Skip to content

Research at St Andrews

Fin development in a cartilaginous fish and the origin of vertebrate limbs

Research output: Contribution to journalArticle

DOI

Author(s)

M Tanaka, A Munsterberg, W G Anderson, A R Prescott, N Hazon, C Tickle

School/Research organisations

Abstract

Recent fossil finds and experimental analysis of chick and mouse embryos highlighted the lateral fin fold theory, which suggests that two pairs of limbs in tetrapods evolved by subdivision of an elongated single fin(1). Here we examine fin development in embryos of the primitive cartilaginous fish, Scyliorhinus canicula (dogfish) using scanning electron microscopy and investigate expression of genes known to be involved in limb positioning, identity and patterning in higher vertebrates. Although we did not detect lateral fin folds in dogfish embryos, Engrailed-1 expression suggests that the body is compartmentalized dorsoventrally. Furthermore, specification of limb identity occurs through the Tbx4 and Tbx5 genes, as in higher vertebrates. In contrast, unlike higher vertebrates, we did not detect Shh transcripts in dogfish fin-buds, although dHand (a gene involved in establishing Shh) is expressed. In S. canicula, the main fin axis seems to lie parallel to the body axis. 'Freeing' fins from the body axis and establishing a separate 'limb' axis has been proposed to be a crucial step in evolution of tetrapod limbs(2,3). We suggest that Shh plays a critical role in this process.

Close

Details

Original languageEnglish
Pages (from-to)527-531
Number of pages5
JournalNature
Volume416
Issue number6880
DOIs
Publication statusPublished - 4 Apr 2002

    Research areas

  • APICAL ECTODERMAL RIDGE, POLARIZING ACTIVITY, SONIC-HEDGEHOG, CHICK-EMBRYOS, HOX GENES, EVOLUTION

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Individual size, sex and rearing environment impact on aggression in newly weaned seals

    Robinson, K. J., Pomeroy, P. P., Hazon, N., Moss, S. & Twiss, S. D., Apr 2017, In : Marine Mammal Science. 33, 2, p. 621-629 9 p.

    Research output: Contribution to journalArticle

  2. Maternal oxytocin is linked to close mother-infant proximity in grey seals (Halichoerus grypus)

    Robinson, K. J., Twiss, S. D., Hazon, N. & Pomeroy, P., 23 Dec 2015, In : PLoS One. 10, 12, 17 p., e0144577.

    Research output: Contribution to journalArticle

  3. Conspecific recognition and aggression reduction to familiars in newly weaned, socially plastic mammals

    Robinson, K. J., Twiss, S., Hazon, N., Moss, S., Lonergan, M. & Pomeroy, P., Aug 2015, In : Behavioral Ecology and Sociobiology. 69, 8, p. 1383-1394 12 p.

    Research output: Contribution to journalArticle

Related by journal

  1. Amphioxus functional genomics and the origins of vertebrate gene regulation

    Marletaz, F., Firbas, P., Maeso, I., Tena, J., Bogdanovic, O., Perry, M., Wyatt, C., de la Calle-Mustienes, E., Bertrand, S., Burguera, D., Acemel, R., van Heeringen, S., Naranjo, S., Herrera-Ubeda, C., Skvortsova, K., Jimenez-Gancedo, S., Aldea, D., Marquez, Y., Buono, L., Kozmikova, I. & 41 othersPermanyer, J., Louis, A., Albuixech-Crespo, B., Le Petillon, Y., Leon Florian, A., Subirana, L., Balwierz, P. J., Duckett, P., Farahani, E., Aury, J. M., Mangenot, S., Wincker, P., Albalat, R., Benito-Gutierrez, E., Canestro, C., Castro, F., D'Aniello, S., Ferrier, D. E. K., Huang, S., Laudet, V., Marais, G., Pontarotti, P., Schubert, M., Seitz, H., Somorjai, I. M. L., Takahashi, T., Mirabeau, O., Xu, A., Yu, J-K., Carninci, P., Martinez-Morales, J., Crollius, H., Kozmik, Z., Weirauch, M., Garcia-Fernandez, J., Lister, R., Lenhard, B., Holland, P., Escriva, H., Gomez-Skarmeta, J. L. & Irimia, M., 21 Nov 2018, In : Nature. 564, 7734, p. 64-70 29 p.

    Research output: Contribution to journalArticle

  2. An absolute sodium abundance for a cloud-free 'hot Saturn' exoplanet

    Nikolov, N., Sing, D. K., Fortney, J. J., Goyal, J. M., Drummond, B., Evans, T. M., Gibson, N. P., De Mooj, E. J. W., Rustamkulov, Z., Wakeford, H. R., Smalley, B., Burgasser, A. J., Hellier, C., Helling, C., Mayne, N. J., Madhusudhan, N., Kataria, T., Baines, J., Carter, A. L., Ballester, G. E. & 3 othersBarstow, J. K., McCleery, J. & Spake, J. J., 7 May 2018, In : Nature. 557, p. 526-529

    Research output: Contribution to journalArticle

  3. CO2 storage and release in the deep Southern Ocean on millennial to centennial timescales

    Rae, J. W. B., Burke, A., Robinson, L. F., Adkins, J. F., Chen, T., Cole, C., Greenop, R., Li, T., Littley, E., Nita, D. C., Stewart, J. A. & Taylor, B., 24 Oct 2018, In : Nature. 562, p. 569-573 16 p.

    Research output: Contribution to journalLetter

  4. Does the galaxy NGC1052-DF2 falsify Milgromian dynamics?

    Kroupa, P., Haghi, H., Javanmardi, B., Zonoozi, A. H., Müller, O., Banik, I., Wu, X., Zhao, H. & Dabringhausen, J., 12 Sep 2018, In : Nature. 561, p. E4-E5 2 p.

    Research output: Contribution to journalComment/debate

  5. Exciton-polariton topological insulator

    Klembt, S., Harder, T. H., Egorov, O. A., Winkler, K., Ge, R., Bandres, M. A., Emmerling, M., Worschech, L., Liew, T. C. H., Segev, M., Schneider, C. & Höfling, S., 8 Oct 2018, In : Nature. 16 p.

    Research output: Contribution to journalArticle

Related by journal

  1. Nature (Journal)

    Will Cresswell (Reviewer)
    21 Dec 2017

    Activity: Publication peer-review and editorial work typesPeer review of manuscripts

  2. Nature (Journal)

    Will Cresswell (Reviewer)
    11 Nov 2017

    Activity: Publication peer-review and editorial work typesPeer review of manuscripts

  3. Nature (Journal)

    David Gerard Dritschel (Editor)
    2005 → …

    Activity: Publication peer-review and editorial work typesEditor of research journal

  4. Nature (Journal)

    Ifor David William Samuel (Editor)
    2005 → …

    Activity: Publication peer-review and editorial work typesEditor of research journal

ID: 780706