Skip to content

Research at St Andrews

Incorporation of cisplatin into the metal-organic frameworks UiO66-NH2 and UiO66 – encapsulation vs. conjugation.

Research output: Contribution to journalArticlepeer-review


Open Access permissions



Katarzyna Anna Mocniak, Ilona Kubajewska, Dominic E.M. Spillane, Gareth R. Williams, Russell Edward Morris

School/Research organisations


This work demonstrates synthetic strategies for the incorporation of an anticancer drug, cisplatin, and a Pt(IV) cisplatin prodrug into two zirconium-based metal-organic-frameworks (MOFs): UiO66 and UiO66-NH2. Cisplatin was chosen due to its reported high potency in killing ca. 95% of different cancers. Two approaches for its incorporation were investigated: conjugation and encapsulation. In the conjugation route, a Pt(IV) cisplatin prodrug was incorporated into UiO66-NH2 utilising its amine group in an amide-coupling reaction. In the second case, cisplatin was encapsulated into the large cavities of both MOFs. The presence of platinum was confirmed by energy-dispersive X-ray spectroscopy and microwave plasma-atomic emission spectroscopy. The cytotoxicity of the formulations was assessed on the A549 lung cancer cell line. The results show that the system in which cisplatin is conjugated to UiO66-NH2 is more efficient in inducing cell death than the materials where cisplatin is encapsulated into the pores of the MOFs. This is consistent with the higher drug loading achieved with the conjugation technique. One disadvantage of cisplatin therapy is that it may lead to thrombosis and, as a consequence, to heart attack and cardiac arrest. To ameliorate this potential side effect, we investigated the incorporation of NO (which has been widely researched for its antithrombotic properties) into the drug-loaded MOFs. All the cisplatin or pro-drug loaded MOFs are able to entrap and then release NO. Furthermore, the amount of NO released from these formulations is much greater than from the pure MOFs. As a result, the drug delivery systems developed in this work have potentially potent double functionality.



Original languageEnglish
Pages (from-to)83648-83656
Number of pages9
JournalRSC Advances
Issue number102
Early online date25 Sep 2015
Publication statusPublished - 2015

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. Reverse ADOR: reconstruction of UTL zeolite from layered IPC-1P

    Veselý, O., Eliášová, P., Morris, R. E. & Čejka, J., 2 Apr 2021, In: Materials Advances. Advance Article

    Research output: Contribution to journalArticlepeer-review

  2. Controlled synthesis of large single crystals of metal-organic framework CPO-27-Ni prepared by a modulation approach: in situ single crystal X-ray diffraction studies

    Vornholt, S. M., Elliott, C., Rice, C. M., Russell, S. E., Kerr, P. J., Rainer, D. N., Mazur, M., Warren, M. R., Wheatley, P. S. & Morris, R. E., 29 Mar 2021, (Accepted/In press) In: Chemistry - A European Journal. In press, 11 p.

    Research output: Contribution to journalArticlepeer-review

  3. 17O NMR spectroscopy of crystalline microporous materials

    Ashbrook, S. E., Davis, Z., Morris, R. & Rice, C. M., 25 Feb 2021, In: Chemical Science. Advance Article, 21 p.

    Research output: Contribution to journalReview articlepeer-review

  4. Multifaceted study of the interactions between CPO-27-Ni and polyurethane and their impact on nitric oxide release performance

    Vornholt, S. M., Duncan, M. J., Warrender, S. J., Semino, R., Ramsahye, N. A., Maurin, G., Smith, M. W., Tan, J-C., Miller, D. N. & Morris, R. E., 30 Dec 2020, In: ACS Applied Materials & Interfaces. 12, 52, p. 58263-58276

    Research output: Contribution to journalArticlepeer-review

  5. Antibacterial efficacy from NO-releasing MOF–polymer films

    Duncan, M. J., Wheatley, P. S., Coghill, E. M., Vornholt, S. M., Warrender, S. J., Megson, I. L. & Morris, R. E., 7 Oct 2020, In: Materials Advances. 1, 7, p. 2509-2519 11 p.

    Research output: Contribution to journalArticlepeer-review

Related by journal

  1. Isolation of 5′-O-sulfamyladenosine and related 3′-O-β-glucosylated adenosines from the nucleocidin producer Streptomyces calvus

    Feng, X., Bello, D. & O'Hagan, D., 28 Jan 2021, In: RSC Advances. 11, 10, p. 5291-5294 4 p.

    Research output: Contribution to journalArticlepeer-review

  2. Conversion of a microwave synthesized alkali-metal MOF to carbonaceous anode for Li-ion batteries

    Desai, A. V., Pereira Pimenta, V. J., King, C., Cordes, D. B., Slawin, A. M. Z., Morris, R. E. & Armstrong, R., 2020, In: RSC Advances. 10, 23, p. 13732-13736

    Research output: Contribution to journalArticlepeer-review

  3. Elastic distortion determining conduction in BiFeO3 phase boundaries

    Holsgrove, K. M., Duchamp, M., Moreno, M. S., Bernier, N., Naden, A. B., Guy, J. G. M., Browne, N., Gupta, A., Gregg, J. M., Kumar, A. & Arredondo, M., 27 Jul 2020, In: RSC Advances. 10, 47, p. 27954-27960 7 p.

    Research output: Contribution to journalArticlepeer-review

  4. Reducing toxic reactive carbonyl species in e-cigarette emissions: testing a harm-reduction strategy based on dicarbonyl trapping

    de Falco, B., Petridis, A., Paramasivan, P., Troise, A. D., Scaloni, A., Deeni, Y., Stephens, W. E. & Fiore, A., 5 Jun 2020, In: RSC Advances. 10, 36, p. 21535-21544 10 p.

    Research output: Contribution to journalArticlepeer-review

  5. Synthesis, study of antileishmanial and antitrypanosomal activity of imidazo pyridine fused triazole analogues

    Nandikolla, A., Srinivasarao, S., Karan Kumar, B., Murugesan, S., Aggarwal, H., Major, L. L., Smith, T. K. & Chandra Sekhar, K. V. G., 19 Oct 2020, In: RSC Advances. 10, 63, p. 38328-38343 16 p.

    Research output: Contribution to journalArticlepeer-review

ID: 221674653