Skip to content

Research at St Andrews

Iron-sulphur clusters in nucleic acid processing enzymes

Research output: Contribution to journalArticlepeer-review

Author(s)

Malcolm F. White, Mark S. Dillingham

School/Research organisations

Abstract

Several unexpected reports of iron-sulphur clusters in nucleic acid binding proteins have recently appeared in the literature. Once thought to be relatively rare in these systems, iron-sulphur clusters are now known to be essential components of diverse nucleic acid processing machinery including glycosylases, primases, helicases, nucleases, transcription factors, RNA polymerases and RNA methyltransferases. In many cases, the function of the cluster is poorly understood and crystal structures of these iron-sulphur enzymes reveal little in common between them. In this article, we review the recent developments in the field and discuss to what extent there might exist common mechanistic roles for iron-sulphur clusters in nucleic acid enzymes.

Close

Details

Original languageEnglish
Pages (from-to)94-100
Number of pages7
JournalCurrent Opinion in Structural Biology
Volume22
Issue number1
DOIs
Publication statusPublished - Feb 2012

Discover related content
Find related publications, people, projects and more using interactive charts.

View graph of relations

Related by author

  1. The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence

    Zhu, W., McQuarrie, S. J., Gruschow, S., McMahon, S., Graham, S., Gloster, T. & White, M., 15 Feb 2021, In: Nucleic Acids Research. Advance Article, 13 p., gkab073.

    Research output: Contribution to journalArticlepeer-review

  2. Facile and scalable expression and purification of transcription factor IIH (TFIIH) core complex

    Sanles-Falagan, R., Petrovic-Stojanovska, B. & White, M. F., Oct 2020, In: Protein Expression and Purification. 174, 105660.

    Research output: Contribution to journalArticlepeer-review

  3. Tetramerisation of the CRISPR ring nuclease Crn3/Csx3 facilitates cyclic oligoadenylate cleavage

    Athukoralage, J. S., McQuarrie, S. J., Gruschow, S., Graham, S., Gloster, T. & White, M., 20 Jul 2020, In: eLife. 9, 19 p., e57627.

    Research output: Contribution to journalArticlepeer-review

  4. Bacteria SAVED from viruses

    White, M. F., 9 Jul 2020, In: Cell. 182, 1, p. 5-6 2 p.

    Research output: Contribution to journalArticlepeer-review

  5. Fuse to defuse: a self-limiting ribonuclease-ring nuclease fusion for type III CRISPR defence

    Samolygo, A., Athukoralage, J. S., Graham, S. & White, M., 19 Jun 2020, In: Nucleic Acids Research. 48, 11, p. 6149–6156 8 p.

    Research output: Contribution to journalArticlepeer-review

Related by journal

  1. Halogenases: structures and functions

    Ludewig, H., Molyneux, S., Ferrinho, S., Guo, K., Lynch, R., Gkotsi, D. S. & Goss, R. JM., Dec 2020, In: Current Opinion in Structural Biology. 65, p. 51-60 10 p.

    Research output: Contribution to journalReview articlepeer-review

  2. Enzyme function and its evolution

    Mitchell, J. B. O., Dec 2017, In: Current Opinion in Structural Biology. 47, p. 151-156

    Research output: Contribution to journalReview articlepeer-review

  3. Spectator no more, the role of the membrane in regulating ion channel function

    Pliotas, C. & Naismith, J. H., Aug 2017, In: Current Opinion in Structural Biology. 45, p. 59-66 8 p.

    Research output: Contribution to journalReview articlepeer-review

  4. Bacterial polysaccharide synthesis and export

    Woodward, L. S. & Naismith, J. H., Oct 2016, In: Current Opinion in Structural Biology. 40, p. 81-88 8 p.

    Research output: Contribution to journalArticlepeer-review

  5. Advances in understanding glycosyltransferases from a structural perspective

    Gloster, T. M., Oct 2014, In: Current Opinion in Structural Biology. 28, p. 131-141 11 p.

    Research output: Contribution to journalArticlepeer-review

ID: 19171471

Top