Research output: Research - peer-review › Article
M Guillermina Casabona, Holger Kneuper, Daniela Alferes de Lima, Catriona P Harkins, Martin Zoltner, Erik Hjerde, Matthew T. G. Holden, Tracy Palmer
The Staphylococcus aureus type VII protein secretion system (T7SS) plays important roles in virulence and intra-species competition. Here we show that the T7SS in strain RN6390 is activated by supplementing the growth medium with haemoglobin, and its cofactor haemin (haem B). Transcript analysis and secretion assays suggest that activation by haemin occurs at a transcriptional and a post-translational level. Loss of T7 secretion activity by deletion of essC results in upregulation of genes required for iron acquisition. Taken together these findings suggest that the T7SS plays a role in iron homeostasis in at least some S. aureus strains.
Original language | English |
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Journal | Microbiology |
Volume | Latest Article |
Early online date | 24 Nov 2017 |
DOIs | |
State | E-pub ahead of print - 24 Nov 2017 |
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Research output: Research - peer-review › Article
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Research output: Research - peer-review › Article
Research output: Research - peer-review › Article
Research output: Research - peer-review › Article
Research output: Research - peer-review › Article
Activity: Publication peer-review and editorial work › Editor of research journal
ID: 251666266