Skip to content

Research at St Andrews

Genomics of natural populations of Staphylococcus aureus

Research output: Contribution to journalReview article

Author(s)

J. Ross Fitzgerald, Matthew T G Holden

School/Research organisations

Abstract

Staphylococcus aureus is a major human pathogen and an important cause of livestock infections. The first S. aureus genomes to be published, 14 years ago, provided the first view of genome structure and gene content. Since then, thousands of genomes from a wide array of strains from different sources have been sequenced. Comparison of these sequences has resulted in broad insights into population structure, bacterial evolution, clone emergence and expansion, and the molecular basis of niche adaptation. Furthermore, this information is now being applied clinically in outbreak investigations to inform infection control measures and to determine appropriate treatment regimens. In this review, we summarize some of the broad insights into S. aureus biology gained from the analysis of genomes and discuss future directions and opportunities in this dynamic field of research.

Close

Details

Original languageEnglish
Pages (from-to)459-478
Number of pages20
JournalAnnual Review of Microbiology
Volume70
Early online date29 Jul 2016
DOIs
Publication statusPublished - 8 Sep 2016

    Research areas

  • Staphylococcus aureas, MRSA, Genome, Host range, Pathogenesis

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Antimicrobial resistance in atopic dermatitis: need for an urgent rethink

    Harkins, C. P., Holden, M. T. G. & Irvine, A. D., Mar 2019, In : Annals of Allergy Asthma & Immunology. 122, 3, p. 236-240 5 p.

    Research output: Contribution to journalArticle

  2. Molecular epidemiology and expression of capsular polysaccharides in Staphylococcus aureus clinical isolates in the United States

    Mohamed, N., Timofeyeva, Y., Jamrozy, D., Rojas, E., Hao, L., Silmon de Monerri, N. C., Hawkins, J., Singh, G., Cai, B., Liberator, P., Sebastian, S., Donald, R. G. K., Scully, I. L., Jones, C. H., Creech, C. B., Thomsen, I., Parkhill, J., Peacock, S. J., Jansen, K. U., Holden, M. T. G. & 1 othersAnderson, A. S., 14 Jan 2019, In : PLoS ONE. 14, 1, 33 p., e0208356.

    Research output: Contribution to journalArticle

  3. Mobile-genetic-element-encoded hypertolerance to copper protects Staphylococcus aureus from killing by host phagocytes

    Zapotoczna, M., Riboldi, G. P., Moustafa, A. M., Dickson, E., Narechania, A., Morrissey, J. A., Planet, P. J., Holden, M. T. G., Waldron, K. J. & Geoghegan, J. A., 16 Oct 2018, In : mBio. 9, 5, 15 p., e00550-18.

    Research output: Contribution to journalArticle

  4. The widespread use of topical antimicrobials enriches for resistance in Staphylococcus aureus isolated from Atopic Dermatitis patients

    Harkins, C. P., McAleer, M. A., Bennett, D., McHugh, M., Fleury, O. M., Pettigrew, K. A., Oravcová, K., Parkhill, J., Proby, C. M., Dawe, R. S., Geoghegan, J. A., Irvine, A. D. & Holden, M. T. G., 24 Jul 2018, In : British Journal of Dermatology. Early View, 8 p.

    Research output: Contribution to journalArticle

ID: 244842338