Skip to content

Research at St Andrews

Evaluating multicenter DTI data in Huntington's disease on site specific effects: an ex post facto approach

Research output: Contribution to journalArticle

Author(s)

Hans-Peter Müller, Georg Grön, Reiner Sprengelmeyer, Jan Kassubek, Albert C. Ludolph, Nicola Hobbs, James Cole, Raymund A.C. Roos, Alexandra Duerr, Sarah J. Tabrizi, G. Bernhard Landwehrmeyer, Sigurd D. Süssmuth

School/Research organisations

Abstract

Purpose: Assessment of the feasibility to average diffusion tensor imaging (DTI) metrics of MRI data acquired in the course of a multicenter study.
Materials and methods: Sixty-one early stage Huntington's disease patients and forty healthy controls were studied using four different MR scanners at four European sites with acquisition protocols as close as possible to a given standard protocol. The potential and feasibility of averaging data acquired at different sites was evaluated quantitatively by region-of-interest (ROI) based statistical comparisons of coefficients of variation (CV) across centers, as well as by testing for significant group-by-center differences on averaged fractional
anisotropy (FA) values between patients and controls. In addition, a whole-brain based statistical between-group comparison was performed using FA maps.

Results: The ex post facto statistical evaluation of CV and FA-values in a priori defined ROIs showed no differences between sites above chance indicating that data were not systematically biased by center specific factors.

Conclusion: Averaging FA-maps from DTI data acquired at different study sites and different MR scanner types does not appear to be systematically biased. A suitable recipe for testing on the possibility to pool multicenter DTI data is provided to permit averaging of DTI-derived metrics to differentiate patients from healthy controls at a larger scale.
Close

Details

Original languageEnglish
Pages (from-to)161-167
Number of pages7
JournalNeuroimage: Clinical
Volume2
Early online date3 Jan 2013
DOIs
Publication statusPublished - 2013

    Research areas

  • Multicenter study, Diffusion tensor imaging, Fractional anisotropy, Huntington's disease

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. The neuropsychology of first impressions: evidence from Huntington’s disease

    Sprengelmeyer, R. H., Young, A. W., Baldas, E-M., Ratheiser, I., Sutherland, C. A. M., Müller, H-P., Grön, G., Süssmuth, S. D., Landwehrmeyer, G. B. & Orth, M., Dec 2016, In : Cortex. 85, p. 100-115 16 p.

    Research output: Contribution to journalArticle

  2. A causal role for the anterior mid-cingulate cortex in negative affect and cognitive control

    Tolomeo, S., Christmas, D., Jentzsch, I., Johnston, B., Sprengelmeyer, R., Matthews, K. & Steele, J. D., Jun 2016, In : Brain. 139, 6, p. 1844-1854 11 p.

    Research output: Contribution to journalArticle

  3. Longitudinal diffusion tensor imaging shows progressive changes in white matter in Huntington’s disease

    Gregory, S., Cole, J. H., Farmer, R. E., Rees, E. M., Roos, R. A. C., Sprengelmeyer, R. H., Duerr, A., Landwehrmeyer, B., Zhang, H., Scahill, R. I., Tabrizi, S. J., Frost, C. & Hobbs, N. Z., 2015, In : Journal of Huntington's Disease. 4, 4, p. 333-346

    Research output: Contribution to journalArticle

  4. Short-interval observational data to inform clinical trial design in early Huntington’s Disease

    Hobbs, N. Z., Farmer, R. E., Rees, E. M., Cole, J. H., Haider, S., Malone, I. B., Sprengelmeyer, R. H., Johnson, H., Mueller, H-P., Sussmuth, S. D., Roos, R. A. C., Durr, A., Frost, C., Scahill, R. I., Landwehrmeyer, B. & Tabrizi, S. J., 2015, In : Journal of Neurology, Neurosurgery, and Psychiatry.

    Research output: Contribution to journalArticle

  5. Inconsistent emotion recognition deficits across stimulus modalities in Huntington's disease

    Rees, E. M., Farmer, R., Cole, J. H., Henley, S. M. D., Sprengelmeyer, R., Frost, C., Scahill, R. I., Hobbs, N. Z. & Tabrizi, S. J., Nov 2014, In : Neuropsychologia. 64, p. 99-104 6 p.

    Research output: Contribution to journalArticle

Related by journal

  1. Evaluation of multi-modal, multi-site neuroimaging measures in Huntington's disease: Baseline results from the PADDINGTON study

    Hobbs, N. Z., Cole, J. H., Farmer, R. E., Rees, E. M., Crawford, H. E., Malone, I. B., Roos, R. A. C., Sprengelmeyer, R., Durr, A., Landwehrmeyer, B., Scahill, R. I., Tabrizi, S. J. & Frost, C., 2013, In : Neuroimage: Clinical. 2, p. 204-211 8 p.

    Research output: Contribution to journalArticle

ID: 61428302

Top