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Global and regional dissemination and evolution of Burkholderia pseudomallei

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Global and regional dissemination and evolution of Burkholderia pseudomallei. / Chewapreecha, Claire; Holden, Matthew T. G.; Vehkala, Minna; Välimäki, Niko; Yang, Zhirong; Harris, Simon R.; Mather, Alison E.; Tuanyok, Apichai; De Smet, Birgit; Le Hello, Simon; Bizet, Chantal; Mayo, Mark; Wuthiekanun, Vanaporn; Limmathurotsakul, Direk; Phetsouvanh, Rattanaphone; Spratt, Brian G.; Corander, Jukka; Keim, Paul; Dougan, Gordon; Dance, David A. B.; Currie, Bart J.; Parkhill, Julian; Peacock, Sharon J.

In: Nature Microbiology, Vol. 2, 16263, 23.01.2017.

Research output: Contribution to journalArticle

Harvard

Chewapreecha, C, Holden, MTG, Vehkala, M, Välimäki, N, Yang, Z, Harris, SR, Mather, AE, Tuanyok, A, De Smet, B, Le Hello, S, Bizet, C, Mayo, M, Wuthiekanun, V, Limmathurotsakul, D, Phetsouvanh, R, Spratt, BG, Corander, J, Keim, P, Dougan, G, Dance, DAB, Currie, BJ, Parkhill, J & Peacock, SJ 2017, 'Global and regional dissemination and evolution of Burkholderia pseudomallei', Nature Microbiology, vol. 2, 16263. https://doi.org/10.1038/nmicrobiol.2016.263

APA

Chewapreecha, C., Holden, M. T. G., Vehkala, M., Välimäki, N., Yang, Z., Harris, S. R., ... Peacock, S. J. (2017). Global and regional dissemination and evolution of Burkholderia pseudomallei. Nature Microbiology, 2, [16263]. https://doi.org/10.1038/nmicrobiol.2016.263

Vancouver

Chewapreecha C, Holden MTG, Vehkala M, Välimäki N, Yang Z, Harris SR et al. Global and regional dissemination and evolution of Burkholderia pseudomallei. Nature Microbiology. 2017 Jan 23;2. 16263. https://doi.org/10.1038/nmicrobiol.2016.263

Author

Chewapreecha, Claire ; Holden, Matthew T. G. ; Vehkala, Minna ; Välimäki, Niko ; Yang, Zhirong ; Harris, Simon R. ; Mather, Alison E. ; Tuanyok, Apichai ; De Smet, Birgit ; Le Hello, Simon ; Bizet, Chantal ; Mayo, Mark ; Wuthiekanun, Vanaporn ; Limmathurotsakul, Direk ; Phetsouvanh, Rattanaphone ; Spratt, Brian G. ; Corander, Jukka ; Keim, Paul ; Dougan, Gordon ; Dance, David A. B. ; Currie, Bart J. ; Parkhill, Julian ; Peacock, Sharon J. / Global and regional dissemination and evolution of Burkholderia pseudomallei. In: Nature Microbiology. 2017 ; Vol. 2.

