Skip to content

Research at St Andrews

Global initiative for meticillin-resistant Staphylococcus aureus pneumonia (GLIMP): an international, observational cohort study

Research output: Contribution to journalArticle

Author(s)

Stefano Aliberti, Luis F Reyes, Paola Faverio, Giovanni Sotgiu, Simone Dore, Alejandro H Rodriguez, Nilam J Soni, Marcos I Restrepo, GLIMP investigators, Devesh Janardan Dhasmana

School/Research organisations

Abstract

BACKGROUND: Antibiotic resistance is a major global health problem and pathogens such as meticillin-resistant Staphylococcus aureus (MRSA) have become of particular concern in the management of lower respiratory tract infections. However, few data are available on the worldwide prevalence and risk factors for MRSA pneumonia. We aimed to determine the point prevalence of MRSA pneumonia and identify specific MRSA risk factors in community-dwelling patients hospitalised with pneumonia.

METHODS: We did an international, multicentre study of community-dwelling, adult patients admitted to hospital with pneumonia who had microbiological tests taken within 24 h of presentation. We recruited investigators from 222 hospitals in 54 countries to gather point-prevalence data for all patients admitted with these characteristics during 4 days randomly selected during the months of March, April, May, and June in 2015. We assessed prevalence of MRSA pneumonia and associated risk factors through logistic regression analysis.

FINDINGS: 3702 patients hospitalised with pneumonia were enrolled, with 3193 patients receiving microbiological tests within 24 h of admission, forming the patient population. 1173 (37%) had at least one pathogen isolated (culture-positive population). The overall prevalence of confirmed MRSA pneumonia was 3·0% (n=95), with differing prevalence between continents and countries. Three risk factors were independently associated with MRSA pneumonia: previous MRSA infection or colonisation (odds ratio 6·21, 95% CI 3·25-11·85), recurrent skin infections (2·87, 1·10-7·45), and severe pneumonia disease (2·39, 1·55-3·68).

INTERPRETATION: This multicountry study shows low prevalence of MRSA pneumonia and specific MRSA risk factors among community-dwelling patients hospitalised with pneumonia.

FUNDING: None.

Close

Details

Original languageEnglish
Pages (from-to)1364-1376
Number of pages13
JournalLancet Infectious Diseases
Volume16
Issue number12
Early online date1 Sep 2016
DOIs
StatePublished - Dec 2016

    Research areas

  • Aged, Cohort Studies, Community-Acquired Infections, Cross Infection, Female, Global Health, Hospitals, Humans, Male, Methicillin Resistance, Methicillin-Resistant Staphylococcus aureus, Pneumonia, Prevalence, Retrospective Studies, Risk Factors, Staphylococcal Infections

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Genomic investigation unmasks evidence of transmission across mycobacterium abscessus cystic fibrosis patients

    Alateah, S., Peters, C., Dhasmana, DJ., Pettigrew, K., Fallon, R., Seagar, A., Sloan, DJ., Laurenson, IF., Holden, M. & Gillespie, S. 15 Dec 2017 In : Thorax. 72, Suppl 3, p. A56-A56

    Research output: Contribution to journalAbstract

  2. Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: an international case-cohort study

    Walsh, S. L. F. , Maher, T. M. , Kolb, M. , Poletti, V. , Nusser, R. , Richeldi, L. , Vancheri, C. , Wilsher, M. L. , Antoniou, K. M. , Behr, J. , Bendstrup, E. , Brown, K. , Calandriello, L. , Corte, T. J. , Cottin, V. , Crestani, B. , Flaherty, K. , Glaspole, I. , Grutters, J. , Inoue, Y. & 25 others Kokosi, M., Kondoh, Y., Kouranos, V., Kreuter, M., Johannson, K., Judge, E., Ley, B., Margaritopoulos, G., Martinez, F. J., Molina-Molina, M., Morais, A., Nunes, H., Raghu, G., Ryerson, C. J., Selman, M., Spagnolo, P., Taniguchi, H., Tomassetti, S., Valeyre, D., Wijsenbeek, M., Wuyts, W., Hansell, D., Wells, A., IPF Project Consortium & Dhasmana, D. J. 31 Aug 2017 In : European Respiratory Journal. 50, 2, 10 p., 1700936

    Research output: Contribution to journalArticle

  3. Burkholderia cepacia complex and limited cutaneous vasculitis in patients with cystic fibrosis: a case series

    Kayria, M., Chris, O., Dhasmana, D. J., Nilesh, M., Hodson, M. E., Khin, G., Diana, B. & Simmonds, N. J. 3 Apr 2017 In : JRSM Open. 8, 4, p. 1-4

    Research output: Contribution to journalArticle

  4. Evaluation of the healthcare burden of Idiopathic Pulmonary Fibrosis (IPF) in Fife, Scotland

    Dhasmana, D. J., Harrison, F., Hartley, T. & Szapiro, D. 13 May 2016

    Research output: Contribution to conferenceAbstract

Related by journal

  1. High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial

    Boeree, M. J. , Heinrich, N. , Aarnoutse, R. , Diacon, A. H. , Dawson, R. , Rehal, S. , Kibiki, G. S. , Churchyard, G. , Sanne, I. , Ntinginya, N. E. , Minja, L. T. , Hunt, R. D. , Charalambous, S. , Hanekom, M. , Semvua, H. H. , Mpagama, S. G. , Manyama, C. , Mtafya, B. , Reither, K. , Wallis, R. S. & 9 others Venter, A., Narunsky, K., Mekota, A., Henne, S., Colbers, A., Plemper van Balen, G., Gillespie, S. H., Phillips, P. P. J. & Hoelscher, M. Jan 2017 In : Lancet Infectious Diseases. 17, 1, p. 39-49 11 p.

    Research output: Contribution to journalArticle

  2. New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects

    Zumla, A. I., Gillespie, S. H., Hoelscher, M., Philips, P. P. J., Cole, S. T., Abubakar, I., McHugh, T. D., Schito, M., Maeurer, M. & Nunn, A. J. Apr 2014 In : Lancet Infectious Diseases. 14, 4, p. 327-40 14 p.

    Research output: Contribution to journalArticle

  3. Whole-genome sequencing for analysis of an outbreak of meticillin-resistant Staphylococcus aureus: a descriptive study

    Harris, S. R., Cartwright, E. J. P., Toeroek, M. E., Holden, M. T. G., Brown, N. M., Ogilvy-Stuart, A. L., Ellington, M. J., Quail, M. A., Bentley, S. D., Parkhill, J. & Peacock, S. J. Feb 2013 In : Lancet Infectious Diseases. 13, 2, p. 130-136 7 p.

    Research output: Contribution to journalArticle

  4. Moxifloxacin for tuberculosis

    Singh, K. P., Brown, M., Murphy, M. E. & Gillespie, S. H. Mar 2012 In : Lancet Infectious Diseases. 12, 3, p. 176-176 1 p.

    Research output: Contribution to journalLetter

ID: 252558196