Skip to content

Research at St Andrews

Fast silencing reveals a lost role for reciprocal inhibition in locomotion

Research output: Contribution to journalArticle

Abstract

Summary Alternating contractions of antagonistic muscle groups during locomotion are generated by spinal “half-center” networks coupled in antiphase by reciprocal inhibition. It is widely thought that reciprocal inhibition only coordinates the activity of these muscles. We have devised two methods to rapidly and selectively silence neurons on just one side of Xenopus tadpole spinal cord and hindbrain, which generate swimming rhythms. Silencing activity on one side led to rapid cessation of activity on the other side. Analyses reveal that this resulted from the depression of reciprocal inhibition connecting the two sides. Although critical neurons in intact tadpoles are capable of pacemaker firing individually, an effect that could support motor rhythms without inhibition, the swimming network itself requires ∼23 min to regain rhythmic activity after blocking inhibition pharmacologically, implying some homeostatic changes. We conclude therefore that reciprocal inhibition is critical for the generation of normal locomotor rhythm.
Close

Details

Original languageEnglish
Pages (from-to)129-140
Number of pages12
JournalNeuron
Volume77
Issue number1
DOIs
Publication statusPublished - 9 Jan 2013

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. The neuronal mechanisms underlying locomotion termination

    Ritson, E. J. & Li, W-C., Apr 2019, In : Current Opinion in Physiology. 8, p. 109-115 7 p.

    Research output: Contribution to journalReview article

  2. The decision to move: response times, neuronal circuits and sensory memory in a simple vertebrate

    Roberts, A., Borisyuk, R., Buhl, E., Ferrario, A., Koutsikou, S., Li, W-C. & Soffe, S. R., Mar 2019, In : Proceedings of the Royal Society B: Biological Sciences. 286, 1899, 7 p., 20190297.

    Research output: Contribution to journalReview article

  3. A simple decision to move in response to touch reveals basic sensory memory and mechanisms for variable response times

    Koutsikou, S., Merrison-Hort, R., Buhl, E., Ferrario, A., Li, W-C., Borisyuk, R., Soffe, S. R. & Roberts, A., 19 Sep 2018, In : The Journal of Physiology. In press

    Research output: Contribution to journalArticle

  4. Bifurcations of limit cycles in a reduced model of the Xenopus tadpole central pattern generator

    Ferrario, A., Merrison-Hort, R., Soffe, S. R., Li, W-C. & Borisyuk, R., 18 Jul 2018, In : Journal of Mathematical Neuroscience. 8, 1, 31 p., 10.

    Research output: Contribution to journalArticle

Related by journal

  1. An open resource for non-human primate imaging

    Milham, M. P., Ai, L., Koo, B., Xu, T., Amiez, C., Balezeau, F., Baxter, M. G., Blezer, E. L. A., Brochier, T., Chen, A., Croxson, P. L., Damatac, C. G., Dehaene, S., Everling, S., Fair, D. A., Fleysher, L., Freiwald, W., Froudist-Walsh, S., Griffiths, T. D., Guedj, C. & 50 others, Hadj-Bouziane, F., Ben Hamed, S., Harel, N., Hiba, B., Jarraya, B., Jung, B., Kastner, S., Klink, P. C., Kwok, S. C., Laland, K. N., Leopold, D. A., Lindenfors, P., Mars, R. B., Menon, R. S., Messinger, A., Meunier, M., Mok, K., Morrison, J. H., Nacef, J., Nagy, J., Rios, M. O., Petkov, C. I., Pinsk, M., Poirier, C., Procyk, E., Rajimehr, R., Reader, S. M., Roelfsema, P. R., Rudko, D. A., Rushworth, M. F. S., Russ, B. E., Sallet, J., Schmid, M. C., Schwiedrzik, C. M., Seidlitz, J., Sein, J., Shmuel, A., Sullivan, E. L., Ungerleider, L., Thiele, A., Todorov, O. S., Tsao, D., Wang, Z., Wilson, C. R. E., Yacoub, E., Ye, F. Q., Zarco, W., Zhou, Y., Margulies, D. S. & Schroeder, C. E., 10 Oct 2018, In : Neuron. 100, 1, p. 61-74 e2.

    Research output: Contribution to journalArticle

  2. Selective inhibition mediates the sequential recruitment of motor pools

    Zwart, M. F., Pulver, S. R., Truman, J. W., Fushiki, A., Fetter, R. D., Cardona, A. & Landgraf, M., 3 Aug 2016, In : Neuron. 91, 3, p. 615-628 14 p.

    Research output: Contribution to journalArticle

  3. Selective inhibition mediates the sequential recruitment of motor pools: Correction

    Zwart, M. F., Pulver, S., Truman, J., Fushiki, A., Cardona, A. & Landgraf, M., 17 Aug 2016, In : Neuron. 91, 4, p. 944

    Research output: Contribution to journalArticle

  4. Even-skipped+ interneurons are core components of a sensorimotor circuit that maintains left-right symmetric muscle contraction amplitude

    Heckscher, E., Zarin, A., Faumont, S., Clark, M., Manning, L., Fushiki, A., Schneider-Mizell, C., Fetter, R. D., Truman, J., Zwart, M. F., Landgraf, M., Cardona, A., Lockery, S. & Doe, C., 21 Oct 2015, In : Neuron. 88, 2, p. 314-329

    Research output: Contribution to journalArticle

ID: 42943976

Top