Skip to content

Research at St Andrews

Factors associated with recruitment to randomised controlled trials in general practice: protocol for a systematic review

Research output: Contribution to journalArticlepeer-review

Abstract


Background: Randomised controlled trials (RCTs) are frequently unable to recruit sufficient numbers of participants. This affects the trial’s ability to answer the proposed research question, wastes resources and can be unethical. RCTs within a general practice setting are increasingly common and similarly face recruitment challenges. The aim of the proposed review is to identify factors that are associated with recruitment rates to RCTs in a general practice setting. These results will be used in further research to predict recruitment to RCTs.

Methods/design: The electronic databases Medline, EMBASE, Cochrane Database of Systematic Reviews, NTIS and OpenGrey will be searched for relevant articles with no limit on the date of publication. BMC Trials will be manually searched for the past 5 years. Both quantitative and qualitative studies will be included if they have studied recruitment within a general practice RCT. Only English language publications will be included. Screening, quality assessment and data extraction will be conducted by two review authors not blinded to study characteristics. Disagreement will be resolved by discussion and the involvement of a third review author if required. A narrative synthesis of the studies included will be performed.

Discussion: The review will, for the first time, systematically synthesise existing research on factors associated with recruitment rates to RCTs in general practice. By identifying research gaps to be prioritised in further research, it will be of interest to academics. It will also be of value to clinical trialists who are involved in the complex task of improving trial recruitment. Our team will use the findings to inform a prediction model of trial recruitment using machine learning.
Close

Details

Original languageEnglish
Article number66
Number of pages4
JournalTrials
Volume20
DOIs
Publication statusPublished - 10 May 2019

    Research areas

  • Recruitment, General practice, Randomised controlled trial

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Over-use of thyroid testing in Canadian and UK primary care in frequent attenders: a cross-sectional study

    Crampton, N., Kalia, S., Del Giudice, M. E., Wintemute, K., Sullivan, F., Aliarzadeh, B., Meaney, C., Moineddin, R., Singer, A., Hinton, W., Sherlock, J., Williams, J., de Lusignan, S. & Greiver, M., 28 Mar 2021, In: International Journal of Clinical Practice. Early Vew, e14144.

    Research output: Contribution to journalArticlepeer-review

  2. Trends in diabetes medication use in Australia, Canada, England, and Scotland: A repeated cross-sectional analysis in primary care

    Greiver, M., Havard, A., Bowles, J. K. F., Kalia, S., Chen, T., Aliarzadeh, B., Moineddin, R., Sherlock, J., Hinton, W., Sullivan, F., O'Neill, B., Pow, C., Bhatt, A., Rahman, F., Meza-Torres, B., Litchfield, M. & de Lusignan, S., Mar 2021, In: British Journal of General Practice. 71, 704, p. E209-E218

    Research output: Contribution to journalArticlepeer-review

  3. Trends in diabetes medication use in Canada, England, Scotland and Australia: a repeated cross-sectional analysis (2012-2017)

    Greiver, M., Havard, A., Kuster Filipe Bowles, J., Kalia, S., Chen, T., Aliarzadeh, B., Moineddin, R., Sherlock, J., Hinton, W., Sullivan, F., O'Neill, B., Pow, C., Bhatt, A., Rahman, F., Meza-Torres, B., Litchfield, M. & de Lusignan, S., Mar 2021, In: British Journal of General Practice. 71, 704, p. e209-e218

    Research output: Contribution to journalArticlepeer-review

  4. Earlier diagnosis of lung cancer in a randomised trial of an autoantibody blood test followed by imaging

    Sullivan, F. M., Mair, F. S., Anderson, W., Armory, P., Briggs, A., Chew, C., Dorward, A., Haughney, J., Hogarth, F., Kendrick, D., Littleford, R., Mcconnachie, A., McCowan, C., Mcmeekin, N., Patel, M., Rauchhaus, P., Ritchie, L., Robertson, C., Robertson, J., Robles-Zurita, J. & 8 others, Sarvesvaran, J., Sewell, H., Sproule, M., Taylor, T., Tello, A., Treweek, S., Vedhara, K. & Schembri, S., 1 Jan 2021, In: European Respiratory Journal. 57, 1, 11 p., 2000670.

    Research output: Contribution to journalArticlepeer-review

Related by journal

  1. Pharmacokinetics, SAfety/tolerability, and EFficacy of high-dose RIFampicin in tuberculosis-HIV co-infected patients on efavirenz- or dolutegravir-based antiretroviral therapy: study protocol for an open-label phase II clinical trial (SAEFRIF)

    Nabisere, R., Musaazi, J., Denti, P., Aber, F., Lamorde, M., Dooley, K. E., Aarnoutse, R., Sloan, D. J. & Sekaggya-Wiltshire, C., 13 Feb 2020, In: Trials. 21, 9 p., 181.

    Research output: Contribution to journalArticlepeer-review

  2. Trial Forge Guidance 2: how to decide if a further Study Within A Trial (SWAT) is needed

    Treweek, S., Bevan, S., Bower, P., Briel, M., Campbell, M., Christie, J., Collett, C., Cotton, S., Devane, D., El Feky, A., Galvin, S., Gardner, H., Gillies, K., Hood, K., Jansen, J., Littleford, R., Parker, A., Ramsay, C., Restrup, L., Sullivan, F. & 7 others, Torgerson, D., Tremain, L., von Elm, E., Westmore, M., Williams, H., Williamson, P. R. & Clarke, M., 7 Jan 2020, In: Trials. 21, 9 p., 33.

    Research output: Contribution to journalArticlepeer-review

  3. The effect of optimised patient information materials on recruitment in a lung cancer screening trial: an embedded randomised recruitment trial

    Parker, A., Knapp, P., Treweek, S., Madhurasinghe, V., Littleford, R., Gallant, S., Sullivan, F., Schembri, S., Rick, J., Graffy, J., Collier, D. J., Eldridge, S., Kennedy, A. & Bower, P., 18 Sep 2018, In: Trials. 19

    Research output: Contribution to journalArticlepeer-review

  4. Trial Forge Guidance 1: what is a Study Within A Trial (SWAT)?

    Treweek, S., Bevan, S., Bower, P., Campbell, M., Christie, J., Clarke, M., Collett, C., Cotton, S., Devane, D., El Feky, A., Flemyng, E., Galvin, S., Gardner, H., Gillies, K., Jansen, J., Littleford, R., Parker, A., Ramsay, C., Restrup, L., Sullivan, F. & 4 others, Torgerson, D., Tremain, L., Westmore, M. & Williamson, P. R., 23 Feb 2018, In: Trials. 19, 5 p., 139.

    Research output: Contribution to journalArticlepeer-review

ID: 258447481

Top