Skip to content

Research at St Andrews

Exploring the emergence of complexity using synthetic replicators

Research output: Contribution to journalArticle

DOI

Open Access permissions

Open

Author(s)

Tamara Kosikova, Douglas Philp

School/Research organisations

Abstract

A significant number of synthetic systems capable of replicating themselves or entities that are complementary to themselves have appeared in the last 30 years. Building on an understanding of the operation of synthetic replicators in isolation, this field has progressed to examples where catalytic relationships between replicators within the same network and the extant reaction conditions play a role in driving phenomena at the level of the whole system. Systems chemistry has played a pivotal role in the attempts to understand the origin of biological complexity by exploiting the power of synthetic chemistry, in conjunction with the molecular recognition toolkit pioneered by the field of supramolecular chemistry, thereby permitting the bottom-up engineering of increasingly complex reaction networks from simple building blocks. This review describes the advances facilitated by the systems chemistry approach in relating the expression of complex and emergent behaviour in networks of replicators with the connectivity and catalytic relationships inherent within them. These systems, examined within well-stirred batch reactors, represent conceptual and practical frameworks that can then be translated to conditions that permit replicating systems to overcome the fundamental limits imposed on selection processes in networks operating under closed conditions. This shift away from traditional spatially homogeneous reactors towards dynamic and non-equilibrium conditions, such as those provided by reaction-diffusion reaction formats, constitutes a key change that mimics environments within cellular systems, which possess obvious compartmentalisation and inhomogeneity.
Close

Details

Original languageEnglish
Pages (from-to)7274-7305
JournalChemical Society Reviews
Volume46
Issue number23
Early online date3 Nov 2017
DOIs
Publication statusPublished - 7 Dec 2017

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Compositional persistence in a multicyclic network of synthetic replicators

    Huck, J., Kosikova, T. & Philp, D., 4 Sep 2019, In : Journal of the American Chemical Society. 141, 35, p. 13905-13913

    Research output: Contribution to journalArticle

  2. Two synthetic replicators compete to process a dynamic reagent pool

    Kosikova, T. & Philp, D., 20 Feb 2019, In : Journal of the American Chemical Society. 141, 7, p. 3059-3072

    Research output: Contribution to journalArticle

  3. An environmentally-responsive reciprocal replicating network

    Robertson, C. C., Mackenzie, H. W., Kosikova, T. & Philp, D., 6 Jun 2018, In : Journal of the American Chemical Society. 140, 22, p. 6832-6841 10 p.

    Research output: Contribution to journalArticle

  4. Generating system-level responses from a network of simple synthetic replicators

    Sadownik, J. W., Kosikova, T. & Philp, D., 6 Dec 2017, In : Journal of the American Chemical Society. 139, 48, p. 17565-17573

    Research output: Contribution to journalArticle

  5. A critical cross-catalytic relationship determines the outcome of competition in a replicator network

    Kosikova, T. & Philp, D., 4 Aug 2017, In : Journal of the American Chemical Society. 139, 36, p. 12579-12590

    Research output: Contribution to journalArticle

Related by journal

  1. Advances in the synthesis of nitroxide radicals for use in biomolecule spin labelling

    Haugland, M., Lovett, J. E. & Anderson, E., 7 Feb 2018, In : Chemical Society Reviews. 47, 3, p. 668-680

    Research output: Contribution to journalReview article

  2. Challenges in developing direct carbon fuel cells

    Jiang, C., Ma, J., Corre, G., Jain, S. L. & Irvine, J. T. S., 21 May 2017, In : Chemical Society Reviews. 46, 10, p. 2889-2912 24 p.

    Research output: Contribution to journalReview article

  3. Coordination change, lability and hemilability in metal-organic frameworks

    Morris, R. E. & Brammer, L., 7 Sep 2017, In : Chemical Society Reviews. 46, 17, p. 5444-5462 19 p.

    Research output: Contribution to journalReview article

  4. Inorganic perovskite photocatalysts for solar energy utilization

    Zhang, G., Liu, G., Wang, L. & Irvine, J. T. S., 7 Nov 2016, In : Chemical Society Reviews. 45, 21, p. 5951-5984 34 p.

    Research output: Contribution to journalReview article

ID: 251504421

Top