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Formal synthesis of (+)-lactacystin from L-serine

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Author(s)

Philip C. Bulman Page, Ross L. Goodyear, Yohan Chan, Alexandra M. Z. Slawin, Steven M. Allin

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Abstract

A formal, stereocontrolled synthesis of lactacystin has been completed from t-Bu-O-L-serine, providing the key intermediate 13, also useful for the generation of a range of C-9 analogues.

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Original languageEnglish
Pages (from-to)30019-30032
Number of pages14
JournalRSC Advances
Volume9
Issue number51
Early online date24 Sep 2019
DOIs
Publication statusE-pub ahead of print - 24 Sep 2019

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