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Human infections with Plasmodium knowlesi - zoonotic malaria

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Human infections with Plasmodium knowlesi - zoonotic malaria. / Millar, S B; Cox Singh, Janet.

In: Clinical Microbiology and Infection, Vol. 21, No. 7, 07.2015, p. 640-648.

Research output: Contribution to journalArticle

Harvard

Millar, SB & Cox Singh, J 2015, 'Human infections with Plasmodium knowlesi - zoonotic malaria', Clinical Microbiology and Infection, vol. 21, no. 7, pp. 640-648. https://doi.org/10.1016/j.cmi.2015.03.017

APA

Millar, S. B., & Cox Singh, J. (2015). Human infections with Plasmodium knowlesi - zoonotic malaria. Clinical Microbiology and Infection, 21(7), 640-648. https://doi.org/10.1016/j.cmi.2015.03.017

Vancouver

Millar SB, Cox Singh J. Human infections with Plasmodium knowlesi - zoonotic malaria. Clinical Microbiology and Infection. 2015 Jul;21(7):640-648. https://doi.org/10.1016/j.cmi.2015.03.017

Author

Millar, S B ; Cox Singh, Janet. / Human infections with Plasmodium knowlesi - zoonotic malaria. In: Clinical Microbiology and Infection. 2015 ; Vol. 21, No. 7. pp. 640-648.

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@article{b1c2aaef277649a59fcd8137a63b8900,
title = "Human infections with Plasmodium knowlesi - zoonotic malaria",
abstract = "In 2004 a large focus of Plasmodium knowlesi malaria was reported in the human population in Sarawak, Malaysian Borneo. Plasmodium knowlesi, a parasite of the South-East Asian macaques (Macaca fascicularis and Macaca nemestrina), had entered the human population. Plasmodium knowlesi is transmitted by the leucosphyrus group of Anopheline mosquitoes and transmission is largely zoonotic and restricted to the jungle setting. Humans entering jungle transmission sites are at risk. Since 2004, human cases of P. knowlesi have been continuously reported in local communities and in travellers returning from South East Asia. Plasmodium knowlesi is the most common type of indigenous malaria reported in Malaysia. Infections are most often uncomplicated but at least 10{\%} of patients report with severe malaria and 1-2{\%} of cases have a fatal outcome. Parasitaemia is positively associated with the clinical and laboratory markers of severe malaria. The current literature on P. knowlesi, including epidemiology, natural hosts and vectors, pathogenesis, clinical descriptions, treatment and diagnosis, is reviewed. There are many gaps in our understanding of this disease that are highlighted here with suggestions for further research to inform pre-emptive control measures that would be required to prevent a full emergence of this parasite into the human population.",
keywords = "Diagnosis, Epidemiology, Malaria, Pathogenesis, Plasmodium knowlesi",
author = "Millar, {S B} and {Cox Singh}, Janet",
note = "Date of Acceptance:",
year = "2015",
month = "7",
doi = "10.1016/j.cmi.2015.03.017",
language = "English",
volume = "21",
pages = "640--648",
journal = "Clinical Microbiology and Infection",
issn = "1198-743X",
publisher = "Blackwell",
number = "7",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Human infections with Plasmodium knowlesi - zoonotic malaria

AU - Millar, S B

AU - Cox Singh, Janet

N1 - Date of Acceptance:

PY - 2015/7

Y1 - 2015/7

N2 - In 2004 a large focus of Plasmodium knowlesi malaria was reported in the human population in Sarawak, Malaysian Borneo. Plasmodium knowlesi, a parasite of the South-East Asian macaques (Macaca fascicularis and Macaca nemestrina), had entered the human population. Plasmodium knowlesi is transmitted by the leucosphyrus group of Anopheline mosquitoes and transmission is largely zoonotic and restricted to the jungle setting. Humans entering jungle transmission sites are at risk. Since 2004, human cases of P. knowlesi have been continuously reported in local communities and in travellers returning from South East Asia. Plasmodium knowlesi is the most common type of indigenous malaria reported in Malaysia. Infections are most often uncomplicated but at least 10% of patients report with severe malaria and 1-2% of cases have a fatal outcome. Parasitaemia is positively associated with the clinical and laboratory markers of severe malaria. The current literature on P. knowlesi, including epidemiology, natural hosts and vectors, pathogenesis, clinical descriptions, treatment and diagnosis, is reviewed. There are many gaps in our understanding of this disease that are highlighted here with suggestions for further research to inform pre-emptive control measures that would be required to prevent a full emergence of this parasite into the human population.

AB - In 2004 a large focus of Plasmodium knowlesi malaria was reported in the human population in Sarawak, Malaysian Borneo. Plasmodium knowlesi, a parasite of the South-East Asian macaques (Macaca fascicularis and Macaca nemestrina), had entered the human population. Plasmodium knowlesi is transmitted by the leucosphyrus group of Anopheline mosquitoes and transmission is largely zoonotic and restricted to the jungle setting. Humans entering jungle transmission sites are at risk. Since 2004, human cases of P. knowlesi have been continuously reported in local communities and in travellers returning from South East Asia. Plasmodium knowlesi is the most common type of indigenous malaria reported in Malaysia. Infections are most often uncomplicated but at least 10% of patients report with severe malaria and 1-2% of cases have a fatal outcome. Parasitaemia is positively associated with the clinical and laboratory markers of severe malaria. The current literature on P. knowlesi, including epidemiology, natural hosts and vectors, pathogenesis, clinical descriptions, treatment and diagnosis, is reviewed. There are many gaps in our understanding of this disease that are highlighted here with suggestions for further research to inform pre-emptive control measures that would be required to prevent a full emergence of this parasite into the human population.

KW - Diagnosis

KW - Epidemiology

KW - Malaria

KW - Pathogenesis

KW - Plasmodium knowlesi

U2 - 10.1016/j.cmi.2015.03.017

DO - 10.1016/j.cmi.2015.03.017

M3 - Article

VL - 21

SP - 640

EP - 648

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

SN - 1198-743X

IS - 7

ER -

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