Bibtex - Download

@article{7c8e0c1c570b401389a617200a8a0adb,
title = "Global and regional dissemination and evolution of Burkholderia pseudomallei",
abstract = "The environmental bacterium Burkholderia pseudomallei causes an estimated 165,000 cases of human melioidosis per year worldwide and is also classified as a biothreat agent. We used whole genome sequences of 469 B. pseudomallei isolates from 30 countries collected over 79 years to explore its geographic transmission. Our data point to Australia as an early reservoir, with transmission to Southeast Asia followed by onward transmission to South Asia and East Asia. Repeated reintroductions were observed within the Malay Peninsula and between countries bordered by the Mekong River. Our data support an African origin of the Central and South American isolates with introduction of B. pseudomallei into the Americas between 1650 and 1850, providing a temporal link with the slave trade. We also identified geographically distinct genes/variants in Australasian or Southeast Asian isolates alone, with virulence-associated genes being among those over-represented. This provides a potential explanation for clinical manifestations of melioidosis that are geographically restricted.",
author = "Claire Chewapreecha and Holden, {Matthew T. G.} and Minna Vehkala and Niko V{\"a}lim{\"a}ki and Zhirong Yang and Harris, {Simon R.} and Mather, {Alison E.} and Apichai Tuanyok and {De Smet}, Birgit and {Le Hello}, Simon and Chantal Bizet and Mark Mayo and Vanaporn Wuthiekanun and Direk Limmathurotsakul and Rattanaphone Phetsouvanh and Spratt, {Brian G.} and Jukka Corander and Paul Keim and Gordon Dougan and Dance, {David A. B.} and Currie, {Bart J.} and Julian Parkhill and Peacock, {Sharon J.}",
year = "2017",
month = "1",
day = "23",
doi = "10.1038/nmicrobiol.2016.263",
language = "English",
volume = "2",
journal = "Nature Microbiology",
issn = "2058-5276",
publisher = "Nature publishing group",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Global and regional dissemination and evolution of Burkholderia pseudomallei

AU - Chewapreecha, Claire

AU - Holden, Matthew T. G.

AU - Vehkala, Minna

AU - Välimäki, Niko

AU - Yang, Zhirong

AU - Harris, Simon R.

AU - Mather, Alison E.

AU - Tuanyok, Apichai

AU - De Smet, Birgit

AU - Le Hello, Simon

AU - Bizet, Chantal

AU - Mayo, Mark

AU - Wuthiekanun, Vanaporn

AU - Limmathurotsakul, Direk

AU - Phetsouvanh, Rattanaphone

AU - Spratt, Brian G.

AU - Corander, Jukka

AU - Keim, Paul

AU - Dougan, Gordon

AU - Dance, David A. B.

AU - Currie, Bart J.

AU - Parkhill, Julian

AU - Peacock, Sharon J.

PY - 2017/1/23

Y1 - 2017/1/23

N2 - The environmental bacterium Burkholderia pseudomallei causes an estimated 165,000 cases of human melioidosis per year worldwide and is also classified as a biothreat agent. We used whole genome sequences of 469 B. pseudomallei isolates from 30 countries collected over 79 years to explore its geographic transmission. Our data point to Australia as an early reservoir, with transmission to Southeast Asia followed by onward transmission to South Asia and East Asia. Repeated reintroductions were observed within the Malay Peninsula and between countries bordered by the Mekong River. Our data support an African origin of the Central and South American isolates with introduction of B. pseudomallei into the Americas between 1650 and 1850, providing a temporal link with the slave trade. We also identified geographically distinct genes/variants in Australasian or Southeast Asian isolates alone, with virulence-associated genes being among those over-represented. This provides a potential explanation for clinical manifestations of melioidosis that are geographically restricted.

AB - The environmental bacterium Burkholderia pseudomallei causes an estimated 165,000 cases of human melioidosis per year worldwide and is also classified as a biothreat agent. We used whole genome sequences of 469 B. pseudomallei isolates from 30 countries collected over 79 years to explore its geographic transmission. Our data point to Australia as an early reservoir, with transmission to Southeast Asia followed by onward transmission to South Asia and East Asia. Repeated reintroductions were observed within the Malay Peninsula and between countries bordered by the Mekong River. Our data support an African origin of the Central and South American isolates with introduction of B. pseudomallei into the Americas between 1650 and 1850, providing a temporal link with the slave trade. We also identified geographically distinct genes/variants in Australasian or Southeast Asian isolates alone, with virulence-associated genes being among those over-represented. This provides a potential explanation for clinical manifestations of melioidosis that are geographically restricted.

U2 - 10.1038/nmicrobiol.2016.263

DO - 10.1038/nmicrobiol.2016.263

M3 - Article

VL - 2

JO - Nature Microbiology

JF - Nature Microbiology

SN - 2058-5276

M1 - 16263

ER -

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