Skip to content

Research at St Andrews

Handheld probe for quantitative micro-elastography

Research output: Contribution to journalArticle

DOI

Open Access permissions

Open

Standard

Handheld probe for quantitative micro-elastography. / Fang, Qi; Krajancich, Brooke; Chin, Lixin; Zilkens, Renate; Curatolo, Andrea; Frewer, Luke; Anstie, James D.; Wijesinghe, Philip; Hall, Colin; Dessauvagie, Benjamin F.; Latham, Bruce; Saunders, Christobel M.; Kennedy, Brendan F.

In: Biomedical Optics Express, Vol. 10, No. 8, 01.08.2019, p. 4034-4049.

Research output: Contribution to journalArticle

Harvard

Fang, Q, Krajancich, B, Chin, L, Zilkens, R, Curatolo, A, Frewer, L, Anstie, JD, Wijesinghe, P, Hall, C, Dessauvagie, BF, Latham, B, Saunders, CM & Kennedy, BF 2019, 'Handheld probe for quantitative micro-elastography', Biomedical Optics Express, vol. 10, no. 8, pp. 4034-4049. https://doi.org/10.1364/BOE.10.004034

APA

Fang, Q., Krajancich, B., Chin, L., Zilkens, R., Curatolo, A., Frewer, L., ... Kennedy, B. F. (2019). Handheld probe for quantitative micro-elastography. Biomedical Optics Express, 10(8), 4034-4049. https://doi.org/10.1364/BOE.10.004034

Vancouver

Fang Q, Krajancich B, Chin L, Zilkens R, Curatolo A, Frewer L et al. Handheld probe for quantitative micro-elastography. Biomedical Optics Express. 2019 Aug 1;10(8):4034-4049. https://doi.org/10.1364/BOE.10.004034

Author

Fang, Qi ; Krajancich, Brooke ; Chin, Lixin ; Zilkens, Renate ; Curatolo, Andrea ; Frewer, Luke ; Anstie, James D. ; Wijesinghe, Philip ; Hall, Colin ; Dessauvagie, Benjamin F. ; Latham, Bruce ; Saunders, Christobel M. ; Kennedy, Brendan F. / Handheld probe for quantitative micro-elastography. In: Biomedical Optics Express. 2019 ; Vol. 10, No. 8. pp. 4034-4049.

Bibtex - Download

@article{41417d87792647f58724a0cf54d046f0,
title = "Handheld probe for quantitative micro-elastography",
abstract = "Optical coherence elastography (OCE) has been proposed for a range of clinical applications. However, the majority of these studies have been performed using bulks, lab based imaging systems. A compact. handheld imaging probe would accelerate clinical translation, however, to date. tins had been inhibited by the slow scan rates of compact devices and the motion artifact induced by the user's hand. In this paper, we present a proof-of-concept. handheld quantitative micro-elastography (QME) probe capable of scanning a 6 x 6 x 1 mm volume of tissue in 3.4 seconds. This handheld probe is enabled by a novel QME acquisition protocol that incorporates a custom bidirectional scan pattern driving a microelectromechanical system (MEMS) scanner, synchronized with the sample deformation induced by an annular PZT actuator. The custom scan pattern reduces the total acquisition time and the time difference between B-scans used to generate displacement maps. minimizing the impact of motion artifact. We test the feasibility of the handheld QME probe on a tissue-mimicking silicone phantom, demonstrating comparable image quality to a bench-mounted setup. In addition, we present the first handheld QME scans performed on human breast tissue specimens. For each specimen, quantitative micro-elastograms are co-registered with, and validated by, histology, demonstrating the ability-to distinguish stiff cancerous tissue from surrounding soft benign tissue.",
author = "Qi Fang and Brooke Krajancich and Lixin Chin and Renate Zilkens and Andrea Curatolo and Luke Frewer and Anstie, {James D.} and Philip Wijesinghe and Colin Hall and Dessauvagie, {Benjamin F.} and Bruce Latham and Saunders, {Christobel M.} and Kennedy, {Brendan F.}",
note = "Funding: Australian Research Council (ARC); Department of Health, Western Australia; Cancer Council, Western Australia; OncoRes Medical.",
year = "2019",
month = "8",
day = "1",
doi = "10.1364/BOE.10.004034",
language = "English",
volume = "10",
pages = "4034--4049",
journal = "Biomedical Optics Express",
issn = "2156-7085",
publisher = "OPTICAL SOC AMER",
number = "8",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Handheld probe for quantitative micro-elastography

AU - Fang, Qi

AU - Krajancich, Brooke

AU - Chin, Lixin

AU - Zilkens, Renate

AU - Curatolo, Andrea

AU - Frewer, Luke

AU - Anstie, James D.

AU - Wijesinghe, Philip

AU - Hall, Colin

AU - Dessauvagie, Benjamin F.

AU - Latham, Bruce

AU - Saunders, Christobel M.

AU - Kennedy, Brendan F.

