinical trials of Alzheimer's disease and its precursors: a new approach

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Author(s)

Holly B Posner, Stefan Cano, Maria C Carrillo, Ola Selnes, Yaakov Stern, Ronald G Thomas, John Zajicek, Jeremy Hobart, Alzheimer's Disease Neuroimaging Initiative

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Abstract

The Alzheimer's disease (AD) Cognitive Behavior Section (ADAS-Cog) is the most commonly used cognitive test in clinical trials of AD. Recent trials have focused on people earlier in the course of disease; however, there are concerns about using the ADAS-Cog at this crucial stage. Using data from the Alzheimer's disease Neuroimaging Initiative study, we used a range of traditional psychometric tests to evaluate those concerns. This issue of Alzheimer's & Dementia includes two articles that evaluate the ADAS-Cog. These articles report evaluations using two psychometric approaches: traditional methods and new methods. In this review, we provide accompanying background information to this program of research.

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Details

Original languageEnglish
Pages (from-to)S56-60
JournalAlzheimer's and Dementia
Volume9
Issue number1 Suppl
DOIs
Publication statusPublished - Feb 2013

    Research areas

  • Alzheimer Disease, Clinical Trials as Topic, Humans, Neuropsychological Tests, Psychometrics, Research Design

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