Skip to content

Research at St Andrews

Global and regional dissemination and evolution of Burkholderia pseudomallei

Research output: Contribution to journalArticle

DOI

Open Access permissions

Open

Author(s)

Claire Chewapreecha, Matthew T. G. Holden, Minna Vehkala, Niko Välimäki, Zhirong Yang, Simon R. Harris, Alison E. Mather, Apichai Tuanyok, Birgit De Smet, Simon Le Hello, Chantal Bizet, Mark Mayo, Vanaporn Wuthiekanun, Direk Limmathurotsakul, Rattanaphone Phetsouvanh, Brian G. Spratt, Jukka Corander, Paul Keim, Gordon Dougan, David A. B. Dance & 3 others Bart J. Currie, Julian Parkhill, Sharon J. Peacock

School/Research organisations

Abstract

The environmental bacterium Burkholderia pseudomallei causes an estimated 165,000 cases of human melioidosis per year worldwide and is also classified as a biothreat agent. We used whole genome sequences of 469 B. pseudomallei isolates from 30 countries collected over 79 years to explore its geographic transmission. Our data point to Australia as an early reservoir, with transmission to Southeast Asia followed by onward transmission to South Asia and East Asia. Repeated reintroductions were observed within the Malay Peninsula and between countries bordered by the Mekong River. Our data support an African origin of the Central and South American isolates with introduction of B. pseudomallei into the Americas between 1650 and 1850, providing a temporal link with the slave trade. We also identified geographically distinct genes/variants in Australasian or Southeast Asian isolates alone, with virulence-associated genes being among those over-represented. This provides a potential explanation for clinical manifestations of melioidosis that are geographically restricted.

Close

Details

Original languageEnglish
Article number16263
JournalNature Microbiology
Volume2
DOIs
StatePublished - 23 Jan 2017

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. The microevolution and epidemiology of Staphylococcus aureus colonization during atopic eczema disease flare

    Harkins, C. P., Pettigrew, K. A., Oravcová, K., Gardner, J., Hearn, R. M. R., Rice, D., Mather, A. E., Parkhill, J., Brown, S. J., Proby, C. M. & Holden, M. T. G. 23 Sep 2017 In : Journal of Investigative Dermatology. 138, 2, p. 336-343

    Research output: Contribution to journalArticle

  2. Pseudomonas aeruginosa intensive care unit outbreak: winnowing of transmissions with molecular and genomic typing

    Parcell, B. J., Oravcova, K., Pinheiro, M., Holden, M. T. G., Phillips, G., Turton, J. F. & Gillespie, S. H. 8 Dec 2017 In : Journal of Hospital Infection. In press

    Research output: Contribution to journalArticle

  3. Haem-iron plays a key role in the regulation of the Ess/type VII secretion system of Staphylococcus aureus RN6390

    Casabona, M. G., Kneuper, H., Alferes de Lima, D., Harkins, C. P., Zoltner, M., Hjerde, E., Holden, M. T. G. & Palmer, T. 24 Nov 2017 In : Microbiology. Latest Article

    Research output: Contribution to journalArticle

  4. Functional analysis of the EsaB component of the Staphylococcus aureus Type VII secretion system

    Casabona, M. G., Buchanan, G., Zoltner, M., Harkins, C. P., Holden, M. T. G. & Palmer, T. 22 Nov 2017 In : Microbiology. Latest Article, 13 p.

    Research output: Contribution to journalArticle

  5. The genetic diversity of Staphylococcus aureus colonisation in atopic eczema disease flare

    Harkins, C. P., Pettigrew, K. A., Oravcova, K., Gardner, J., Hearn, R., Rice, D., Mather, A. E., Parkhill, J., Brown, S. J., Proby, C. M. & Holden, M. T. Oct 2017 In : Journal of Investigative Dermatology. 137, 10, p. S258-S258 1 p.

    Research output: Contribution to journalAbstract

ID: 249027996