Skip to content

Research at St Andrews

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs

Research output: Contribution to journalArticle

DOI

Author(s)

S. Hong Lee, Stephan Ripke, Benjamin M. Neale, Stephen V. Faraone, Shaun M. Purcell, Roy H. Perlis, Bryan J. Mowry, Anita Thapar, Michael E. Goddard, John S. Witte, Devin Absher, Ingrid Agartz, Huda Akil, Farooq Amin, Ole A. Andreassen, Adebayo Anjorin, Richard Anney, Verneri Anttila, Dan E. Arking, Philip Asherson & 32 others Maria H. Azevedo, Lena Backlund, Judith A. Badner, Anthony J. Bailey, Tobias Banaschewski, Jack D. Barchas, Michael R. Barnes, Thomas B. Barrett, Nicholas Bass, Agatino Battaglia, Michael Bauer, Monica Bayes, Frank Bellivier, Sarah E. Bergen, Wade Berrettini, Catalina Betancur, Thomas Bettecken, Joseph Biederman, Elisabeth B. Binder, Donald W. Black, Douglas H. R. Blackwood, Cinnamon S. Bloss, Michael Boehnke, Dorret I. Boomsma, Gerome Breen, Rene Breuer, Richard Bruggeman, Paul Cormican, Nancy G. Buccola, Lindsey Kent, Cross-Disorder Grp Psychiat Genomi, Int Inflammatory Bowel Dis Genetic

School/Research organisations

Abstract

Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared genetic etiology, we use genome-wide genotype data from the Psychiatric Genomics Consortium (PGC) for cases and controls in schizophrenia, bipolar disorder, major depressive disorder, autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). We apply univariate and bivariate methods for the estimation of genetic variation within and covariation between disorders. SNPs explained 17-29% of the variance in liability. The genetic correlation calculated using common SNPs was high between schizophrenia and bipolar disorder (0.68 +/- 0.04 s.e.), moderate between schizophrenia and major depressive disorder (0.43 +/- 0.06 s.e.), bipolar disorder and major depressive disorder (0.47 +/- 0.06 s.e.), and ADHD and major depressive disorder (0.32 +/- 0.07 s.e.), low between schizophrenia and ASD (0.16 +/- 0.06 s.e.) and non-significant for other pairs of disorders as well as between psychiatric disorders and the negative control of Crohn's disease. This empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.

Close

Details

Original languageEnglish
Pages (from-to)984-+
Number of pages12
JournalNature Genetics
Volume45
Issue number9
DOIs
Publication statusPublished - Sep 2013

    Research areas

  • attention-deficit/hyperactivity disorder (ADHD), Deficit hyperactivity disorder , Autism spectrum disorders, Major Depressive Disorder, Bipolar Disorder, Common SNPs, Crohns-disease, Schizophrenia, Risk, Association

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. A case-control genome-wide association study of ADHD discovers a novel association with the tenascin R (TNR) gene

    Hawi, Z., Yates, H., Pinar, A., Johnson, B., Tong, J., Pugsley, K., Dark, C., Pauper, M., Klein, M., Heussler, H. S., Vance, A., Hiscock, H., Fornito, A., Tiego, J., Finlay, A., Franke, B., Gill, M., Kent, L. S. & Bellgrove, M. A., 18 Dec 2018, In : Translational Psychiatry. 8, 8 p., 284.

    Research output: Contribution to journalArticle

  2. Rare DNA variants in the brain derived neurotrophic factor gene increase risk for attention deficit hyperactivity disorder: a next generation sequencing study

    Hawi, Z., Cummins, T. D. R., Tong, J., Arcos-Burgos, M., Zhao, Q., Matthews, N., Newman, D. P., Johnson, B., Vance, A., Heussler, H. S., Levy, F., Easteal, S., Wray, N., Kenny, E., Morris, D., Kent, L., Gill, M. & Bellgrove, M., Apr 2017, In : Molecular Psychiatry. Advance online, p. 580-584 5 p.

