Skip to content

Research at St Andrews

Evidence for a genetic basis of urogenital carcinoma in the wild California sea lion

Research output: Contribution to journalArticle

Author(s)

Helen M. Browning, Karina Acevedo-Whitehouse, Frances M. D. Gulland, Ailsa J. Hall, Jeanie Finlayson, Mark P. Dagleish, Karen J. Billington, Kathleen Colegrove, John A. Hammond

School/Research organisations

Abstract

Although neoplasia is a major cause of mortality in humans and domestic animals, it has rarely been described in wildlife species. One of the fewexamples
is a highly prevalent urogenital carcinoma in California sea lions (CSLs).
Although the aetiology of this carcinoma is clearly multifactorial, inbreeding
depression, as estimated using levels of microsatellite multilocus heterozygosity,
is identified as predictive for this neoplasia. On further analysis, this
relationship appears to be largely driven by one marker, suggesting that a
single locus might be associated with the occurrence of this disease in CSLs.
In a case–control study, carcinoma was significantly associated with homozygosity at the Pv11 microsatellite locus. Pv11 was mapped to intron 9 of
the heparanase 2 gene (HPSE2) locus, a very large gene encoding heparanase
2, which in humans is associated with multiple carcinomas. Correspondingly,
immunohistochemical labelling in tissues was present in carcinoma cases
within a single homozygous Pv11 genotype. To our knowledge, this is the
first report of an individual locus being associated with cancer in any wildlife
species. This adds emphasis to the study of HPSE2 in other species, including
humans and will guide future studies on this sentinel species that shares much
of its diet and environment with humans

Close

Details

Original languageEnglish
Article number20140240
Number of pages10
JournalProceedings of the Royal Society B: Biological Sciences
Volume281
Issue number1796
Early online date22 Oct 2014
DOIs
Publication statusPublished - Dec 2014

    Research areas

  • Cancer, Heparanase 2 gene, Wildlife, Odds ratio

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Phylogenomic insights to the origin and spread of phocine distemper virus in European harbour seals in 1988 and 2002

    Stokholm, I., Härkönen, T., Harding, K. C., Siebert, U., Lehnert, K., Dietz, R., Teilmann, J., Galatius, A., Havmøller, L. W., Carroll, E. L., Hall, A. & Olsen, M. T., 21 Feb 2019, In : Diseases of Aquatic Organisms. 133, 1, p. 47-56 10 p.

    Research output: Contribution to journalArticle

  2. Persistent organic pollutant burden, experimental POP exposure, and tissue properties affect metabolic profiles of blubber from gray seal pups

    Robinson, K. J., Hall, A. J., Debier, C., Eppe, G., Thomé, J. P. & Bennett, K. A., 20 Nov 2018, In : Environmental Science and Technology. 52, 22, p. 13523-13534

    Research output: Contribution to journalArticle

  3. Harbor seal pup dispersal and individual morphology, hematology, and contaminant factors affecting survival

    Greig, D. J., Gulland, F. M. D., Harvey, J. T., Lonergan, M. & Hall, A. J., 31 Oct 2018, In : Marine Mammal Science. Early View, 23 p.

    Research output: Contribution to journalArticle

  4. Predicting global killer whale population collapse from PCB pollution

    Desforges, J-P., Hall, A., McConnell, B., Rosing-Asvid, A., Barber, J. L., Brownlow, A., De Guise, S., Eulaers, I., Jepson, P. D., Letcher, R. J., Levin, M., Ross, P. S., Samarra, F., Vikingson, G., Sonne, C. & Dietz, R., 28 Sep 2018, In : Science. 361, 6409, p. 1373-1376 4 p.

    Research output: Contribution to journalArticle

  5. Prevalence of urogenital carcinoma in stranded california sea lions (Zalophus californianus) from 2005–2015

    Deming, A. C., Colegrove, K. M., Duignan, P. J., Hall, A. J., Wellehan, J. F. X. & Gulland, F. M. D., 2 Mar 2018, In : Journal of Wildlife Diseases. Online First

    Research output: Contribution to journalArticle

Related by journal

  1. Proceedings of the Royal Society of London Series B: Biological Sciences (Journal)

    Oscar Eduardo Gaggiotti (Member of editorial board)
    1 Jan 2013 → …

    Activity: Publication peer-review and editorial work typesEditor of research journal

  2. Proceedings of the Royal Society B: Biological Sciences (Journal)

    Kate Arnold (Reviewer)
    2012 → …

    Activity: Publication peer-review and editorial work typesPeer review of manuscripts

  3. Proceedings of the Royal Society of London Series B: Biological Sciences (Journal)

    Michael Gordon Ritchie (Editor)
    20102011

    Activity: Publication peer-review and editorial work typesEditor of research journal

  4. Proceedings of the Royal Society B: Biological Sciences (Journal)

    Susan Denise Healy (Member of editorial board)
    2009 → …

    Activity: Publication peer-review and editorial work typesEditor of research journal

  5. Proceedings of the Royal Society B: Biological Sciences (Journal)

    Iain McCombe Matthews (Editor)
    2008 → …

    Activity: Publication peer-review and editorial work typesPeer review of manuscripts

Related by journal

  1. Advances in research on the impacts of anti-submarine sonar on beaked whales

    Bernaldo De Quirós, Y., Fernandez, A., Baird, R. W., Brownell, R. L., Aguilar De Soto, N., Allen, D., Arbelo, M., Arregui, M., Costidis, A., Fahlman, A., Frantzis, A., Gulland, F. M. D., Iñíguez, M., Johnson, M., Komnenou, A., Koopman, H., Pabst, D. A., Roe, W. D., Sierra, E., Tejedor, M. & 1 othersSchorr, G., 30 Jan 2019, In : Proceedings of the Royal Society B: Biological Sciences. 286, 1895, 20182533.

    Research output: Contribution to journalReview article

  2. Linguistic laws in chimpanzee gestural communication

    Heesen, R., Hobaiter, C., Ferrer-i-Cancho, R. & Semple, S., 13 Feb 2019, In : Proceedings of the Royal Society B: Biological Sciences. 286, 1896

    Research output: Contribution to journalArticle

  3. Northern bottlenose whales in a pristine environment respond strongly to close and distant navy sonar signals

    Wensveen, P. J., Isojunno, S., Hansen, R. R., Von Benda-beckmann, A. M., Kleivane, L., Van Ijsselmuide, S., Lam, F. A., Kvadsheim, P. H., Deruiter, S. L., Curé, C., Narazaki, T., Tyack, P. L. & Miller, P. J. O., 20 Mar 2019, In : Proceedings of the Royal Society B: Biological Sciences. 286, 1899, 10 p., 20182592.

    Research output: Contribution to journalArticle

  4. Release from intralocus sexual conflict? Evolved loss of a male sexual trait demasculinizes female gene expression

    Rayner, J., Pascoal, S. C. M. & Bailey, N. W., 17 Apr 2019, In : Proceedings of the Royal Society B: Biological Sciences. 286, 1901, 8 p., 20190497.

    Research output: Contribution to journalArticle

  5. The decision to move: response times, neuronal circuits and sensory memory in a simple vertebrate

    Roberts, A., Borisyuk, R., Buhl, E., Ferrario, A., Koutsikou, S., Li, W-C. & Soffe, S. R., Mar 2019, In : Proceedings of the Royal Society B: Biological Sciences. 286, 1899, 7 p., 20190297.

    Research output: Contribution to journalReview article

ID: 155895591