N1 - Funding: Australian Research Council (ARC); Department of Health, Western Australia; Cancer Council, Western Australia; OncoRes Medical.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Optical coherence elastography (OCE) has been proposed for a range of clinical applications. However, the majority of these studies have been performed using bulks, lab based imaging systems. A compact. handheld imaging probe would accelerate clinical translation, however, to date. tins had been inhibited by the slow scan rates of compact devices and the motion artifact induced by the user's hand. In this paper, we present a proof-of-concept. handheld quantitative micro-elastography (QME) probe capable of scanning a 6 x 6 x 1 mm volume of tissue in 3.4 seconds. This handheld probe is enabled by a novel QME acquisition protocol that incorporates a custom bidirectional scan pattern driving a microelectromechanical system (MEMS) scanner, synchronized with the sample deformation induced by an annular PZT actuator. The custom scan pattern reduces the total acquisition time and the time difference between B-scans used to generate displacement maps. minimizing the impact of motion artifact. We test the feasibility of the handheld QME probe on a tissue-mimicking silicone phantom, demonstrating comparable image quality to a bench-mounted setup. In addition, we present the first handheld QME scans performed on human breast tissue specimens. For each specimen, quantitative micro-elastograms are co-registered with, and validated by, histology, demonstrating the ability-to distinguish stiff cancerous tissue from surrounding soft benign tissue.

AB - Optical coherence elastography (OCE) has been proposed for a range of clinical applications. However, the majority of these studies have been performed using bulks, lab based imaging systems. A compact. handheld imaging probe would accelerate clinical translation, however, to date. tins had been inhibited by the slow scan rates of compact devices and the motion artifact induced by the user's hand. In this paper, we present a proof-of-concept. handheld quantitative micro-elastography (QME) probe capable of scanning a 6 x 6 x 1 mm volume of tissue in 3.4 seconds. This handheld probe is enabled by a novel QME acquisition protocol that incorporates a custom bidirectional scan pattern driving a microelectromechanical system (MEMS) scanner, synchronized with the sample deformation induced by an annular PZT actuator. The custom scan pattern reduces the total acquisition time and the time difference between B-scans used to generate displacement maps. minimizing the impact of motion artifact. We test the feasibility of the handheld QME probe on a tissue-mimicking silicone phantom, demonstrating comparable image quality to a bench-mounted setup. In addition, we present the first handheld QME scans performed on human breast tissue specimens. For each specimen, quantitative micro-elastograms are co-registered with, and validated by, histology, demonstrating the ability-to distinguish stiff cancerous tissue from surrounding soft benign tissue.

U2 - 10.1364/BOE.10.004034

DO - 10.1364/BOE.10.004034

M3 - Article

VL - 10

SP - 4034

EP - 4049

JO - Biomedical Optics Express

JF - Biomedical Optics Express

SN - 2156-7085

IS - 8

ER -

Related by author

  1. Optimal compressive multiphoton imaging at depth using single-pixel detection

    Wijesinghe, P., Escobet Montalban, A., Chen, M., Munro, P. R. T. & Dholakia, K., 15 Oct 2019, In : Optics Letters. 44, 20, p. 4981-4984 4 p.

    Research output: Contribution to journalLetter

  2. Finger-mounted quantitative micro-elastography

    Sanderson, R. W., Curatolo, A., Wijesinghe, P., Chin, L. & Kennedy, B. F., 1 Apr 2019, In : Biomedical Optics Express. 10, 4, p. 1760-1773 14 p.

    Research output: Contribution to journalArticle

  3. Analysis of spatial resolution in phase-sensitive compression optical coherence elastography

    Hepburn, M. S., Wijesinghe, P., Chin, L. & Kennedy, B. F., 28 Feb 2019, In : Biomedical Optics Express. 10, 3, p. 1496-1513 18 p.

    Research output: Contribution to journalArticle

  4. Wide-field multiphoton imaging with TRAFIX

    Escobet-Montalbán, A., Wijesinghe, P., Chen, M. & Dholakia, K., 22 Feb 2019, Multiphoton Microscopy in the Biomedical Sciences XIX. Periasamy, A., So, P. T. C. & König, K. (eds.). Society of Photo-Optical Instrumentation Engineers, p. 49 9 p. 10882G. (Proceedings of SPIE; vol. 10882).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  5. Light sheet microscopy with acoustic sample confinement

    Yang, Z., Cole, K. L. H., Qiu, Y., Somorjai, I. M. L., Wijesinghe, P., Nylk, J., Cochran, S., Spalding, G. C., Lyons, D. A. & Dholakia, K., 8 Feb 2019, In : Nature Communications. 10, 8 p., 669.

    Research output: Contribution to journalArticle

Related by journal

  1. Analysis of spatial resolution in phase-sensitive compression optical coherence elastography

    Hepburn, M. S., Wijesinghe, P., Chin, L. & Kennedy, B. F., 28 Feb 2019, In : Biomedical Optics Express. 10, 3, p. 1496-1513 18 p.

    Research output: Contribution to journalArticle

  2. Finger-mounted quantitative micro-elastography

    Sanderson, R. W., Curatolo, A., Wijesinghe, P., Chin, L. & Kennedy, B. F., 1 Apr 2019, In : Biomedical Optics Express. 10, 4, p. 1760-1773 14 p.

    Research output: Contribution to journalArticle

  3. Fast volume-scanning light sheet microscopy reveals transient neuronal events

    Haslehurst, P., Yang, Z., Dholakia, K. & Emptage, N., 1 May 2018, In : Biomedical Optics Express. 9, 5, p. 2154-2167

    Research output: Contribution to journalArticle

  4. Multimode fibre based imaging for optically cleared samples

    Gusachenko, I., Nylk, J., Tello, J. A. & Dholakia, K., 1 Nov 2017, In : Biomedical Optics Express. 8, 11, p. 5179-5190

    Research output: Contribution to journalArticle

ID: 260598099

Top