    Research output: Contribution to journalArticle

  3. GLRB allelic variation associated with agoraphobic cognitions, increased startle response and fear network activation: a potential neurogenetic pathway to panic disorder

    Deckert, J., Weber, H., Villmann, C., Lonsdorf, T. B., Richter, J., Andreatta, M., Arias-Vasquez, A., Hommers, L., Kent, L., Schartner, C., Cichon, S., Wolf, C., Schaefer, N., von Collenberg, C. R., Wachter, B., Blum, R., Schümann, D., Scharfenort, R., Schumacher, J., Forstner, A. J. & 27 othersBaumann, C., Schiele, M. A., Notzon, S., Zwanzger, P., Janzing, J. G. E., Galesloot, T., Kiemeney, L. A., Gajewska, A., Glotzbach-Schoon, E., Mühlberger, A., Alpers, G., Fydrich, T., Fehm, L., Gerlach, A. L., Kircher, T., Lang, T., Ströhle, A., Arolt, V., Wittchen, H-U., Kalisch, R., Büchel, C., Hamm, A., Nöthen, M. M., Romanos, M., Domschke, K., Pauli, P. & Reif, A., 2017, In : Molecular Psychiatry. 22, p. 1431-1439 9 p.

    Research output: Contribution to journalArticle

  4. Pathway analysis in attention deficit hyperactivity disorder: an ensemble approach

    Mooney, M. A., McWeeney, S. K., Faraone, S. V., Hinney, A., Hebebrand, J., IMAGE2 Consortium, German ADHD GWAS Group, Nigg, J. T. & Wilmot, B., Sep 2016, In : American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics . 171, 6, p. 815-826

    Research output: Contribution to journalArticle

  5. Psychiatric gene discoveries shape evidence on ADHD's biology

    Thapar, A., Martin, J., Mick, E., Arias Vásquez, A., Langley, K., Scherer, S. W., Schachar, R., Crosbie, J., Williams, N., Franke, B., Elia, J., Glessner, J., Hakonarson, H., Owen, M. J., Faraone, S. V., O'Donovan, M. C., Holmans, P. & IMAGE 2 Consortium (incl Kent L), 2016, In : Molecular Psychiatry. 21, p. 1202-1207 6 p.

    Research output: Contribution to journalArticle

Related by journal

  1. Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

    Davies, M. R., McIntyre, L., Mutreja, A., Lacey, J. A., Lees, J. A., Towers, R. J., Duchêne, S., Smeesters, P. R., Frost, H. R., Price, D. J., Holden, M. T. G., David, S., Giffard, P. M., Worthing, K. A., Seale, A. C., Berkley, J. A., Harris, S. R., Rivera-Hernandez, T., Berking, O., Cork, A. J. & 18 othersTorres, R. S. L. A., Lithgow, T., Strugnell, R. A., Bergmann, R., Nitsche-Schmitz, P., Chhatwal, G. S., Bentley, S. D., Fraser, J. D., Moreland, N. J., Carapetis, J. R., Steer, A. C., Parkhill, J., Saul, A., Williamson, D. A., Currie, B. J., Tong, S. Y. C., Dougan, G. & Walker, M. J., Jun 2019, In : Nature Genetics. 51, 6, p. 1035-1043

    Research output: Contribution to journalArticle

  2. Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets

    Wedge, D. C., Gundem, G., Mitchell, T., Woodstock, D. J., Martincorena, I., Ghori, M., Zamora, J., Butler, A., Whitaker, H., Kote-Jarai, Z., Alexandrov, L. B., Van Loo, P., Massie, C. E., Dentro, S., Warren, A. Y., Verrill, C., Berney, D. M., Dennis, N., Merson, S., Hawkins, S. & 68 othersHowat, W., Lu, Y-J., Lambert, A., Kay, J., Kremeyer, B., Karaszi, K., Camacho, N., Luxton, H., Marsden, L., Edwards, S., Matthews, L., Bo, V., Leongamornlert, D., McLaren, S., Ng, A., Yu, Y., Zhang, H., Dadaev, T., Thomas, S., Easton, D. F., Ahmed, M., Bancroft, E., Fisher, C., Livni, N., Nicol, D., Tavaré, S., Gill, P., Greenman, C., Khoo, V., Van As, N., Kumar, P., Ogden, C., Cahill, D., Thompson, A., Mayer, E., Rowe, E., Dudderidge, T., Gnanapragasam, V., Shah, N. C., Raine, K., Jones, D., Menzies, A., Stebbings, L., Teague, J., Hazell, S., Corbishley, C., CamCaP Study Group, de Bono, J., Attard, G., Isaacs, W., Visakorpi, T., Fraser, M., Boutros, P. C., Bristow, R. G., Workman, P., Sander, C., The TCGA Consortium, Hamdy, F. C., Futreal, A., McDermott, U., Al-Lazikani, B., Lynch, A., Bova, G. S., Foster, C. S., Brewer, D. S., Neal, D. E., Cooper, C. S. & Eeles, R. A., 16 Apr 2018, In : Nature Genetics. 50, p. 682-692 16 p.

