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Genomic tools and selective breeding in molluscs

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Genomic tools and selective breeding in molluscs. / Hollenbeck, Christopher M.; Johnston, Ian A.

In: Frontiers in Genetics, Vol. 9, 253, 18.07.2018.

Research output: Contribution to journalReview article

Harvard

Hollenbeck, CM & Johnston, IA 2018, 'Genomic tools and selective breeding in molluscs' Frontiers in Genetics, vol. 9, 253. https://doi.org/10.3389/fgene.2018.00253

APA

Hollenbeck, C. M., & Johnston, I. A. (2018). Genomic tools and selective breeding in molluscs. Frontiers in Genetics, 9, [253]. https://doi.org/10.3389/fgene.2018.00253

Vancouver

Hollenbeck CM, Johnston IA. Genomic tools and selective breeding in molluscs. Frontiers in Genetics. 2018 Jul 18;9. 253. https://doi.org/10.3389/fgene.2018.00253

Author

Hollenbeck, Christopher M. ; Johnston, Ian A. / Genomic tools and selective breeding in molluscs. In: Frontiers in Genetics. 2018 ; Vol. 9.

Bibtex - Download

@article{2febfa1aac13444f8c245994a79307f3,
title = "Genomic tools and selective breeding in molluscs",
abstract = "The production of most farmed molluscs, including mussels, oysters, scallops, abalone, and clams, is heavily dependent on natural seed from the plankton. Closing the lifecycle of species in hatcheries can secure independence from wild stocks and enables long-term genetic improvement of broodstock through selective breeding. Genomic techniques have the potential to revolutionize hatchery-based selective breeding by improving our understanding of the characteristics of mollusc genetics that can pose a challenge for intensive aquaculture and by providing a new suite of tools for genetic improvement. Here we review characteristics of the life history and genetics of molluscs including high fecundity, self-fertilization, high genetic diversity, genetic load, high incidence of deleterious mutations and segregation distortion and critically assess their impact on the design and effectiveness of selective breeding strategies. A survey of the results of current breeding programs in the literature show that selective breeding with inbreeding control is likely the best strategy for genetic improvement of most molluscs, and on average growth rate can be improved by 10{\%} per generation and disease resistance by 15{\%} per generation across the major farmed species by implementing individual or family-based selection. Rapid advances in sequencing technology have resulted in a wealth of genomic resources for key species with the potential to greatly improve hatchery-based selective breeding of molluscs. In this review, we catalogue the range of genomic resources currently available for molluscs of aquaculture interest and discuss the bottlenecks, including lack of high-quality reference genomes and the relatively high cost of genotyping, as well as opportunities for applying genomics-based selection.",
keywords = "Aquaculture, Genomics, SNP genotyping, Heritability, Marker assisted selection, Genomic selection, Molluscs, Selective breeding",
author = "Hollenbeck, {Christopher M.} and Johnston, {Ian A.}",
note = "This review of genetic resources and selective breeding in molluscs was carried out as part of the European Marine Biological Research Infrastructure Cluster (EMBRIC) project funded by the European Union's Horizon 2020 research and innovation program under grant agreement No 654008.",
year = "2018",
month = "7",
day = "18",
doi = "10.3389/fgene.2018.00253",
language = "English",
volume = "9",
journal = "Frontiers in Genetics",
issn = "1664-8021",
publisher = "Frontiers Media S. A.",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Genomic tools and selective breeding in molluscs

AU - Hollenbeck, Christopher M.

AU - Johnston, Ian A.

N1 - This review of genetic resources and selective breeding in molluscs was carried out as part of the European Marine Biological Research Infrastructure Cluster (EMBRIC) project funded by the European Union's Horizon 2020 research and innovation program under grant agreement No 654008.

PY - 2018/7/18

Y1 - 2018/7/18

N2 - The production of most farmed molluscs, including mussels, oysters, scallops, abalone, and clams, is heavily dependent on natural seed from the plankton. Closing the lifecycle of species in hatcheries can secure independence from wild stocks and enables long-term genetic improvement of broodstock through selective breeding. Genomic techniques have the potential to revolutionize hatchery-based selective breeding by improving our understanding of the characteristics of mollusc genetics that can pose a challenge for intensive aquaculture and by providing a new suite of tools for genetic improvement. Here we review characteristics of the life history and genetics of molluscs including high fecundity, self-fertilization, high genetic diversity, genetic load, high incidence of deleterious mutations and segregation distortion and critically assess their impact on the design and effectiveness of selective breeding strategies. A survey of the results of current breeding programs in the literature show that selective breeding with inbreeding control is likely the best strategy for genetic improvement of most molluscs, and on average growth rate can be improved by 10% per generation and disease resistance by 15% per generation across the major farmed species by implementing individual or family-based selection. Rapid advances in sequencing technology have resulted in a wealth of genomic resources for key species with the potential to greatly improve hatchery-based selective breeding of molluscs. In this review, we catalogue the range of genomic resources currently available for molluscs of aquaculture interest and discuss the bottlenecks, including lack of high-quality reference genomes and the relatively high cost of genotyping, as well as opportunities for applying genomics-based selection.

AB - The production of most farmed molluscs, including mussels, oysters, scallops, abalone, and clams, is heavily dependent on natural seed from the plankton. Closing the lifecycle of species in hatcheries can secure independence from wild stocks and enables long-term genetic improvement of broodstock through selective breeding. Genomic techniques have the potential to revolutionize hatchery-based selective breeding by improving our understanding of the characteristics of mollusc genetics that can pose a challenge for intensive aquaculture and by providing a new suite of tools for genetic improvement. Here we review characteristics of the life history and genetics of molluscs including high fecundity, self-fertilization, high genetic diversity, genetic load, high incidence of deleterious mutations and segregation distortion and critically assess their impact on the design and effectiveness of selective breeding strategies. A survey of the results of current breeding programs in the literature show that selective breeding with inbreeding control is likely the best strategy for genetic improvement of most molluscs, and on average growth rate can be improved by 10% per generation and disease resistance by 15% per generation across the major farmed species by implementing individual or family-based selection. Rapid advances in sequencing technology have resulted in a wealth of genomic resources for key species with the potential to greatly improve hatchery-based selective breeding of molluscs. In this review, we catalogue the range of genomic resources currently available for molluscs of aquaculture interest and discuss the bottlenecks, including lack of high-quality reference genomes and the relatively high cost of genotyping, as well as opportunities for applying genomics-based selection.

KW - Aquaculture

KW - Genomics

KW - SNP genotyping

KW - Heritability

KW - Marker assisted selection

KW - Genomic selection

KW - Molluscs

KW - Selective breeding

U2 - 10.3389/fgene.2018.00253

DO - 10.3389/fgene.2018.00253

M3 - Review article

VL - 9

JO - Frontiers in Genetics

T2 - Frontiers in Genetics

JF - Frontiers in Genetics

SN - 1664-8021

M1 - 253

ER -

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ID: 255029781