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Isolation of 5′-O-sulfamyladenosine and related 3′-O-β-glucosylated adenosines from the nucleocidin producer Streptomyces calvus

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Xuan Feng, Davide Bello, David O'Hagan

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Abstract

The isolation of three adenosine based metabolites 6–8 from Streptomyces calvus is reported. The metabolites are structurally related to the fluorine containing antibiotic nucleocidin 1 and two recently identified glycosylated fluoroadenosines 2 and 3, however in this case the three metabolites do not contain a fluorine, suggesting that the biosynthetic enzymes to the fluorometabolites also process their non-fluorinated counterparts.
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Original languageEnglish
Pages (from-to)5291-5294
Number of pages4
JournalRSC Advances
Volume11
Issue number10
Early online date28 Jan 2021
DOIs
Publication statusE-pub ahead of print - 28 Jan 2021

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