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Ethnic differences in male reproductive hormones and relationships with adiposity and insulin resistance in older men

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DOI

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Ethnic differences in male reproductive hormones and relationships with adiposity and insulin resistance in older men. / Eendebak, Robert J. A. H.; Swiecicka, Agnieszka; Gromski, Piotr S.; Pye, Stephen R.; O'Neill, Terence W.; Marshall, Alan; Keevil, Brian G.; Tampubolon, Gindo; Goodacre, Royston; Wu, Frederick C. W.; Rutter, Martin K.

In: Clinical Endocrinology, Vol. 86, No. 5, 05.2017, p. 660-668.

Research output: Contribution to journalArticle

Harvard

Eendebak, RJAH, Swiecicka, A, Gromski, PS, Pye, SR, O'Neill, TW, Marshall, A, Keevil, BG, Tampubolon, G, Goodacre, R, Wu, FCW & Rutter, MK 2017, 'Ethnic differences in male reproductive hormones and relationships with adiposity and insulin resistance in older men' Clinical Endocrinology, vol 86, no. 5, pp. 660-668. DOI: 10.1111/cen.13305

APA

Eendebak, R. J. A. H., Swiecicka, A., Gromski, P. S., Pye, S. R., O'Neill, T. W., Marshall, A., ... Rutter, M. K. (2017). Ethnic differences in male reproductive hormones and relationships with adiposity and insulin resistance in older men. Clinical Endocrinology, 86(5), 660-668. DOI: 10.1111/cen.13305

Vancouver

Eendebak RJAH, Swiecicka A, Gromski PS, Pye SR, O'Neill TW, Marshall A et al. Ethnic differences in male reproductive hormones and relationships with adiposity and insulin resistance in older men. Clinical Endocrinology. 2017 May;86(5):660-668. Available from, DOI: 10.1111/cen.13305

Author

Eendebak, Robert J. A. H.; Swiecicka, Agnieszka; Gromski, Piotr S.; Pye, Stephen R.; O'Neill, Terence W.; Marshall, Alan; Keevil, Brian G.; Tampubolon, Gindo; Goodacre, Royston; Wu, Frederick C. W.; Rutter, Martin K. / Ethnic differences in male reproductive hormones and relationships with adiposity and insulin resistance in older men.

In: Clinical Endocrinology, Vol. 86, No. 5, 05.2017, p. 660-668.

Research output: Contribution to journalArticle

Bibtex - Download

@article{f10d3141c5034425a787e8d2bb53bc61,
title = "Ethnic differences in male reproductive hormones and relationships with adiposity and insulin resistance in older men",
abstract = "Objectives: To assess ethnic differences in male reproductive hormone levels and to determine if any differences are explained by adiposity, insulin resistance (IR), or comorbidities in older men.Design: Multi-ethnic cross-sectional observational study.Participants: Community dwelling middle-aged and elderly men residing in the U.K. aged 40-84 years of South Asian (SA; n=180), White European (WE; n=328) or African Caribbean (AC; n=166) origin.Observations: Measured testosterone (T), calculated free T (cFT), SHBG, and LH in SA, WE and AC men along with an assessment of body composition, IR, life-style factors and medical conditions.Results: Age-adjusted mean T and cFT levels were lower in SA men when compared to WE and AC men (mean (SEM) T: SA: 14·0 ± 0·4; WE: 17·1 ± 0·3; AC: 17·2 ± 0·5 nmol/l, P < 0·001; cFT: SA: 283 ± 7; WE: 313 ± 5; AC: 314 ± 8 pmol/l, P < 0·006). Compared to WE and AC men, SA men had higher levels of body fat, IR, comorbidities and diabetes. After adjusting for body fat, IR and other confounders, T levels in SA men remained lower than in WE men (P = 0·04) but ethnic differences in cFT became nonsignificant. LH levels were higher in SA than WE men in age-adjusted and fully adjusted models.Conclusions: T and cFT are lower in SA men than in WE and AC men. Whether ethnic-specific reference ranges for T and cFT might be appropriate in clinical practice requires further investigation. Ethnic differences in cFT, but not T, appear to be, more readily, explained by ethnic differences in adiposity, thus providing insights into potential pathophysiological mechanisms.",
author = "Eendebak, {Robert J. A. H.} and Agnieszka Swiecicka and Gromski, {Piotr S.} and Pye, {Stephen R.} and O'Neill, {Terence W.} and Alan Marshall and Keevil, {Brian G.} and Gindo Tampubolon and Royston Goodacre and Wu, {Frederick C. W.} and Rutter, {Martin K.}",
note = "RJAHE is supported by a Biotechnology and Biological Sciences Research Council – Doctoral Training Partnership (BBSRC-DTP) PhD-fellowship, and is grateful for receiving support from the Fundatie van de Vrijvrouwe van Renswoude and Scholten-Cordes scholarship foundations. All authors would like to thank the men who participated in the HUSERMET-project (10) and are grateful for funding of the HUSERMET project by the U.K. BBSRC (Grant number: BB/C519038/1) and U.K. Medical Research Council, with contributions from Astra-Zeneca and GlaxoSmithKline.",
year = "2017",
month = "5",
doi = "10.1111/cen.13305",
volume = "86",
pages = "660--668",
journal = "Clinical Endocrinology",
issn = "0300-0664",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Ethnic differences in male reproductive hormones and relationships with adiposity and insulin resistance in older men

AU - Eendebak,Robert J. A. H.

