Skip to content

Research at St Andrews

Insights into the catalytic activity of [Pd(NHC)(cin)Cl] (NHC = IPr, IPrCl, IPrBr) complexes in the Suzuki-Miyaura reaction

Research output: Contribution to journalArticle


Frederic Izquierdo, Caroline Zinser, Yury Minenkov, David Cordes, Alexandra Slawin, Luigi Cavallo, Fady Nahra, Catherine Cazin, Steven Patrick Nolan

School/Research organisations


The influence of C4,5-halogenation on palladium N-heterocyclic carbene complexes and their activity in the Suzuki-Miyaura reaction have been investigated. Two [Pd(NHC)(cin)Cl] complexes bearing IPrCl and IPrBr ligands were synthesized. After determining electronic and steric properties of these ligands, their properties were compared to those of [Pd(IPr)(cin)Cl]. The three palladium complexes were studied using DFT calculations to delineate their behaviour in the activation step leading to the putative 12-electron active catalyst. Experimentally, their catalytic activity in the Suzuki-Miyaura reaction involving a wide range of coupling partners (30 entries) at low catalyst loading was studied.


Original languageEnglish
Pages (from-to)601-611
Issue number3
Early online date19 Dec 2017
Publication statusPublished - 7 Feb 2018

    Research areas

  • Catalysis, NHC, Palladium, Suzuki-Miyaura, DFT

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

Related by journal

  1. Selective depolymerisation of γ-oxidised lignin via NHC catalysed redox esterification

    Xiao, G., Lancefield, C. & Westwood, N. J., 11 Jun 2019, In : ChemCatChem. Early View

    Research output: Contribution to journalArticle

  2. Covalently immobilized lipase on a thermoresponsive polymer with an upper critical solution temperature as an efficient and recyclable asymmetric catalyst in aqueous media

    Lou, L-L., Qu, H., Yu, W., Wang, B., Ouyang, L., Liu, S. & Zhou, W., 7 Mar 2018, In : ChemCatChem. 10, 5, p. 1166-1172

    Research output: Contribution to journalArticle

  3. Gold-N-Heterocyclic Carbene Complexes of Mineral Acids

    Brill, M., Nahra, F., Gomez-Herrera, A., Zinser, C., Cordes, D. B., Slawin, A. M. Z. & Nolan, S. P., 12 Jan 2017, In : ChemCatChem. 9, 1, p. 117-120 4 p.

    Research output: Contribution to journalArticle

ID: 251138591