Skip to content

Research at St Andrews

Glucocorticoid programming of neuroimmune function

Research output: Contribution to journalReview article

DOI

Open Access permissions

Open

Author(s)

David J. Walker, Karen A. Spencer

School/Research organisations

Abstract

Throughout life physiological systems strive to maintain homeostasis and these systems are susceptible to exposure to maternal or environmental perturbations, particularly during embryonic development. In some cases, these perturbations may influence genetic and physiological processes that permanently alter the functioning of these physiological systems; a process known as developmental programming. In recent years, the neuroimmune system has garnered attention for its fundamental interactions with key hormonal systems, such as the hypothalamic pituitary adrenal (HPA) axis. The ultimate product of this axis, the glucocorticoid hormones, play a key role in modulating immune responses within the periphery and the CNS as part of the physiological stress response. It is well-established that elevated glucocorticoids induced by developmental stress exert profound short and long-term physiological effects, yet there is relatively little information of how these effects are manifested within the neuroimmune system. Pre and post-natal periods are prime candidates for manipulation in order to uncover the physiological mechanisms that underlie glucocorticoid programming of neuroimmune responses. Understanding the potential programming role of glucocorticoids may be key in uncovering vulnerable windows of CNS susceptibility to stressful experiences during embryonic development and improve our use of glucocorticoids as therapeutics in the treatment of neurodegenerative diseases.
Close

Details

Original languageEnglish
JournalGeneral and Comparative Endocrinology
VolumeIn press
Early online date17 Jul 2017
DOIs
StateE-pub ahead of print - 17 Jul 2017

    Research areas

  • Cytokines, Developmental programming, Glucocorticoids, Microglia, Neuroimmune, Stress

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. A marker of biological age explains individual variation in the strength of the adult stress response

    Andrews, C., Nettle, D., Larriva, M., Gillespie, R., Reichert, S., Brilot, B. O., Bedford, T., Monaghan, P., Spencer, K. A. & Bateson, M. 27 Sep 2017 In : Royal Society Open Science. 4, 13 p., 171208

    Research output: Contribution to journalArticle

  2. Transgenerational transmission of a stress-coping phenotype programmed by early-life stress in the Japanese quail

    Zimmer, C., Larriva Hormigos, M., Boogert, N. J. & Spencer, K. A. 7 Apr 2017 In : Scientific Reports. 7, 19 p., 46125

    Research output: Contribution to journalArticle

Related by journal

Related by journal

  1. General and Comparative Endocrinology (Journal)

    Cramb, G. (Member of editorial board)
    2008 → …

    Activity: Publication peer-review and editorial workEditor of research journal

  2. General and Comparative Endocrinology (Journal)

    Cramb, G. (Member of editorial board)
    1 Jan 200831 Dec 2012

    Activity: Publication peer-review and editorial workEditor of research journal

  3. General and Comparative Endocrinology (Journal)

    Hazon, N. (Member of editorial board)
    2005 → …

    Activity: Publication peer-review and editorial workEditor of research journal

ID: 250544456