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Exacerbation of the credit assignment problem in rats with lesions of the medial prefrontal cortex is revealed by Bayesian analysis of behavior in the pre-solution period of learning

Research output: Contribution to journalArticlepeer-review

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Exacerbation of the credit assignment problem in rats with lesions of the medial prefrontal cortex is revealed by Bayesian analysis of behavior in the pre-solution period of learning. / Wang, Jiachao; Tait, David S.; Brown, Verity J.; Bowman, Eric M.

In: Behavioural Brain Research, Vol. 372, 112037, 17.10.2019.

Research output: Contribution to journalArticlepeer-review

Harvard

Wang, J, Tait, DS, Brown, VJ & Bowman, EM 2019, 'Exacerbation of the credit assignment problem in rats with lesions of the medial prefrontal cortex is revealed by Bayesian analysis of behavior in the pre-solution period of learning', Behavioural Brain Research, vol. 372, 112037. https://doi.org/10.1016/j.bbr.2019.112037

APA

Wang, J., Tait, D. S., Brown, V. J., & Bowman, E. M. (2019). Exacerbation of the credit assignment problem in rats with lesions of the medial prefrontal cortex is revealed by Bayesian analysis of behavior in the pre-solution period of learning. Behavioural Brain Research, 372, [112037]. https://doi.org/10.1016/j.bbr.2019.112037

Vancouver

Wang J, Tait DS, Brown VJ, Bowman EM. Exacerbation of the credit assignment problem in rats with lesions of the medial prefrontal cortex is revealed by Bayesian analysis of behavior in the pre-solution period of learning. Behavioural Brain Research. 2019 Oct 17;372. 112037. https://doi.org/10.1016/j.bbr.2019.112037

Author

Wang, Jiachao ; Tait, David S. ; Brown, Verity J. ; Bowman, Eric M. / Exacerbation of the credit assignment problem in rats with lesions of the medial prefrontal cortex is revealed by Bayesian analysis of behavior in the pre-solution period of learning. In: Behavioural Brain Research. 2019 ; Vol. 372.

Bibtex - Download

@article{7b48efb508124e4f9f1f97bef77aa79b,
title = "Exacerbation of the credit assignment problem in rats with lesions of the medial prefrontal cortex is revealed by Bayesian analysis of behavior in the pre-solution period of learning",
abstract = "Our internal models of the world help us to process information rapidly: in general model-based learning is more rapid than model-free learning. However, the cognitive flexibility required to overcome cognitive predispositions can let us down: it is not fully developed until adulthood; predispositions can be unconscious biases; and cognitive flexibility is impaired in many psychiatric and neurological conditions. To understand these limits to flexibility, we need to know how brain generates predispositions and deploys flexibility.We performed a detailed analysis of the exploratory behavior of rats in the pre-solution period of a two-alternative forced choice discrimination learning task. Rats readily learn in which of two bowls, filled with differentially scented and textured digging materials, there is hidden bait. In a single session, they are presented with a series of discrimination learning and reversal stages. We performed a simple Bayesian analysis on the data from 68 rats, 33 of which had lesions of the medial prefrontal cortex), to examine patterns of responding in the pre-solution period.Control rats rapidly focussed on the relevant stimulus attributes and showed flexibility when required to learn about a different stimulus attribute. Rats with prefrontal cortex damage had reduced sensitivity to negative feedback. They were able to overcome this deficit and solve the credit assignment problem when there were limited alternatives or when attention was appropriately focused and predispositions matched the required response. However, the learning impairment presents as a problem with shifting attention due to the additional difficulty of solving the credit assignment problem when the attentional set is inconsistent with the required response.",
keywords = "Prefrontal cortex, Set-shifting, Executive function, Bayes, Learning",
author = "Jiachao Wang and Tait, {David S.} and Brown, {Verity J.} and Bowman, {Eric M.}",
note = "Funding: JW received a PhD scholarship from the University of St Andrews.",
year = "2019",
month = oct,
day = "17",
doi = "10.1016/j.bbr.2019.112037",
language = "English",
volume = "372",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Exacerbation of the credit assignment problem in rats with lesions of the medial prefrontal cortex is revealed by Bayesian analysis of behavior in the pre-solution period of learning

AU - Wang, Jiachao

AU - Tait, David S.

AU - Brown, Verity J.

AU - Bowman, Eric M.

N1 - Funding: JW received a PhD scholarship from the University of St Andrews.

PY - 2019/10/17

Y1 - 2019/10/17

N2 - Our internal models of the world help us to process information rapidly: in general model-based learning is more rapid than model-free learning. However, the cognitive flexibility required to overcome cognitive predispositions can let us down: it is not fully developed until adulthood; predispositions can be unconscious biases; and cognitive flexibility is impaired in many psychiatric and neurological conditions. To understand these limits to flexibility, we need to know how brain generates predispositions and deploys flexibility.We performed a detailed analysis of the exploratory behavior of rats in the pre-solution period of a two-alternative forced choice discrimination learning task. Rats readily learn in which of two bowls, filled with differentially scented and textured digging materials, there is hidden bait. In a single session, they are presented with a series of discrimination learning and reversal stages. We performed a simple Bayesian analysis on the data from 68 rats, 33 of which had lesions of the medial prefrontal cortex), to examine patterns of responding in the pre-solution period.Control rats rapidly focussed on the relevant stimulus attributes and showed flexibility when required to learn about a different stimulus attribute. Rats with prefrontal cortex damage had reduced sensitivity to negative feedback. They were able to overcome this deficit and solve the credit assignment problem when there were limited alternatives or when attention was appropriately focused and predispositions matched the required response. However, the learning impairment presents as a problem with shifting attention due to the additional difficulty of solving the credit assignment problem when the attentional set is inconsistent with the required response.

AB - Our internal models of the world help us to process information rapidly: in general model-based learning is more rapid than model-free learning. However, the cognitive flexibility required to overcome cognitive predispositions can let us down: it is not fully developed until adulthood; predispositions can be unconscious biases; and cognitive flexibility is impaired in many psychiatric and neurological conditions. To understand these limits to flexibility, we need to know how brain generates predispositions and deploys flexibility.We performed a detailed analysis of the exploratory behavior of rats in the pre-solution period of a two-alternative forced choice discrimination learning task. Rats readily learn in which of two bowls, filled with differentially scented and textured digging materials, there is hidden bait. In a single session, they are presented with a series of discrimination learning and reversal stages. We performed a simple Bayesian analysis on the data from 68 rats, 33 of which had lesions of the medial prefrontal cortex), to examine patterns of responding in the pre-solution period.Control rats rapidly focussed on the relevant stimulus attributes and showed flexibility when required to learn about a different stimulus attribute. Rats with prefrontal cortex damage had reduced sensitivity to negative feedback. They were able to overcome this deficit and solve the credit assignment problem when there were limited alternatives or when attention was appropriately focused and predispositions matched the required response. However, the learning impairment presents as a problem with shifting attention due to the additional difficulty of solving the credit assignment problem when the attentional set is inconsistent with the required response.

KW - Prefrontal cortex

KW - Set-shifting

KW - Executive function

KW - Bayes

KW - Learning

U2 - 10.1016/j.bbr.2019.112037

DO - 10.1016/j.bbr.2019.112037

M3 - Article

C2 - 31202862

VL - 372

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

M1 - 112037

ER -

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