Skip to content

Research at St Andrews

Fibroblasts in head neck squamous cell carcinoma associated with perineural invasion have high level nuclear Yes-Associated Protein (YAP) expression

Research output: Contribution to journalArticle

Author(s)

Yanghua Wang, Adam Gersten, Susana Moleirinho, Frank Gunn-Moore, Paul Andrew Reynolds, Michael Prystowsky

School/Research organisations

Abstract

We retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma with associated perineural invasion. We find that fibroblasts in areas associated with perineural invasion show higher levels of nuclear YAP compared to fibroblasts in the stroma of normal mucosa, with a median cell count of 35.4 per high-power field in the former and 3.9 in the latter. No differences were observed between the expression of YAP phosphorylated at Ser127 in the tumoral stroma compared to that in the normal mucosa, with a median cell count expression of 4.9 in the former versus 5.0 in the latter. Therefore, a strong and increased nuclear YAP expression in fibroblasts associated with perineural invasion in head and neck squamous cell carcinoma suggests that YAP-mediated transcription programs in these fibroblasts may contribute to perineural invasion.
Close

Details

Original languageEnglish
Number of pages5
JournalAcademic Pathology
Volume2
Issue number4
Early online date26 Nov 2015
DOIs
Publication statusPublished - Dec 2015

    Research areas

  • Squamous cell carcinoma, perineural invasion, YAP expression, fibroblast

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells

    Tilston-Lunel, A. M., Haley, K., Schlecht, N., Wang, Y., Chatterton, A. L. D., Moleirinho, S. L., Watson, A., Hundal, H., Prystowsky, M., Gunn-Moore, F. J. & Reynolds, P. A., Oct 2016, In : Journal of Molecular Cell Biology. 8, 5, p. 439-455

    Research output: Contribution to journalArticle

  2. Willing to be involved in cancer

    Gunn-Moore, F. J., Tilston-Lunel, A. M. & Reynolds, P. A., 18 Jul 2016, In : Genes. 7, 7, 13 p., 37.

    Research output: Contribution to journalReview article

  3. Willin, an upstream component of the Hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts

    Moleirinho, S., Patrick, C., Tilston-Lunel, A. M., Higginson, JR., Angus, L., Antkowiak, M., Barnett, S., Prystowsky, M., Reynolds, P. A. & Gunn-Moore, F. J., 8 Apr 2013, In : PLoS ONE. 8, 4, 15 p., e60028.

    Research output: Contribution to journalArticle

  4. KIBRA Exhibits MST-independent Functional Regulation of the Hippo Signaling Pathway in Mammals

    Moleirinho, S., Chang, N., Sims, A., Tilston-Lunel, A. M., Angus, L., Steele, A., Boswell, V., Barnett, S., Ormandy, C., Faratian, D., Gunn-Moore, F. J. & Reynolds, P. A., 2013, In : Oncogene. 32, 14, p. 1821-1830 10 p.

    Research output: Contribution to journalArticle

  5. The Expanding Family of FERM Proteins.

    Moleirinho, S., Tilston-Lunel, A. M., Angus, L., Gunn-Moore, F. J. & Reynolds, P. A., 2013, In : Biochemical Journal. 452 , 2, p. 183-193

    Research output: Contribution to journalArticle

ID: 226915841

Top