AU - Swiecicka,Agnieszka

AU - Gromski,Piotr S.

AU - Pye,Stephen R.

AU - O'Neill,Terence W.

AU - Marshall,Alan

AU - Keevil,Brian G.

AU - Tampubolon,Gindo

AU - Goodacre,Royston

AU - Wu,Frederick C. W.

AU - Rutter,Martin K.

N1 - RJAHE is supported by a Biotechnology and Biological Sciences Research Council – Doctoral Training Partnership (BBSRC-DTP) PhD-fellowship, and is grateful for receiving support from the Fundatie van de Vrijvrouwe van Renswoude and Scholten-Cordes scholarship foundations. All authors would like to thank the men who participated in the HUSERMET-project (10) and are grateful for funding of the HUSERMET project by the U.K. BBSRC (Grant number: BB/C519038/1) and U.K. Medical Research Council, with contributions from Astra-Zeneca and GlaxoSmithKline.

PY - 2017/5

Y1 - 2017/5

N2 - Objectives: To assess ethnic differences in male reproductive hormone levels and to determine if any differences are explained by adiposity, insulin resistance (IR), or comorbidities in older men.Design: Multi-ethnic cross-sectional observational study.Participants: Community dwelling middle-aged and elderly men residing in the U.K. aged 40-84 years of South Asian (SA; n=180), White European (WE; n=328) or African Caribbean (AC; n=166) origin.Observations: Measured testosterone (T), calculated free T (cFT), SHBG, and LH in SA, WE and AC men along with an assessment of body composition, IR, life-style factors and medical conditions.Results: Age-adjusted mean T and cFT levels were lower in SA men when compared to WE and AC men (mean (SEM) T: SA: 14·0 ± 0·4; WE: 17·1 ± 0·3; AC: 17·2 ± 0·5 nmol/l, P < 0·001; cFT: SA: 283 ± 7; WE: 313 ± 5; AC: 314 ± 8 pmol/l, P < 0·006). Compared to WE and AC men, SA men had higher levels of body fat, IR, comorbidities and diabetes. After adjusting for body fat, IR and other confounders, T levels in SA men remained lower than in WE men (P = 0·04) but ethnic differences in cFT became nonsignificant. LH levels were higher in SA than WE men in age-adjusted and fully adjusted models.Conclusions: T and cFT are lower in SA men than in WE and AC men. Whether ethnic-specific reference ranges for T and cFT might be appropriate in clinical practice requires further investigation. Ethnic differences in cFT, but not T, appear to be, more readily, explained by ethnic differences in adiposity, thus providing insights into potential pathophysiological mechanisms.

AB - Objectives: To assess ethnic differences in male reproductive hormone levels and to determine if any differences are explained by adiposity, insulin resistance (IR), or comorbidities in older men.Design: Multi-ethnic cross-sectional observational study.Participants: Community dwelling middle-aged and elderly men residing in the U.K. aged 40-84 years of South Asian (SA; n=180), White European (WE; n=328) or African Caribbean (AC; n=166) origin.Observations: Measured testosterone (T), calculated free T (cFT), SHBG, and LH in SA, WE and AC men along with an assessment of body composition, IR, life-style factors and medical conditions.Results: Age-adjusted mean T and cFT levels were lower in SA men when compared to WE and AC men (mean (SEM) T: SA: 14·0 ± 0·4; WE: 17·1 ± 0·3; AC: 17·2 ± 0·5 nmol/l, P < 0·001; cFT: SA: 283 ± 7; WE: 313 ± 5; AC: 314 ± 8 pmol/l, P < 0·006). Compared to WE and AC men, SA men had higher levels of body fat, IR, comorbidities and diabetes. After adjusting for body fat, IR and other confounders, T levels in SA men remained lower than in WE men (P = 0·04) but ethnic differences in cFT became nonsignificant. LH levels were higher in SA than WE men in age-adjusted and fully adjusted models.Conclusions: T and cFT are lower in SA men than in WE and AC men. Whether ethnic-specific reference ranges for T and cFT might be appropriate in clinical practice requires further investigation. Ethnic differences in cFT, but not T, appear to be, more readily, explained by ethnic differences in adiposity, thus providing insights into potential pathophysiological mechanisms.

UR - http://onlinelibrary.wiley.com/doi/10.1111/cen.13305/abstract#footer-support-info

U2 - 10.1111/cen.13305

DO - 10.1111/cen.13305

M3 - Article

VL - 86

SP - 660

EP - 668

JO - Clinical Endocrinology

T2 - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

IS - 5

ER -

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