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Invertebrate extracellular phagocyte traps show that chromatin is an ancient defence weapon

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Invertebrate extracellular phagocyte traps show that chromatin is an ancient defence weapon. / Robb, Calum; Dyrynda, Elisabeth; Gray, Robert; Rossi, Adriano; Smith, Valerie Jane.

In: Nature Communications, Vol. 5, 4627, 13.08.2014.

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Robb, C, Dyrynda, E, Gray, R, Rossi, A & Smith, VJ 2014, 'Invertebrate extracellular phagocyte traps show that chromatin is an ancient defence weapon' Nature Communications, vol. 5, 4627. https://doi.org/10.1038/ncomms5627

APA

Robb, C., Dyrynda, E., Gray, R., Rossi, A., & Smith, V. J. (2014). Invertebrate extracellular phagocyte traps show that chromatin is an ancient defence weapon. Nature Communications, 5, [4627]. https://doi.org/10.1038/ncomms5627

Vancouver

Robb C, Dyrynda E, Gray R, Rossi A, Smith VJ. Invertebrate extracellular phagocyte traps show that chromatin is an ancient defence weapon. Nature Communications. 2014 Aug 13;5. 4627. https://doi.org/10.1038/ncomms5627

Author

Robb, Calum ; Dyrynda, Elisabeth ; Gray, Robert ; Rossi, Adriano ; Smith, Valerie Jane. / Invertebrate extracellular phagocyte traps show that chromatin is an ancient defence weapon. In: Nature Communications. 2014 ; Vol. 5.

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@article{73ccf1afe078467c92e2b743c8457ba0,
title = "Invertebrate extracellular phagocyte traps show that chromatin is an ancient defence weapon",
abstract = "Controlled release of chromatin from the nuclei ofinflammatory cells is a process that entraps and killsmicroorganisms in the extracellular environment. Now termedETosis, it is important in innate immunity in vertebrates.Paradoxically, however, in mammals it can also contribute tocertain pathologies. Here we show that ETosis occurs in severalinvertebrate species, including, remarkably, an acoelomate.Our findings reveal that the phenomenon is primordial andpredates the evolution of the coelom. In invertebrates thereleased chromatin participates in defence not only byensnaring microorganisms and externalising antibacterialhistones together with other haemocyte-derived defencefactors, but crucially, also provides the scaffold upon whichintact haemocytes assemble during encapsulation; a responsethat sequesters and kills potential pathogens infecting the bodycavity. This insight into the early origin of ETosis identifies it asa very ancient process that helps explain some of itsdetrimental effects in mammals.",
author = "Calum Robb and Elisabeth Dyrynda and Robert Gray and Adriano Rossi and Smith, {Valerie Jane}",
year = "2014",
month = "8",
day = "13",
doi = "10.1038/ncomms5627",
language = "English",
volume = "5",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature publishing group",

}

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TY - JOUR

T1 - Invertebrate extracellular phagocyte traps show that chromatin is an ancient defence weapon

AU - Robb, Calum

AU - Dyrynda, Elisabeth

AU - Gray, Robert

AU - Rossi, Adriano

AU - Smith, Valerie Jane

PY - 2014/8/13

Y1 - 2014/8/13

N2 - Controlled release of chromatin from the nuclei ofinflammatory cells is a process that entraps and killsmicroorganisms in the extracellular environment. Now termedETosis, it is important in innate immunity in vertebrates.Paradoxically, however, in mammals it can also contribute tocertain pathologies. Here we show that ETosis occurs in severalinvertebrate species, including, remarkably, an acoelomate.Our findings reveal that the phenomenon is primordial andpredates the evolution of the coelom. In invertebrates thereleased chromatin participates in defence not only byensnaring microorganisms and externalising antibacterialhistones together with other haemocyte-derived defencefactors, but crucially, also provides the scaffold upon whichintact haemocytes assemble during encapsulation; a responsethat sequesters and kills potential pathogens infecting the bodycavity. This insight into the early origin of ETosis identifies it asa very ancient process that helps explain some of itsdetrimental effects in mammals.

AB - Controlled release of chromatin from the nuclei ofinflammatory cells is a process that entraps and killsmicroorganisms in the extracellular environment. Now termedETosis, it is important in innate immunity in vertebrates.Paradoxically, however, in mammals it can also contribute tocertain pathologies. Here we show that ETosis occurs in severalinvertebrate species, including, remarkably, an acoelomate.Our findings reveal that the phenomenon is primordial andpredates the evolution of the coelom. In invertebrates thereleased chromatin participates in defence not only byensnaring microorganisms and externalising antibacterialhistones together with other haemocyte-derived defencefactors, but crucially, also provides the scaffold upon whichintact haemocytes assemble during encapsulation; a responsethat sequesters and kills potential pathogens infecting the bodycavity. This insight into the early origin of ETosis identifies it asa very ancient process that helps explain some of itsdetrimental effects in mammals.

U2 - 10.1038/ncomms5627

DO - 10.1038/ncomms5627

M3 - Article

VL - 5

JO - Nature Communications

T2 - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 4627

ER -

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ID: 150656653