    Research output: Contribution to journalArticle

  3. Mutational signatures in esophageal adenocarcinoma define etiologically distinct subgroups with therapeutic relevance

    Secrier, M., Li, X., de Silva, N., Eldridge, M. D., Contino, G., Bornschein, J., MacRae, S., Grehan, N., O'Donovan, M., Miremadi, A., Yang, T-P., Bower, L., Chettouh, H., Crawte, J., Galeano-Dalmau, N., Grabowska, A., Saunders, J., Underwood, T., Waddell, N., Barbour, A. P. & 7 othersNutzinger, B., Achilleos, A., Edwards, P. A. W., Lynch, A. G., Tavaré, S., Fitzgerald, R. C. & Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, 5 Sep 2016, In : Nature Genetics. 48, 10, p. 1131-1141 11 p.

    Research output: Contribution to journalArticle

  4. Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

    Cooper, C. S., Eeles, R., Wedge, D. C., Van Loo, P., Gundem, G., Alexandrov, L. B., Kremeyer, B., Butler, A., Lynch, A. G., Camacho, N., Massie, C. E., Kay, J., Luxton, H. J., Edwards, S., Kote-Jarai, Z., Dennis, N., Merson, S., Leongamornlert, D., Zamora, J., Corbishley, C. & 51 othersThomas, S., Nik-Zainal, S., O'Meara, S., Matthews, L., Clark, J., Hurst, R., Mithen, R., Bristow, R. G., Boutros, P. C., Fraser, M., Cooke, S., Raine, K., Jones, D., Menzies, A., Stebbings, L., Hinton, J., Teague, J., McLaren, S., Mudie, L., Hardy, C., Anderson, E., Joseph, O., Goody, V., Robinson, B., Maddison, M., Gamble, S., Greenman, C., Berney, D., Hazell, S., Livni, N., Fisher, C., Ogden, C., Kumar, P., Thompson, A., Woodhouse, C., Nicol, D., Mayer, E., Dudderidge, T., Shah, N. C., Gnanapragasam, V., Voet, T., Campbell, P., Futreal, A., Easton, D., Warren, A. Y., Foster, C. S., Stratton, M. R., Whitaker, H. C., McDermott, U., Brewer, D. S. & Neal, D. E., 28 Apr 2015, In : Nature Genetics. 47, 4, p. 367-372 6 p.

    Research output: Contribution to journalArticle

  5. Whole-genome sequencing provides new insights into the clonal architecture of Barrett's esophagus and esophageal adenocarcinoma

    Ross-Innes, C. S., Becq, J., Warren, A., Cheetham, R. K., Northen, H., O'Donovan, M., Malhotra, S., Di Pietro, M., Ivakhno, S., He, M., Weaver, J. M. J., Lynch, A. G., Kingsbury, Z., Ross, M., Humphray, S., Bentley, D., Fitzgerald, R. C., Hayes, S. J., Ang, Y., Welch, I. & 85 othersPreston, S., Oakes, S., Save, V., Skipworth, R., Tucker, O., Davies, J., Crichton, C., Schusterreiter, C., Underwood, T., Noble, F., Stacey, B., Kelly, J., Byrne, J., Haydon, A., Sharland, D., Owsley, J., Barr, H., Lagergren, J., Gossage, J., Davies, A., Mason, R., Chang, F., Zylstra, J., Sanders, G., Wheatley, T., Berrisford, R., Bracey, T., Harden, C., Bunting, D., Roques, T., Nobes, J., Loo, S., Lewis, M., Cheong, E., Priest, O., Parsons, S. L., Soomro, I., Kaye, P., Saunders, J., Pang, V., Welch, N., Catton, J. A., Duffy, J. P., Ragunath, K., Lovat, L., Haidry, R., Miah, H., Kerr, S., Eneh, V., Butawan, R., Lewis, M., Cheong, E., Kumar, B., Igali, L., Walton, S., Dann, A., Safranek, P., Hindmarsh, A., Sudjendran, V., Scott, M., Cluroe, A., Miremadi, A., Mahler-Araujo, B., Nutzinger, B., Peters, C., Abdullahi, Z., Crawte, J., MacRae, S., Noorani, A., Elliott, R. F., Bower, L., Edwards, P., Tavare, S., Eldridge, M., Bornschein, J., Secrier, M., Yang, T. P., O'Neill, J. R., Adamczuk, K., Lao-Sirieix, P., Grehan, N., Smith, L., Lishman, S., Beardsmore, D. & Dawson, S., 27 Aug 2015, In : Nature Genetics. 47, 9, p. 1038-1046 9 p.

    Research output: Contribution to journalArticle

ID: 73622188