Skip to content

Research at St Andrews

Histone tails and the H3 alpha N helix regulate nucleosome mobility and stability

Research output: Research - peer-reviewArticle

DOI

Author(s)

Helder Ferreira, Joanna Somers, Ryan Webster, Andrew Flaus, Tom Owen-Hughes

School/Research organisations

Abstract

Nucleosomes fulfill the apparently conflicting roles of compacting DNA within eukaryotic genomes while permitting access to regulatory factors. Central to this is their ability to stably associate with DNA while retaining the ability to undergo rearrangements that increase access to the underlying DNA. Here, we have studied different aspects of nucleosome dynamics including nucleosome sliding, histone dimer exchange, and DNA wrapping within nucleosomes. We find that alterations to histone proteins, especially the histone tails and vicinity of the histone H3 alpha N helix, can affect these processes differently, suggesting that they are mechanistically distinct. This raises the possibility that modifications to histone proteins may provide a means of fine-tuning specific aspects of the dynamic properties of nucleosomes to the context in which they are located.

Close

Details

Original languageEnglish
Pages (from-to)4037-4048
Number of pages12
JournalMolecular and Cellular Biology
Volume27
Issue number11
DOIs
StatePublished - Jun 2007

    Research areas

  • BASE-PAIR RESOLUTION, SACCHAROMYCES-CEREVISIAE, CORE PARTICLE, LINKER DNA, POSTTRANSLATIONAL MODIFICATIONS, LYSINE-56 ACETYLATION, ANGSTROM RESOLUTION, TERMINAL TAILS, CHROMATIN, TRANSCRIPTION

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. The shelterin protein POT-1 anchors Caenorhabditis elegans telomeres through SUN-1 at the nuclear periphery

    Ferreira, H. C., Towbin, B. D., Jegou, T. & Gasser, S. M. 9 Dec 2013 In : Journal of Cell Biology. 203, 5, p. 727-735 9 p.

    Research output: Research - peer-reviewArticle

  2. Regulating repression: roles for the Sir4 N-terminus in linker DNA protection and stabilization of epigenetic states

    Kueng, S., Tsai-Pflugfelder, M., Oppikofer, M., Ferreira, H. C., Roberts, E., Tsai, C., Roloff, T-C., Sack, R. & Gasser, S. M. May 2012 In : PLoS Genetics. 8, 5, 19 p., e1002727

    Research output: Research - peer-reviewArticle

  3. The PIAS homologue Siz2 regulates perinuclear telomere position and telomerase activity in budding yeast

    Ferreira, H. C., Luke, B., Schober, H., Kalck, V., Lingner, J. & Gasser, S. M. Jul 2011 In : Nature Cell Biology. 13, 7, p. 867-874

    Research output: Research - peer-reviewArticle

  4. Yeast telomerase and the SUN domain protein Mps3 anchor telomeres and repress subtelomeric recombination

    Schober, H., Ferreira, H. C., Kalck, R., Gehlen, L. R. & Gasser, S. M. 15 Apr 2009 In : Genes & Development. 23, 8, p. 928-938 11 p.

    Research output: Research - peer-reviewArticle

  5. MacroH2A Allows ATP-Dependent Chromatin Remodeling by SWI/SNF and ACF Complexes but Specifically Reduces Recruitment of SWI/SNF

    Chang, E. Y., Ferreira, H., Somers, J., Nusinow, D. A., Owen-Hughes, T. & Narlikar, G. J. 23 Dec 2008 In : Biochemistry. 47, 51, p. 13726-13732 7 p.

    Research output: Research - peer-reviewArticle

Related by journal

  1. Site-specific release of nascent chains from ribosomes at a sense codon

    Doronina, V. A., Wu, C., De Felipe, P., Sachs, M. S., Ryan, M. D. & Brown, J. D. Jul 2008 In : Molecular and Cellular Biology. 28, 13, p. 4227-4239 13 p.

    Research output: Research - peer-reviewArticle

  2. Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance

    Bayascas, J. R., Wullschleger, S., Sakamoto, K., Garcia-Martinez, J. M., Clacher, C., Komander, D., van Aalten, D. M. F., Boini, K. M., Lang, F., Lipina, C., Logie, L., Sutherland, C., Chudek, J. A., van Diepen, J. A., Voshol, P. J., Lucocq, J. M. & Alessi, D. R. May 2008 In : Molecular and Cellular Biology. 28, 10, p. 3258-3272 15 p.

    Research output: Research - peer-reviewArticle

  3. Dynamic regulation of histone modifications in Xenopus oocytes through histone exchange.

    Stewart, M. D., Sommerville, J. & Wong, J. Sep 2006 In : Molecular and Cellular Biology. 26, 18, p. 6890-6901 12 p.

    Research output: Research - peer-reviewArticle

ID: 72683302