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Evolution of MRSA During Hospital Transmission and Intercontinental Spread

Research output: Contribution to journalArticle

DOI

Author(s)

Simon R. Harris, Edward J. Feil, Matthew Thomas Geoffrey Holden, Michael A. Quail, Emma K. Nickerson, Narisara Chantratita, Susana Gardete, Ana Tavares, Nick Day, Jodi A. Lindsay, Jonathan D. Edgeworth, Herminia de Lencastre, Julian Parkhill, Sharon J. Peacock, Stephen D. Bentley

School/Research organisations

Abstract

Current methods for differentiating isolates of predominant lineages of pathogenic bacteria often do not provide sufficient resolution to define precise relationships. Here, we describe a high-throughput genomics approach that provides a high-resolution view of the epidemiology and microevolution of a dominant strain of methicillin-resistant Staphylococcus aureus (MRSA). This approach reveals the global geographic structure within the lineage, its intercontinental transmission through four decades, and the potential to trace person-to-person transmission within a hospital environment. The ability to interrogate and resolve bacterial populations is applicable to a range of infectious diseases, as well as microbial ecology.

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Original languageEnglish
Pages (from-to)469-474
Number of pages6
JournalScience
Volume327
Issue number5964
DOIs
Publication statusPublished - 22 Jan 2010

    Research areas

  • RESISTANT STAPHYLOCOCCUS-AUREUS, IDENTIFICATION, CLONES, TRIMETHOPRIM, MUTATION, STRAIN

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ID: 74262431