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Insights into the mechanism of the cyanobactin heterocyclase enzyme

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  1. An internal thioester in a pathogen surface protein mediates covalent host binding

    Walden, M., Edwards, J. M., Dziewulska, A. M., Bergmann, R., Saalbach, G., Kan, S-Y., Miller, O. K., Weckener, M., Jackson, R. J., Shirran, S. L., Botting, C. H., Florence, G. J., Rohde, M., Banfield, M. J. & Schwarz-Linek, U., 2 Jun 2015, In : eLife. 4, 24 p., e06638.

    Research output: Contribution to journalArticle

  2. The cyanobactin heterocyclase enzyme: A processive adenylase that operates with a defined order of reaction

    Koehnke, J. A. J. G., Bent, A. F., Zollman, D., Smith, K., Houssen, W. E., Zhu, X., Mann, G., Lebl, T., Scharff, R., Shirran, S. L., Botting, C. H., Jaspers, M., Schwarz-Linek, U. & Naismith, J., Dec 2013, In : Angewandte Chemie International Edition. 52, 52, p. 13991-13996 7 p.

    Research output: Contribution to journalArticle

  3. The Scottish Structural Proteomics Facility: targets, methods and outputs

    Oke, M., Carter, LG., Johnson, KA., Liu, H., McMahon, SA., Yan, X., Kerou, M., Weikart, ND., Kadi, N., Sheikh, MA., Schmelz, S., Dorward, M., Zawadzki, M., Cozens, C., Falconer, H., Powers, H., Overton, IM., van Niekerk, CA., Peng, X., Patel, P. & 11 others, Garrett, RA., Prangishvili, D., Botting, CH., Coote, PJ., Dryden, DT., Barton, GJ., Schwarz-Linek, U., Challis, GL., Taylor, GL., White, MF. & Naismith, JH., 1 Jun 2010, In : Journal of Structural and Functional Genomics. 11, 2, p. 167-180

    Research output: Contribution to journalArticle

  4. CC1, a novel crenarchaeal DNA binding protein

    Luo, X., Schwarz-Linek, U., Botting, C. H., Hensel, R., Siebers, B. & White, M. F., Jan 2007, In : Journal of Bacteriology. 189, p. 403-409 7 p.

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  1. An exceptionally potent inhibitor of human CD73

    Bowman, C. E., da Silva, R. G., Pham, A. & Young, S. W., 6 Aug 2019, In : Biochemistry. 58, 31, p. 3331-3334 4 p.

    Research output: Contribution to journalArticle

  2. Mapping the structural path for allosteric inhibition of a short-form ATP phosphoribosyltransferase by histidine

    Thomson, C. M., Alphey, M. S., Fisher, G. & da Silva, R. G., 16 Jul 2019, In : Biochemistry. 58, 28, p. 3078-3086

    Research output: Contribution to journalArticle

  3. Allosteric activation shifts the rate-limiting step in a short-form ATP phosphoribosyltransferase

    Fisher, G., Thomson, C. M., Stroek, R., Czekster, C. M., Hirschi, J. S. & da Silva, R. G., 24 Jul 2018, In : Biochemistry. 57, 29, p. 4357-4367

    Research output: Contribution to journalArticle

  4. Linear Eyring plots conceal a change in rate-limiting step in an enzyme reaction

    Machado, T. F. G., Gloster, T. & da Silva, R. G., 11 Dec 2018, In : Biochemistry. 57, 49, p. 6757-6761

    Research output: Contribution to journalArticle

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