Skip to content

Research at St Andrews

Further proctolin analogues modified in the position 2 of the peptide chain and their myotropic effects in insects Tenebrio molitor and Schistocerca gregaria

Research output: Contribution to journalArticle

Author(s)

Mariola Kuczer, Grzegorz Rosiński, Jonathan Issberner, Richard Osborne, Danuta Konopińska

School/Research organisations

Abstract

We have extended our studies on the structure-activity relationship in neuropeptide proctolin (Arg-Tyr-Leu-Pro-Thr) by evaluating the effects of a series of proctolin analogues modified in position 2 of the peptide chain, including: [Phe(p-Cl)2]-(1), [D-Phe(p-Cl)2]-(2), [N-Me-Tyr2]-(3), [D-Phe(p-NH2)2]-(4), [D-Phe(p-N,N-di-Me)2]-(5), [N-Me-Tyr(OMe)]-(6), [D-3-Pal2]-(7), [L-Nal2]-(8), [D-Nal2]-(9), [Lys(Nic)2]-(10), [D-Lys(Nic)2]-(11), [D-Phe-(p-NO2)2]-(12). These peptides were evaluated for myotropic activity on the heart of Tenebrio molitor and contractile activity of the foregut of Schistocerca gregaria. Analogues 1-5, 7-9, and 12 retained a weak cardiotropic activity in Tenebrio molitor while peptides 1, 8 and 12 preserved 15-25% of the locust-gut contracting activity of proctolin. Peptides 2, 4 and 7 showed weak inhibitory activity in Schistocerca gregaria foregut, whereas only peptides 2, 4 and 7 reduced the maximum response to appllied proctolin by 64% and 49% respectively, at the 10-6 M concentration.

Close

Details

Original languageEnglish
Pages (from-to)79-85
Number of pages7
JournalPolish Journal of Pharmacology
Volume51
Issue number1
Publication statusPublished - 7 Apr 1999

    Research areas

  • Agonists and antagonists of proctolin, Insect neuropeptide proctolin and analogues, Myotropic effect in insects, Proctolin analogues

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

Related by journal

  1. Myotropic effects of new proctolin analogues modified in the position 5 of peptide chain in insects

    Szeszel-Fedorowicz, W., Rosiński, G., Issberner, J., Osborne, R., Śliwowska, J. & Konopińska, D., 23 Apr 2001, In : Polish Journal of Pharmacology. 53, 1, p. 31-38 8 p.

    Research output: Contribution to journalArticle

  2. New proctolin analogues and their myotropic effects on heart of yellow mealworm Tenebrio molitor L. and foregut of locust - Schistocerca gregaria L.

    Kuczer, M., Rosiński, G., Issberner, J., Osborne, R. & Konopińska, D., 1 Jan 1998, In : Polish Journal of Pharmacology. 50, 2, p. 143-150 8 p.

    Research output: Contribution to journalArticle

ID: 255577862