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Fluorine containing cyclopropanes: synthesis of aryl substituted all-cis 1,2,3-trifluorocylopropanes, a facially polar motif

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Abstract

The synthesis of substituted all-cis-1,2,3-trifluorocylopropanes are described for the first time. The three fluorines located on each of the cyclopropyl carbons with a stereochemistry where they are all on the same face of the cyclopropane, imparts a significant polarity to the molecule, and the inherent conformational rigidity and lowering of Log P makes this motif attractive for exploration as a substituent for pharmaceuticals and agrochemicals research.
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Original languageEnglish
Pages (from-to)10539-10542
JournalChemical Communications
Volume55
Issue number71
Early online date9 Aug 2019
DOIs
Publication statusPublished - 14 Sep 2019

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