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Research at St Andrews

Fluorescence detection of superficial skin cancers

Research output: Contribution to journalArticle

Author(s)

J Hewett, T McKechnie, W Sibbett

School/Research organisations

Abstract

We present a simple fluorescent diagnosis system for the demarcation of skin cancers. 5-aminolaevulinic acid (ALA) cream is applied to the suspicious area resulting in the accumulation of the photosensitizer Protoporphyrin IX (PpIX) in the cancerous tissue. When excited at 400 nm using a filtered mercury arc lamp, the PpIX fluoresces at 635 nm. Our imaging system acquires four spectrally specific images at 635, 540, 470 and 400 nm for the PpIX fluorescence, natural skin autofluorescence and illumination respectively. Subsequent image processing combines these images into a single display showing clearly the localization and extent of the tumour.

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Details

Original languageEnglish
Pages (from-to)2021-2027
Number of pages7
JournalJournal of Modern Optics
Volume47
Publication statusPublished - Sep 2000

    Research areas

  • SPECTROSCOPY, TUMORS

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